Issues in the study of utero-placental blood flow in severe gestosis

The complications of pregnancy, gestosis particularly, are still important aspects on the modern stage of development of obstetrics, as it influences on development of maternal and perinatal morbidity and mortality. One hundred and twenty-five patients with severe gestosis were studied. The conditions of myometrium, endometrium, placenta, umbilical chord as well as erythrocytes of maternal blood were explored with help of atomic power microscopy, light microscopy as well as electron microscop

The Maupertuis principle and canonical transformations of the extended phase space

We discuss some special classes of canonical transformations of the extended phase space, which relate integrable systems with a common Lagrangian submanifold. Various parametric forms of trajectories are associated with different integrals of motion, Lax equations, separated variables and action-angles variables. In this review we will discuss namely these induced transformations instead of the various parametric form of the geometric objects

Polymeric Coatings Composition Based on Modified Oligopiperylene Styrene Binders with Galvanic Sludge as a Filler

Abstract The possibility of development of new coating materials based on oligopiperylene styrene modified with alkoxysilane and galvanic sludge as a pigment-filler is presented in this article. The nanostructure of the coating surface and the influence of the composition and nature of the components of paint and varnish materials on its property are studied. These materials are intended for protection buildings from the effects of adverse factors

EVALUATION OF THE PROTECTIVE EFFECTIVENESS OF AQUEOUS PLANT EXTRACTS IN THE COMPOSITION OF CORROSION INHIBITOR EXTRACT

Актуальним науково-технiчним завданням є вивченнякорозiйних процесiв i пошук дешевих та ефективних методiв захисту.Унаслiдок корозiйного руйнування втрачається близько 10% рiчноговиробництва металу. Тому антикорозiйним заходам придiляється значнаувага. Iнгiбiтори iржi є ефективним способом ї ї видалення та захистувiд корозiї. Останнiм часом пiдвищений iнтерес викликають так званi«зеленi iнгiбiтори». Багато рослин є джерелом таких iнгiбiторiв, комплексусполук алкалоїдiв, полiсахаридiв, бiлкiв, слизових i дубильних речовин.Усi вони, хоча i в рiзному ступенi, здатнi адсорбуватися на металевiйповерхнi та закрiплюватися на нiй. Проведенi дослiдження демонструютьможливостi захисту металiв вiд корозiї за допомогою екстрактiв рослин:томата їстiвного Solanum lycopersicum, чистотiлу Chelidonium majus L.,Althaea officinalis L., деревiю Achillea millefolium L.An urgent scientific and technical task is the study of corrosionprocesses and finding cheap and effective methods of protection. As a result ofcorrosion destruction, about 10% of annual metal production is lost. Therefore,considerable attention is paid to anti-corrosion measures. Rust inhibitors arean effective way to remove rust and protect against corrosion. Recently, theso-called “green inhibitors” have aroused increased interest. Many plants are asource of such inhibitors, a complex of compounds — alkaloids, polysaccharides,proteins, mucous and tannins. All of them, although to varying degrees,have the ability to be adsorbed on a metal surface and fixed on it. Weconducted research on the possibility of protecting metals from corrosionwith extracts: Tomato edible Lycopersicum, Celandine Chelidonium majus L,Althaea Althaea officinalis L., Yarrow Achillea millefolium

LYMPHOCYTE PHENOTYPE IN PATIENTS WITH SKIN MELANOMA AFTER IMMUNOTHERAPY OF ACTIVATED LYMPHOCYTES

The major medical problem in the treatment of skin melanoma is improvement methods of treatment, increasing their effectiveness and safety. In this study, adoptive immunotherapy, using lymphocytes activated in vitro, was performed in 15 patients with metastatic melanoma. Evaluated the phenotype of peripheral blood lymphocytes and activation markers (HLA-DR, CD25, CD314, CD38, CD69) before and 3-4 weeks after immunotherapy. It is shown that for these patients is characterized by increasing the number of CD25+ and Treg lymphocytes in the bloodstream, which has not changed after immunotherapy. Adoptive immunotherapy in combination with chemotherapy resulted in a decrease of absolute number of lymphocyte, B- and T-lymphocytes, T helper cells, NKT-cells, CD314+ lymphocytes, CD38+ lymphocytes and immature T-lymphocytes (CD3+CD38+) (р < 0,05). However, there was a positive dynamic to increase the percentage of NK-cells to 32% and CD69+NK-cells to 21% and significant increase in expression of HLA-DR on all lymphocytes (p < 0.05). Adoptive immunotherapy characterized by the absence of side effects and can be recommended as accompanying to basic radiation and chemotherapy

The use of atomic force microscopy in comprehensive assessment of the "mother-placenta-fetus" system in obstetric and endocrine pathology during pregnancy

