Use of knee height for the estimation of stature in elderly Turkish people and their relationship with cardiometabolic risk factors

The determination of the approximately truest value in height measurement is important in many fields, but it is difficult to perform true measurements, especially in the elderly individuals. We planned to investigate the following items in geriatric Turkish population: to calculate the decrease in height with advancing age by using the standing height measurement and estimated height derived from the knee height; to evaluate the significance of difference between the two measurement methods in the calculation of body mass index (BMI) and waist/height ratio (WHtR); to determine the cut-off value of WHtR according to estimated height in elderly individuals. We studied 551 cases aged between 19 and 97 years. Knee height was measured using a sliding caliper in a sitting position. Linear regression analysis was carried out to derive predictive equations for the estimation of stature with adults ( 60 years (mean: 69.51 +/- 7.12). Estimated BMI (EBMI) measurements in the females and males > 60 years were in average 1.23 kg/m(2) and 0.92 kg/m(2) higher than their real BMIs, respectively. EBMI measurements in the females 60 years, as compared to our estimated WHtR (EWHtR) measurements (p 60 years in our study, respectively. WHtR seemed to be a better anthropometric index that could predict most cardiometabolic risk factors in our study. EWHtR emerged to be a better cardiometabolic risk index especially in the elderly group. Crown Copyright (C) 2010 Published by Elsevier Ireland Ltd. All rights reserved

Parenthood experiences of LGBT plus individuals: a systematic review

OBJECTIVE: This systematic review aims to analyze the parenthood experiences of LGBT+ individuals. METHODS: The review was carried out between February and June 2020 and used key words about LGBT+ and/or parenthood, including, ???lesbian and mother,??? ???lesbian and parenthood,??? ???gay and father,??? ???gay and parenthood,??? and ???trans and parenthood,??? which were published in databases, such as PubMed, Google Academic, Wiley Online Library, and ScienceDirect. RESULTS: We reviewed 19 research articles, and the majority of these articles suggested that LGBT+s faced negative reactions and discrimination when they decided to become parents. Once they became parents, the relationship of most of the LGBT+ individuals with their partners and the surrounding social environment improved and social support for and self-esteem of the LGBT+ individuals increased. CONCLUSIONS: Compared to the heterosexual parents, LGBT+ individuals faced with various problems in their social, family, and professional lives during parenthood. Therefore, they need more family, legal, and social support

Effects of different statins, ezetimibe/simvastatin combination On hsCRP levels in unstable angina pectoris and non-ST elevation myocardial infarction patients: a randomized trial

WOS: 000298576700009PubMed ID: 22088858Objective: The aim of our study was to evaluate the effects of two different statins and a statin/ezetimibe combination on high sensitive C-reactive protein (hsCRP) values, which were given at high doses in the early period of acute coronary syndromes. Methods: A total of 150 patients with non-ST elevation myocardial infarction and unstable angina pectoris were enrolled to our prospective, randomized, single-blind study. Patients were divided into three groups by block randomization method. One group received 20mg/day atorvastatin, one group received 10 mg/day rosuvastatin and the other group received 10 mg/day ezetimibe/simvastatin combination therapy, which was initiated within the first 24 hours of admission. Follow-up duration was 2 months. Biochemical investigations and hsCRP levels (by nephelometric method) were performed with 138 patients evaluated at baseline, 10(th) and 60(th) days of therapy. Decreases of hsCRP levels were analyzed with one-way MANOVA and repeated measures of ANOVA methods. Post-hoc Tukey HSD test was performed for finding the different group, when the difference was detected between the groups. Results: Tenth day hsCRP levels in ezetimibe/simvastatin group was significantly lower than the other groups (p<0.001). Further, after 60 days of follow-up a significant reduction was seen in hsCRP levels in ezetimib/simvastatin group (in ezetimibe/simvastatin group the mean hsCRP was reduced from 38.4 +/- 15.0 mg/L to 2.4 +/- 1.3 mg/L, in atorvastatin group the mean hsCRP was reduced from 27.3 +/- 11.7 mg/L to 4.1 +/- 2.4 mg/L and in rosuvastatin group the mean hsCRP was reduced from 22.0 +/- 6.9 mg/L to 3.6 +/- 1.7 mg/L (F (1.1, 148.2) = 746.9, p<0.01 and the difference between drugs; F (2.2, 148.2) = 32.1, p<0.01). No side effects related to drugs were seen during follow-up in all three treatment groups. Conclusion: This study showed that ezetimibe/simvastatin 10 mg/day combination treatment was superior to atorvastatin 20 mg/day and rosuvastatin 10 mg/day treatment in reducing the inflammatory markers when high dose statins was started in the early period of unstable angina and non ST elevation myocardial infarction. (Anadolu Kardiyol Derg 2011; 11: 703-10

