Lichen planus pigmentosus and frontal fibrosing alopecia: The link explored

There has been a recent rush of data regarding the combined presentation of lichen planus pigmentosus and frontal fibrosing alopecia in premenoposal women of dark skin. This review article addresses the relationship between the two

Clindamycin Induced Dysphagia – A Rare Concurrence

Although dysphagia is a mechanical impedance in phase specific mechanism, drug induced dysphagia is an adverse event often caused due to esophagitis. Clindamycin is well known to cause esophagitis; itself causing dysphagia is not reported in literature. Herein, we report one such case recently seen by us who was diagnosed with Clindamycin induced dysphagia post debridement surgery for acute necrotizing fasciitis

Autologous serum and plasma skin tests in chronic spontaneous urticaria: A reappraisal

Aim: The objective of this study was to assess autologous serum skin test (ASST) vs autologous plasma skin test (APST) response in chronic spontaneous urticaria (CSU) patients and study the significance of intensity of positive responses in relation to clinicoepidemiological parameters. Materials and Methods: One hundred CSU patients and 100 age and sex-matched controls were recruited. The demographic and clinical features were recorded in all patients and routine investigations were performed. ASST and APST tests were performed as per the standard guidelines. Results: The mean duration of illness was 4.85 ± 5.07 years, 90% patients were APST (+), 68% ASST (+), and 22 patients were only APST (+). Positive predictive value (PPV) of ASST and APST was 90.7% and 95.7%, respectively. A significant inverse association was seen between thyroid status and serum IgE levels with APST and ASST positivity. Conclusion: APST appears to have better PPV and high intensity of positive response on autologous tests, and correlates with ANA positivity and angioedema

Clindamycin Induced Dysphagia – A Rare Concurrence

Abstract: Although dysphagia is a mechanical impedance in phase specific mechanism, drug induced dysphagia is an adverse event often caused due to esophagitis. Clindamycin is well known to cause esophagitis; itself causing dysphagia is not reported in literature. Herein, we report one such case recently seen by us who was diagnosed with Clindamycin induced dysphagia post debridement surgery for acute necrotizing fasciitis

Coexistence of linear and inversus variants of lichen planus pigmentosus: A rare occurrence

Lichen planus pigmentosus (LPP) is a rare disorder affecting primarily the people with ethnic skin. It results in hyperpigmentation of sun-exposed sites along with the involvement of flexures. In accordance with clinical patterns, different variants such as diffuse, blotchy, reticulate, and perifollicular have been described. Rare variants such as flexural (inversus), mucosal, linear, and zosteriform have been reported scarcely. Inversus LPP refers to the involvement of major flexures such as inframammary area, axillae, and groins in the absence of involvement of photo-exposed sites. We present an unusual case presenting with coexisting linear and inversus variants of LPP

Original Article - Study of desmoglein 1 and 3 antibody levels in relation to disease severity in Indian patients with pemphigus

Objectives : To conduct a cross-sectional study to compare Dsg1 and Dsg3 antibody levels independently with severity of disease activity in pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Methods : Blood samples from 44 patients with pemphigus (PV-38, PF-6) were analyzed using ELISA. The severity of skin and mucosal disease was graded using a score from 0 to 3. Results: A statistically significant correlation between increase in Dsg 3 antibody titres with severity of oral involvement and Dsg 1 titres with severity of skin involvement was found in both PV and PF patients ( p < 0.01). However, we were unable to demonstrate a relationship between increased titres of Dsg1 and Dsg 3 antibodies with oral and skin involvement respectively. Conclusion : This study suggests that the severity of skin and oral disease in pemphigus is determined by the quantities of Dsg1 and Dsg3 antibodies respectively