A small molecule that displays marked reactivity toward copper-versus zinc-amyloid-?? implicated in Alzheimer's disease

Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)-amyloid-?? (A??) over Zn(II)-A??.close3