Knowledge mapping and research hotspots of immunotherapy in renal cell carcinoma: A text-mining study from 2002 to 2021

BackgroundRenal cell carcinoma (RCC) is one of the most lethal urological malignancies, and because early-stage RCC is asymptomatic, many patients present metastatic diseases at first diagnosis. With the development of immunotherapy, the treatment of RCC has entered a new stage and has made a series of progress. This study mainly outlines the knowledge map and detects the potential research hotspots by using bibliometric analysis.MethodsPublications concerning RCC immunotherapy from 2002 to 2021 in the Web of Science Core Collection were collected. Visualization and statistical analysis were mainly performed by freeware tools VOSviewer, CiteSpace, R software, and Microsoft Office Excel 2019.ResultsA total of 3,432 papers were collected in this study, and the annual number of papers and citations showed a steady growth trend. The United States is the leading country with the most high-quality publications and is also the country with the most international cooperation. The University of Texas MD Anderson Cancer Center is the most productive organization. The Journal of Clinical Oncology is the highest co-cited journal, and Brian I. Rini is both the most prolific author and the author with the largest centrality. The current research hotspots may be focused on “immune checkpoint inhibitors (ICIs),” “PD-1,” and “mammalian target of rapamycin.”ConclusionImmunotherapy has a bright future in the field of RCC treatment, among which ICIs are one of the most important research hotspots. The main future research directions of ICI-based immunotherapy may focus on combination therapy, ICI monotherapy, and the development of new predictive biomarkers

Inverse Aerodynamic Optimization Considering Impacts of Design Tip Speed Ratio for Variable-Speed Wind Turbines

Because of the slow dynamic behavior of the large-inertia wind turbine rotor, variable-speed wind turbines (VSWTs) are actually unable to keep operating at the design tip speed ratio (TSR) during the maximum power point tracking (MPPT) process. Moreover, it has been pointed out that although a larger design TSR can increase the maximum power coefficient, it also greatly prolongs the MPPT process of VSWTs. Consequently, turbines spend more time operating at the off-design TSRs and the wind energy capture efficiency is decreased. Therefore, in the inverse aerodynamic design of VSWTs, the static aerodynamic performance (i.e., the maximum power coefficient) and the dynamic process of MPPT should be comprehensively modeled for determining an appropriate design TSR. In this paper, based on the inverse design method, an aerodynamic optimization method for VSWTs, fully considering the impacts of the design TSR on the static and dynamic behavior of wind turbines is proposed. In this method, to achieve higher wind energy production, the design TSR, chord length and twist angle are jointly optimized, which is structurally different from the conventional separated design procedure. Finally, the effectiveness of the proposed method is validated by simulation results based on the Bladed software