Экспозиционный динамический инженерносейсмометрический мониторинг здания Института геофизики УрО РАН с применением аппаратнопрограммного комплекса «Регистр-SD»

Seismometric monitoring of the building of the Institute of geophysics, located at Yekaterinburg was conducted in the period of 2017-2018. During the measurements, the hardware-software complex "Register-SD" with the electro-dynamic sensor SK-1P was used. The calculation of the period of natural oscillations of the object is given on the example of a vertical profile located in the south-eastern part of the building. The results of monitoring show that there are no failures in the studied section of the facility.В 2017-2018 гг. проведен сейсмометрический мониторинг здания Института геофизики с помощью аппаратно-программного комплекса «Регистр-SD» и электродинамического датчика СК-1П. Сделан расчет периода собственных колебаний объекта на примере вертикального профиля, расположенного в юговосточном крыле. Результаты мониторинга показывают отсутствие нарушений на изучаемом участке

Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits

Original article is published in: Frontiers in Bioscience, Landmark, 20, 892–901, January 1, 2015Glaucoma is the main cause of irreversible blindness worldwide. This disease is characterized by apoptosis of retinal ganglion cells (RGC) and visual field loss that seems to be related to elevated intraocular pressure (IOP). Several lines of evidences have implicated the crucial role of mitochondrial dysfunction in the pathogenesis of glaucoma. Increased mitochondrial oxidative stress in RGC may underlie or contribute to susceptibility of RGC to apoptosis. In our work we (i) designed a rabbit model of chronic, moderately elevated IOP for studying glaucoma and (ii) demonstrated efficacy of mitochondria-targeted antioxidant SkQ1 as a tool to reverse several traits of experimental glaucoma induced by a series of injections of hydroxypropylmethylcellulose (HPMC) to the anterior chamber of the rabbit eye. It is shown that 6 months instillations of drops of 0.2.5–5 µM solution of SkQ1 normalize IOP and eye hydrodynamics and abolish an increase in lens thickness that accompanies glaucoma.Original article is published in: Frontiers in Bioscience, Landmark, 20, 892–901, January 1, 2015Glaucoma is the main cause of irreversible blindness worldwide. This disease is characterized by apoptosis of retinal ganglion cells (RGC) and visual field loss that seems to be related to elevated intraocular pressure (IOP). Several lines of evidences have implicated the crucial role of mitochondrial dysfunction in the pathogenesis of glaucoma. Increased mitochondrial oxidative stress in RGC may underlie or contribute to susceptibility of RGC to apoptosis. In our work we (i) designed a rabbit model of chronic, moderately elevated IOP for studying glaucoma and (ii) demonstrated efficacy of mitochondria-targeted antioxidant SkQ1 as a tool to reverse several traits of experimental glaucoma induced by a series of injections of hydroxypropylmethylcellulose (HPMC) to the anterior chamber of the rabbit eye. It is shown that 6 months instillations of drops of 0.2.5–5 µM solution of SkQ1 normalize IOP and eye hydrodynamics and abolish an increase in lens thickness that accompanies glaucoma

Orbital glass and spin glass states of 3He-A in aerogel

Glass states of superfluid A-like phase of 3He in aerogel induced by random orientations of aerogel strands are investigated theoretically and experimentally. In anisotropic aerogel with stretching deformation two glass phases are observed. Both phases represent the anisotropic glass of the orbital ferromagnetic vector l -- the orbital glass (OG). The phases differ by the spin structure: the spin nematic vector d can be either in the ordered spin nematic (SN) state or in the disordered spin-glass (SG) state. The first phase (OG-SN) is formed under conventional cooling from normal 3He. The second phase (OG-SG) is metastable, being obtained by cooling through the superfluid transition temperature, when large enough resonant continuous radio-frequency excitation are applied. NMR signature of different phases allows us to measure the parameter of the global anisotropy of the orbital glass induced by deformation.Comment: 7 pages, 6 figures, Submitted to Pis'ma v ZhETF (JETP Letters

Особенности восприятия проблемы туберкулеза врачами первичного звена здравоохранения

The objective: to study the perception of the problem of tuberculosis in physicians working in primary medical care and enhance motivation to implement tuberculosis control activities.Subjects and methods. A questionnaire survey was conducted in 114 physicians from primary medical care before and after the lecture on phthisiology. A subjective assessment of the knowledge on tuberculosis (self-assessment) and results of an objective assessment were studied and compared.Results. 30% of physicians had the fear of getting infected and developing tuberculosis. The level of theoretical phthisiologic knowledge among physicians from primary medical care is insufficient; the self-assessment of this knowledge is overstated in 58.8%.Цель исследования: изучить особенности восприятия проблемы туберкулеза у врачей первичного звена здравоохранения и повысить эффективность мотивации по реализации противотуберкулезных мероприятий.Материалы и методы. Проведено анкетирование 114 врачей общей лечебной сети до и после образовательной лекции по фтизиатрии. Изучены субъективная оценка уровня знаний по вопросам фтизиатрии (самооценка) и результаты объективной оценки, проведено сравнение этих двух оценок.Результаты. Среди врачей страх заражения и заболевания туберкулезом имел место в 30%. Уровень теоретических знаний у врачей общей лечебной сети по разделу фтизиатрии недостаточен, у 58,8% самооценка этих знаний завышена

