20 research outputs found
Elevated levels of protein phosphatase 1 and phosphatase 2A may contribute to cardiac dysfunction in diabetes
AbstractAlthough protein phosphorylation and dephosphorylation are known to regulate the activities of different enzymes, sufficient information on the role of dephosphorylation in cardiac function is not available. Since protein phosphatases mediate dephosphorylation, it is possible that cardiac dysfunction induced by diabetes may be due to alterations in the activities of these enzymes. We therefore determined cardiac protein phosphatase activity as well as protein contents of phosphatase 1 and phosphatase 2A in diabetic animals. For this purpose, rats were made diabetic by administering a single intravenous injection of streptozotocin (65 mg/kg body weight) and hearts were examined after 1, 2, 3, 4 and 8 weeks. Some of the 4-week diabetic animals received subcutaneous injections of insulin (3 U/day) for a further period of 4 weeks. Cardiac dysfunction was evident after 2 weeks of inducing diabetes and deteriorated further with time. A significant increase in protein phosphatase activity appeared after 1 week and persisted until 8 weeks. Increased protein phosphatase activity in the diabetic heart was associated with a corresponding increase in the protein contents of both phosphatase 1 and phosphatase 2A. Insulin treatment partly prevented the changes observed in diabetic animals. The results suggest that increased protein phosphatase activities and subsequent enhanced protein dephosphorylation may play a role in diabetes-induced cardiac dysfunction
Trimetazidine influences phospholipid biosynthesis in cardiac cells
*INRA Unité de recherches nutrition lipidique BP 86510 21065 Dijon cedex (FRA) Diffusion du document : INRA Unité de recherches nutrition lipidique BP 86510 21065 Dijon cedex (FRA)National audienc
Is the cytoprotective effect of trimetazidine associated with lipid metabolism ?
6 graph.International audienc
Influence of the phospholipid n-6 : n-3 polyunsatured fatty acid ratio on the oxidative phosphorylation of isolated cardiac mitochondria
International audienc
Trimetazidine increases phospholipid turnover in ventricular myocyte
46 ref.International audienc
Trimetazidine influences phospholipid biosynthesis in cardiac cells
*INRA Unité de recherches nutrition lipidique BP 86510 21065 Dijon cedex (FRA) Diffusion du document : INRA Unité de recherches nutrition lipidique BP 86510 21065 Dijon cedex (FRA)National audienc
Aspects biochimiques de l'effet protecteur de la trimétazidine sur des cardiomyocytes de rat au cours de l'hypoxie suivie d'une réoxygénation
46 ref.National audienc