From Diagnosis to Recovery: Addressing Rare Malaria with Travel History Using Standard and Apheresis Therapies

This case report details the diagnosis, treatment, and management of a rare case of severe malaria in a 57-year-old male with a significant travel history, having returned from Sudan where he worked as a textile master for three years. Despite initial improvement after standard malaria treatment 1.5 years prior in Sudan, the patient presented with high fever, chills, shivering, weakness, and loss of appetite in October 2023. Laboratory findings indicated an infection, and an abdominal ultrasound revealed hepatic steatosis and splenomegaly. A peripheral smear confirmed the presence of Plasmodium vivax. Given the severity of the patient's condition, characterized by hypotension and the risk of complications due to his background of diabetes, hypertension, and cardiovascular disease, he was treated with a combination of standard antimalarial therapy (artemether, lumefantrine, and primaquine) and erythrocyte exchange apheresis. This multidisciplinary approach led to significant improvement in his health. This case underscores the importance of considering travel history in the differential diagnosis and highlights the efficacy of combining erythrocyte exchange apheresis with standard antimalarial therapy in managing severe cases of malaria, which is particularly rare in non-endemic regions

Comparison of Esmolol to Nitroglycerine in Controlling Hypotension during Nasal Surgery

Objective: The aim of this study was to compare esmolol to nitroglycerine in terms of effectiveness in controlling hypotension during nasal surgery. Materials and Methods: After approval by our institutional Ethics Committee, 40 patients were recruited and randomized into two drug groups: esmolol (Group E) and nitroglycerine (Group N). In group E, a bolus dose of 500 μg/kg esmolol was administered over 30 sec followed by continuous administration at a dose of 25-300 μg/kg/min to maintain systolic arterial pressure at 80 mmHg. In group N, nitroglycerine was administered at a dose of 0.5-2 μg/kg/min. Results: During the hypotensive period, systolic arterial pressure, diastolic arterial pressure, mean arterial pressure, and heart rate were decreased 24%, 33%, 27% and 35%, respectively, in group E (p<0.001, p<0.001, p<0.001, p<0.001) and were decreased 30%, 33%, 34% and 23%, respectively, in group N (p<0.001, p<0.001, p<0.001, p<0.001). The decrease in heart rate was higher in group E during the hypotensive period (p=0.048). During the recovery period, diastolic arterial pressure and heart rate were decreased 9% and 18%, respectively, in group E (p=0.044, p<0.001). Systolic arterial pressure, diastolic arterial pressure, and mean arterial pressure were decreased 7%, 3% and 7%, respectively, in group N (p=0.049, p=0.451, p=0.045). Conclusion: Esmolol provides hemodynamic stability and good surgical field visibility and should be considered as an alternative to nitroglycerine

Kadınlarda Küçük Hücreli Dışı Akciğer Kanseri: Farklı Bir Antite mi?