Our study summarizes the possibilities of using atomic force microscopy for detection of various circulatory disorders and vascular changes at the microscopic level in the uterus (endometrium and myometrium), placenta, and umbilical cord in the main variants of obstetric and endocrine patholo

New approaches in assessing the clinical and pathomorphological aspects of obstetric pathology in the structure of the mother-placenta-fetus using atomic force research

The aim of the research is study of histological features of the placenta’s and uterus’ structure, erythrocytes in the mother-placenta-fetus system during pregnancy, occurring against the background of thyroid diseases, diabetes (type I and gestational), moderate and severe preeclampsi

Morphological features of autoimmune gastritis

Aim of investigation. To estimate presence of classical morphological signs of autoimmune gastritis (AIH) in patients with high titer of antiparietal cells antibodies.Material and methods. Overall 15 patients (3 men and 12 women, 28 to 72 years old) have been included in original study. Clinical symptoms in the study group varied and included both severe В12-deficient anemia and normal levels of pepsinogen I, gastrin-17 and cyanocobalamine. In 4 patients Helicobacter pylori infection has been detected. According to guidelines of the Russian Society of Pathologists in all cases multiple biopsies have been taken at esophagogastroduodenoscopy. Biopsy specimens were processed by the standard technique, sections were stained by hematoxyline and eosine.Results. Classical signs of AIH i.e. atrophy of mucosa of body of the stomach and intestinal metaplasia were not revealed. The signs of feeble inflammation in body of the stomach were found in 6 patients. In 4 cases biopsy specimens had no inflammatory or atrophic changes. Pseudo-hypertrophy of parietal cells was the unique morphological feature found out in these cases. At all patients involvement of antral region of the stomach was marked. Atrophic gastritis with intestinal metaplasia was diagnosed in 4 patients. In 3 cases non-metaplastic variant of patchy atrophic gastritis was present, the rest revealed superficial gastritis with signs of activity in 4 cases. No Н. рylori was found out morphologically.Conclusion. In our investigation in patients with AIG no metaplastic atrophic lesions was found in body of the stomach, while metaplastic atrophy had patchy pattern. The pseudo-hypertrophy of parietal cells as well as dilation of main glands lumen can be the earliest and unique sign found in biopsy specimens. Involvement of antral region was revealed in all patients, in 4 cases it has been related to presence of H. pylori infection at the moment of investigation. Thus, the diagnosis of AIG was based mainly on elevated level antiparietal cells antibodies at blood serum test

Intraoperative Intraluminal Endoscopy in the Surgical Treatment of Patients with Esophageal Diverticula of Various Localization

Aim. To improve the results of surgical treatment of patients with esophageal diverticulum of various localization using intraoperative intraluminal endoscopy. Materials and Methods: The Department of Surgery of the Esophagus and Stomach, the Petrovsky National Research Centre of Surgery, has accumulated a large experience in treating diverticulosis patients. Thus, during the 2010–2018 period, 74 patients with esophageal diverticula of various localization were operated. Out of them, 56 (75.7 %), 10 (13.5 %) and 8 (10.8 %) patients underwent surgical treatment with respect to faringo-esophageal, bifurcation and epiphrenic diverticula, respectively. The patients were divided into two groups: 31 people (41.9 %) in the main group underwent diverticulectomy with intraoperative intraluminal endoscopic assistance (IVEA), while 43 (58.1 %) people in the control group underwent diverticulectomy without IVEA. Intraoperatively, at the stage of discovering diverticulum, the endoscopist applied transillumination and air insufflation in the cavity of the diverticulum, followed by controlling the mobilization of diverticulum. At the resection stage, the completeness of the surgical removal was controlled, along with the absence of esophageal lumen narrowing after sewing the neck of the diverticulum using a linear stapler.Results. The average duration of the operation in patients with Zenker’s diverticula and those in the control group was 45.5 ± 8.8 min and 73.8 ± 12.7 min (p < 0.05), respectively. In patients with the diverticula of the middle and lower third of the esophagus, the average surgery duration was equal to 120.3 ± 11.2 min and 150.5 ± 17.3 (p <0.05) min in the main and control groups, respectively. Radiological examination 2–3 days after surgery revealed no complications in the main group. In the control group, 2 (4.7 %) patients showed a small leakage of the contrast agent outside the esophagus (stopped conservatively). Signs of mild dysphagia when taking solid foods were detected in 1 (2.4 %) patient of the control group. This condition was associated with excessive ingress of the esophageal wall into the apparatus suture, which led to a slight narrowing of its lumen. No patients with dysphagia in the postoperative period were recorded in the main group. Conclusion: The combination of surgical treatment of esophageal diverticula with IVEA allows the duration of surgery to be optimized, deformation of the esophageal lumen to be avoided, possible complications to be minimized, thereby improving the results of surgical treatment