DATABASE OF RECIPROCATING INTERNAL COMBUSTION ENGINES SELECTED MANUFACTURERS

During research works concerning piston internal-combustion engines specifications of these objects are often needed. This data is usually dispersed and reaching to some is hampered or impossible. Therefore, an electronic database was drawn up about the most important ship producer’s piston internal-combustion engines for needs of exploitation investigations in the destination of gathering the necessary information. This paper presents a database of global marine diesel engines. For example, engines of the following companies were described: Akasaka Diesel, CAT, Cummins, Fiat, Hyundai, MTU, Niigata Power Systems, Pielstick, Scania, Volvo Penta etc. Information was obtained from various sources, so as websites of producers, advertising catalogues, or books and magazines about subject matter associated with marine diesel engines. This information was collected and written with the help of the program Microsoft Office. Gathered data was divided in engines of the main drive and emergency, containing details about producers, types and parameters of 2-stroke engines and four-stroke. The base enables supplementing and the alteration of entered data. Produced engines are usually operated by several dozen years after producing on swimming objects. Produced internal combustion engines are usually operated by several dozen years after producing on floating objects, and producers are merging or are stopping existing

Database of reciprocating internal combustion engines selected manufacturers

During research works concerning piston internal-combustion engines specifications of these objects are often needed. This data is usually dispersed and reaching to some is hampered or impossible. Therefore, an electronic database was drawn up about the most important ship producer’s piston internal-combustion engines for needs of exploitation investigations in the destination of gathering the necessary information. This paper presents a database of global marine diesel engines. For example, engines of the following companies were described: Akasaka Diesel, CAT, Cummins, Fiat, Hyundai, MTU, Niigata Power Systems, Pielstick, Scania, Volvo Penta etc. Information was obtained from various sources, so as websites of producers, advertising catalogues, or books and magazines about subject matter associated with marine diesel engines. This information was collected and written with the help of the program Microsoft Office. Gathered data was divided in engines of the main drive and emergency, containing details about producers, types and parameters of 2-stroke engines and four-stroke. The base enables supplementing and the alteration of entered data. Produced engines are usually operated by several dozen years after producing on swimming objects. Produced internal combustion engines are usually operated by several dozen years after producing on floating objects, and producers are merging or are stopping existing

A database of piston marine diesel engines produced in H. Cegielski Poznań S. A. and ZUT Zgoda

W czasie prac badawczych dotyczących tłokowych silników spalinowych często potrzebne są dane techniczne tych obiektów. Dane te są zwykle rozproszone i dotarcie do niektórych jest utrudnione lub niemożliwe. Opracowano, zatem elektroniczną bazę danych o najważniejszych producentach okrętowych tłokowych silnikach spalinowych dla potrzeb badań eksploatacyjnych w celu zgromadzenia niezbędnych informacji. W tej pracy przedstawiono bazę danych głównych polskich producentów okrętowych tłokowych silników spalinowych. Informacje zostały pozyskane z różnych źródeł, takich jak: strony internetowe producentów, katalogi reklamowe, książki i czasopisma o tematyce związanej z okrętowymi silnikami spalinowymi. Informacje te zostały zebrane i zapisane przy pomocy programu Microsoft Office. Zgromadzone dane podzielono na silniki napędu głównego i pomocnicze, zawierający dane o producentach, typach i parametrach silników dwusuwowych i czterosuwowych. Baza umożliwia uzupełnianie i modyfikację wprowadzonych danych. Wyprodukowane silniki eksploatowane są zwykle przez kilkadziesiąt lat po wytworzeniu na obiektach pływających.During research works concerning piston internal-combustion engines specifications of these objects are often needed. This data is usually dispersed and reaching to some is hampered or impossible. And so an electronic database was drawn up about the most important ship's producer’s piston internal-combustion engines for needs of exploitation investigations in the destination of gathering the necessary information. At this work a database of main Polish producers of marine diesel engines was presented. Information was obtained from various sources, so as: websites of producers, advertising catalogues, or books and magazines about subject matter associated with marine diesel engines. This information was collected and written with the help of the program Microsoft Office. Gathered data was divided in engines of the main drive and emergency, containing details about producers, types and parameters of 2-stroke engines and four-stroke. The base enables supplementing and the alteration of entered data. Produced engines are usually operated by several dozen years after producing on swimming objects

Salt stabilization of a 5S RNA-protein complex from an extreme halophile, Halobacterium cutirubrum: FEBS Lett.

NRC publication: Ye

Clinical-pathological features and treatment modalities associated with recurrence in DCIS and micro-invasive carcinoma: Who to treat more and who to treat less

The primary aim in the management of DCIS is the prevention of recurrence and contralateral tumor. Risk factors for DCIS recurrence and appropriate treatments are still widely debated. Adjuvant therapies after surgical resection reduce recurrences and contralateral disease, but these treatments have significant financial costs, side effects and there is a group of low-risk patients who would not gain additional benefit. The aim of our analysis was to identify clinical-pathological features and treatment modalities associated with recurrence in DCIS and microinvasive carcinoma. In the Thomas Jefferson University Cancer Registry of Philadelphia, we identified 865 patients with DCIS or micro-invasive carcinoma treated between 2003 and 2013. Associations between recurrence and demographic factors (age at diagnosis, ethnicity), biological features (ER, PR and HER2) and treatment modalities (surgery, radiotherapy and endocrine treatment) were assessed. Our single institution register-based study showed that distribution of age at diagnosis and biological features did not significantly differ among ethnic groups. Younger women and micro-invasive carcinoma patients were more likely to undergo mastectomy, while African Americans were more likely to take endocrine therapy and undergo radiotherapy. In our sample only ER/PR negative DCIS were associated with significantly higher recurrence rate. Moreover, we reported a high rate of HER2 positive recurrences, suggesting that expression of this oncogene may represent a potential biomarker for DCIS at high risk of recurrence. To better define the molecular profile of the subgroup at worse prognosis might help to identify biomarkers predictive of recurrence or second tumors, identifying patients candidates for more appropriate treatments

Circadian gene expression and clinicopathologic correlates in pancreatic cancer.