Phase diagram of superfluid 3He in "nematically ordered" aerogel

Results of experiments with liquid 3He immersed in a new type of aerogel are described. This aerogel consists of Al2O3 strands which are nearly parallel to each other, so we call it as a "nematically ordered" aerogel. At all used pressures a superfluid transition was observed and a superfluid phase diagram was measured. Possible structures of the observed superfluid phases are discussed.Comment: 6 pages, 8 figures. Submitted to Pis'ma v ZhETF (JETP Letters

Long-way-to-go from bowel urinary diversion to neobladder

The history of the development of urinary diversion methods dates over than 170 years. During this time, many methods of urinary diversion have been invented. Some never made it out of the research centres, while others were widely accepted by urologists and still in use today. In modern bladder cancer, doctors are not only concerned about saving human life in the immediate period, but also about how the patient will live after the cystectomy, which is a crippling surgery that affects both the quality of life and the patients’ social adaptation. The article presents the historical stages of urinary diversion techniques from the first attempts at derivation into the undisturbed colon to the creation of a low-pressure high-capacity neobladders

Митохондриально-направленный антиоксидант SkQ1 предотвращает глаукомные повреждения у кроликов

Original article is published in: Frontiers in Bioscience, Landmark, 20, 892–901, January 1, 2015Glaucoma is the main cause of irreversible blindness worldwide. This disease is characterized by apoptosis of retinal ganglion cells (RGC) and visual field loss that seems to be related to elevated intraocular pressure (IOP). Several lines of evidences have implicated the crucial role of mitochondrial dysfunction in the pathogenesis of glaucoma. Increased mitochondrial oxidative stress in RGC may underlie or contribute to susceptibility of RGC to apoptosis. In our work we (i) designed a rabbit model of chronic, moderately elevated IOP for studying glaucoma and (ii) demonstrated efficacy of mitochondria-targeted antioxidant SkQ1 as a tool to reverse several traits of experimental glaucoma induced by a series of injections of hydroxypropylmethylcellulose (HPMC) to the anterior chamber of the rabbit eye. It is shown that 6 months instillations of drops of 0.2.5–5 µM solution of SkQ1 normalize IOP and eye hydrodynamics and abolish an increase in lens thickness that accompanies glaucoma.Оригинальная статья опубликована: Frontiers in Bioscience, Landmark, 20, 892-901, January 1, 2015.Глаукома — основная причина необратимой слепоты в мире. Это заболевание характеризуется апоптозом ганглиозных клеток сетчатки (ГКС) и изменениями поля зрения, что, по-видимому, связано с повышенным внутриглазным давлением (ВГД). Есть основания полагать, что важную роль в патогенезе глаукомы играет митохондриальная дисфункция. Повышенный митохондриальный окислительный стресс в ГКС может лежать в основе или способствовать восприимчивости ГКС к апоптозу. В нашей работе мы (а) разработали модель хронического умеренно повышенного ВГД на кроликах для изучения глаукомы и (б) продемонстрировали эффективность митохондриально-направленного антиоксиданта SkQ1 в качестве инструмента для воздействия на некоторые проявления экспериментальной глаукомы, вызванной серией инъекций гидроксипропилметилцеллюлозы (ГПМЦ) в переднюю камеру глаза кролика. Показано, что инстилляции 0,2,5–5 мкМ раствора SkQ1 в течение 6-ти месяцев нормализуют ВГД и гидродинамику глаза, а также предотвращают увеличение толщины хрусталика, сопровождающее развитие экспериментальной глаукомы

Physics of Auroral Phenomena

Abstract. We have found that some largest deep faults of the lithosphere are manifested in the horizontal component of the Earth's magnetic field. We have compiled a databank of magnetic stations located outside the lithospheric deep faults using the geological data. Every two chosen magnetic stations must be located nearly on the same corrected geomagnetic latitude, but above different tectonic zones. One of them should be located above the lithospheric deep fault and the other -outside a zone of deep faults. The horizontal geomagnetic field components measured at these stations were compared with each other. It has been shown that horizontal geomagnetic field component at the magnetic station, located above the lithospheric deep fault is much larger, than the value measured at the station located outside the deep fault's zone. The analysis of the horizontal geomagnetic field components measured at a large number of the magnetic stations located over different tectonic regions has shown that the above mentioned characteristic is quite persistent

Glass protection via sol-gel coatings

An attempt was made to prepare and characterise sol-gel thin films in order to improve the scratch and abrasion resistance of glassware. The surface properties of the glass can be improved by depositing films showing a resistance to indentation higher than that of the substrate, good adhesion to it, and a regular surface morphology. Single oxide (ZrO2 or TiO2) and mixed oxide (ZrO2-B2O3 and TiO2-B2O3) films were deposited by dip coating from solution, followed by heat treatment. The surface mechanical properties of the prepared samples were characterised by scratch tests at constant and variable load, while the film morphology was characterised by contact profilometry, SEM and AFM. The best compromise between scratch hardness, critical load and roughness parameters was obtained using pure ZrO2 films about 1 micron thick