1 research outputs found
Evaluation of anti-ulcer activity of Samanea saman (Jacq) merr bark on ethanol and stress induced gastric lesions in albino rats
Objective : To evaluate the antiulcer activity of Samanea saman
(Jacq) Merr bark on ethanol and stress induced gastric lesions in
albino rats. Materials and Methods : Gastric lesions were induced in
rats by oral administration of absolute ethanol (5 ml/kg) and stress
induced by water immersion. The antiulcer activity of methanolic
extract of Samanea saman (Jacq) Merr bark (100 mg/kg, 200 mg/kg, 400
mg/kg) was compared with standard drugs. The parameters studied were
ulcer index, gastric juice volume, pH, free acidity and total acidity.
Result : Samanea saman (Jacq) Merr showed a dose dependent curative
ratio compared to ulcer control groups. The extract at 400 mg/kg showed
significant anti ulcer activity which is almost equal to that of the
standard drug in both models. The volume of acid secretion, total and
free acidity was decreased and pH of the gastric juice was increased
compared to ulcer control group. Conclusions : The present study
indicates that Samanea saman (Jacq) Merr bark extracts have potential
anti ulcer activity