Non-Small Cell Lung Cancer in Women: A Distinct Entity?Kadınlarda Küçük Hücreli Dışı Akciğer Kanseri: Farklı Bir Antite mi?Umut Kefeli1, Bala Basak Oven Ustaalioglu2, Burcak Yilmaz2, Dincer Aydin3, Nur Sener3, Mehmet Aliustaoglu3Mahmut GumusAmaç: Akciğer kanseri her iki cinsiyette de kanser ile ilişkili önde gelen ölümnedenlerinden biridir ve tüm dünyada giderek artmaktadır. Birçok çalışmadainsidans ve mortalitedeki bu artış cinsiyet, tümör tipi ve hastaların klinikkarakteristikleri ile ilişkili bulunmuştur. Bu çalışmanın amacı kadın küçükhücreli dışı akciğer kanserli (KHDAK) hastalarda klinik özellik farklılıklarını veprognostik faktörleri araştırmaktır.Gereç ve Yöntem: 2005-2012 yılları arasında 893 KHDAK’lı hastanın verilerigeriye yönelik incelendi. Hastaların 773’ü erkek (%86.5) ve 120’si (%13.5)kadındı. Hastaların demografik verileri, histolojik tipleri, klinik evreleri,semptomları ve tedavi modaliteleri incelendi. Sağkalım Kaplan-Meier metoduve prognostik faktörler log-rank ve Cox regresyon testleri ile analiz edildi.Bulgular: Kadın hastaların medyan yaşı 60.6 idi. Erkek hastalarda sigaraöyküsü olanların oranı % 89.6 iken, kadın hastalarda bu oran % 44.9 olarakbulundu. Kadınlarda en sık tümör tipi adenokarsinom (%32.7),erkeklerdeskuamöz hücreli karsinomdu (%34.0). Kadın hastaların medyan genelsağkalımı 13.7 ay, erkek hastaların 10.9 ay olarak saptandı (p&gt;0.05). Tekdeğişkenli analizlerde kadın hastalarda yaş, kilo kaybı, kombinasyon tedavisive performans statüsü sağkalımı artıran faktörlerdi. Çok değişkenlianalizlerde kadın hastalarda sağkalım ile ilşkili tek faktör iyi performansstatüsüydü.Sonuç: Kadınlarda KHDAK erkeklere göre farklıdır. Kadınlarda adenokarsinomdaha sıktır ve KHDAK daha iyi prognozludur. Kadın KHDAK’nin daha detaylıanlaşılması yeni tedavi ve prevensiyon stratejelerinin geliştirilmesine olanaksağlayacaktır.Anahtar Sözcükler: Cinsiyet, akciğer kanseri, kadınABSTRACTAim: Lung cancer is one oKey Words: Sex, lung canNon-Small Cell Lung Cancer in Women: A Distinct Entity?Kadınlarda Küçük Hücreli Dışı Akciğer Kanseri: Farklı Bir Antite mi?Umut Kefeli1, Bala Basak Oven Ustaalioglu2, Burcak Yilmaz2, Dincer Aydin3, Nur Sener3, Mehmet Aliustaoglu3Mahmut GumusABSTRACTAim: Lung cancer is one of the major causes of cancer-related deaths in bothsexes and increasing worldwide. In many studies this increase in incidenceand mortality was related to the sex, tumor type and clinical characteristicsof the patients. The aim of this study was to evaluate the differences inclinical features and the prognostic factors in our female patients withNSCLC.Methods: We retrospectively analyzed the records of our 893 patients withnon-small cell lung cancer (NSCLC) from 2005 to 2012. Of these, 773 weremale (86.5%) and 120 were female (13.5%) patients. The data includeddemographic information, histologic classification, clinical staging, presentingsymptoms and treatment modalities. Survival was estimated by usingKaplan–Meier method and prognostic factors were evaluated with log-rankand Cox regression tests.Results: The median age of the female patients was 60.6. The percent of themale and female patients that had a smoking history was 89.6% and 44.9%,respectively. Most common tumor type in female patients wasadenocarcinoma (32.7%) and in male patients was squamos cell carcinoma(34.0%). The median survival time for female patients was 13.7 months andfor the male patients it was 10.9 months (p&gt;0.05). In univariate analysis, age,weight loss, combination therapy and PS correlated with a better OS forfemale patients. In multivariate analysis, only good PS showed consistencywith survival for women.Conclusion: NSCLC in women is different in women as compared with men.Women are more likely to develop adenocarcinoma of the lung and havemore favorable prognosis. A more through understanding of the NSCLC inwomen may lead to new treatment and prevention strategies.Key Words: Sex, lung cancer, women</div