INTRODUCTION: The circadian rhythm is responsible for physiologic homeostasis, behavior, and components of multiple metabolic processes. Disruption of the circadian rhythm is associated with cancer development, and several circadian clock genes have been implicated in loss of cell cycle control, impaired DNA damage repair, and subsequent tumor formation. Here, we investigated the expression profiles of several circadian clock genes in pancreatic ductal adenocarcinoma (PDA). METHODS: Quantitative real-time polymerase chain reaction was used to examine the circadian clock genes (brain-muscle-like (Bmal)-ARNTL, circadian locomotor output cycles kaput (Clock), cryptochrome 1 (Cry1), cryptochrome 2 (Cry2), casein kinase 1ε (CK1ε), period 1 (Per1), period 2 (Per2), period 3 (Per3), timeless (Tim), and timeless-interacting protein (Tipin)) in PDA, as well as matching adjacent and benign tissue. Logistic regression models with robust variance were used to analyze the gene expression levels, and Kaplan-Meier survival curves were generated based on gene expression. RESULTS: In the tumor tissue of PDA patients, compared to their matched adjacent tissue, expression levels of all circadian genes were lower, with statistical significance for Per1, Per2, Per3, Cry1, Cry2, Tipin, Tim, CK1ε, Bmal-ARNTL, and Clock (p \u3c 0.025). PDA tumors also expressed significantly lower levels of the circadian genes when compared to benign lesions for Per1, Per2, Per3, Cry2, Tipin, and CK1ε. A significant association between low levels of expression in the tumors and reduced survival was found with Per1, Per2, Per3, Cry2, Tipin, CK1ε, Clock, and Bmal-ARNTL. CONCLUSIONS: Our results reveal for the first time a dysregulated transcription of several circadian genes in PDA. Elevation of the gene levels in the benign and matched adjacent tissues may be indicative of their role during the process of tumorigenesis. The potential of using circadian genes as predictive markers of the outcomes and survival and distinguishing PDA from benign pancreas must be studied in larger populations to validate and demonstrate their eventual clinical utility

RAN GTPase and Osteopontin in Pancreatic Cancer.

INTRODUCTION: Pancreatic ductal adenocarcinoma (PDA) has the worst prognosis among cancers, mainly due to the high incidence of early metastases. RAN small GTPase (RAN) is a protein that plays physiological roles in the regulation of nuclear transport and microtubule spindle assembly. RAN was recently shown to mediate the invasive functions of the prometastatic protein osteopontin (OPN) in breast cancer cells. We and others have shown previously that high levels of OPN are present in PDA. In this study, we analyzed the expression and correlation of RAN with OPN in human pancreatic lesions, and explored their regulation in PDA cell lines. METHODS: Real time PCR was used to analyze RAN and OPN mRNA levels in PDA, adjacent non-malignant, and benign pancreatic tissues. Expression levels were correlated with survival and different clinicopathological parameters using different statistical methods. Transient transfection studies using OPN and RAN plasmids, and knockdown experiments using siRNA were used to examine their mutual regulation. RESULTS: OPN and RAN levels highly correlated with each other (p CONCLUSIONS: The high levels of RAN in PDA and its correlation with OPN and with perineural invasion suggest that RAN may contribute to PDA metastasis and progression through the induction of OPN. RAN\u27s role in the regulation of OPN in PDA is unique and could provide potential novel therapeutic strategies to combat PDA aggressiveness

Suture Compared With Staple Skin Closure After Cesarean Delivery A Randomized Controlled Trial

OBJECTIVE: To compare the incidence of wound complications between suture and staple skin closure after cesarean delivery. METHODS: This prospective, randomized clinical trial conducted at three hospitals in the United States between 2010 and 2012 included women undergoing cesarean delivery at 23 weeks of gestation or greater through a low-transverse skin incision. Women were randomized to closure of the skin incision with suture or staples after stratifying by body mass index and primary compared with repeat cesarean delivery. The primary outcome was incidence of wound complications, predefined as a composite of infection, hematoma, seroma, separation of 1 cm or longer, or readmission for wound complications. Analysis was according to the intention-to-treat principle; results were stratified by randomization group and adjusted for hospital by including it as a covariate. RESULTS: A total of 746 women were randomized, 370 to suture and 376 to staple closure. The median gestational age was 39 weeks. Fifty-eight women (7.8%) had wound complications-4.9% in the suture group and 10.6% in the staple group (adjusted odds ratio [OR] 0.43, 95% confidence interval [CI] 0.23-0.78); this was largely the result of the decreased incidence of wound separation in the respective groups (1.6% compared with 7.4%; adjusted OR 0.20, 95% CI 0.07-0.51). CONCLUSIONS: Suture closure of the skin incision at cesarean delivery is associated with a 57% decrease in wound complications compared with staple closure