Evaluation of blood transfusion rate in obstetric patients

Objectives: The aim of this study was to analyse the obstetric patients who underwent transfusion in the gynecology and obstetrics clinic. Material and methods: Obstetric patients who underwent a blood transfusion in the peripartum period were included in the study. A total of 213 patients who needed blood transfusion were identified. Patients' age, gravida, parity, gestational week, delivery types, blood transfusion indication and time, transfusion rate, blood products used, number of transfusions, peripartum hysterectomy status, neonatal APGAR scores and hemoglobin (Hb), hematocrit (Hct), red blood cell (RBC), platelet (Plt) values which counted before and after transfusion were recorded by scanning patient files from the hospital registry system. Results: The overall blood transfusion rate of the patients who gave birth in our clinic was 2.51%. Uterine atony (50.7%) and chronic anemia (32.9%) were found as the most frequent indications of blood transfusion in the patients included in the study. Antenatal mean Hb of all transfusion patients was 9.8; postpartum mean Hb was 8.2. Pre-transfusion mean Hb, RBC, Hct, Plt values calculated as 7, 3.9, 30.3, 245.2, respectively; post-transfusion mean Hb, RBC, Hct, Plt values were 9, 3.52, 27.5, 215.1, respectively. Conclusions: Due to blood replacement, supply difficulties and transfusion complications, the profit-loss relationship should be individualized and clearly demonstrated before it is applied to the patient. In unpredictable obstetric situations that cause bleeding, staying up to date on current guidelines on pharmacological, hematological and surgical interventions and having an active blood transfusion center in the healthcare provider is very important in reducing maternal mortality and morbidity rates

Role of Vitamin B12 and Vitamin D levels in intrahepatic cholestasis of pregnancy and correlation with total bile acid

This study aimed to evaluate the relationship between intrahepatic cholestasis of pregnancy (ICP) and Vitamin D and B12 levels. The study was a retrospective, cross-sectional, case–control study that evaluated 92 ICP cases and 102 pregnant women without any additional disease. ICP cases were grouped as mild and severe according to their total bile acid (TBA) levels, and their relationship with Vitamin D and B12 levels and perinatal outcomes was evaluated. Vitamin D and B12 levels of the ICP group were significantly lower than those of the control group. There was a moderate negative correlation between TBA and Vitamin D levels and a low negative correlation between TBA and Vitamin B12 levels. Adverse neonatal outcomes were significantly higher in the severe ICP group than in the mild ICP group. IMPACT STATEMENT What is already known on this subject? The pathophysiology of ICP, which can lead to adverse perinatal outcomes, is not yet fully understood, and there is no preventive treatment. What do the results of this study add? This study showed that Vitamins B12 and D levels were low in women with ICP and that TBA levels were negatively correlated with Vitamin D and B12 levels. What are the implications of these findings for clinical practice and/or further research? This study may guide future studies in terms of explaining the etiopathogenesis of ICP and developing treatment options