23 research outputs found
Noise trauma and systemic application of the selective glucocorticoid receptor modulator compound A
Effects of hypothermically reduced plantar skin inputs on anticipatory and compensatory balance responses
Specific Blockage of Caspase-1 Activation by Purple Bamboo-Salt Prevents Apoptosis of Auditory Cell Line, HEI-OC1
Sudden sensorineural hearing loss: Is there a connection with inner ear electrolytic disorders? A literature review
Sudden sensorineural hearing loss: Is there a connection with inner ear electrolytic disorders? A literature review
Electrolytic disorders of the inner ear represent a model that could be implicated in partially explaining the pathogenesis of sudden sensorineural hearing loss (SSNHL). Different types of electrolytes and different inner-ear loci are involved in cochlear homeostasis physiologically, to ensure the maintenance of an ion-balanced cochlear environment allowing a normal hair cell function. It has been hypothesized that a sudden loss of endocochlear potential, due to a rapid disruption of the inner ear fluid osmolality, could be responsible for a deterioration of the hearing function caused by damaged hair cells. The aim of this paper was to review the current literature and identify sources which might validate/fortify the hypothesis that inner ear electrolytic disorders have a role in the etiopathogenesis of SSNHL. The data in the literature underline the importance of ionic homeostasis in the inner ear, but they do not support a direct link between SSNHL and electrolyte disorders/imbalances. There is marginal evidence from otoacoustic emissions research that an indirect link might be present