10 research outputs found
Sex Hormone Regulation of Rat Organic Anion Transporter 3 (rOAT3) Expression in Rat Kidney
- Author
- Inui K., Masuda, S. and Saito, H.
- ISERN J
- Kojima R., Sekine, T., Kawachi, M., Cha, S. H., Suzuki, Y. and Endou, H.
- Konig J., Cui, Y., Nies, A. T. and Keppler, D.
- Lu R., Kanai, N., Bao, Yi, Wolkoff, A. W. and Schuster, V. L.
- Saito H., Masuda, S. and Inui, K.
- Tojo A., Sekine, T., Nakajima, N., Hosoyamada, M., Kanai, Y., Kimura, K. and Endou, H.
- Publication venue
- 'Pharmaceutical Society of Japan'
- Publication date
- 01/01/2003
- Field of study
Human Organic Anion Transporter 4 Is a Renal Apical Organic Anion/Dicarboxylate Exchanger in the Proximal Tubules
- Author
- BABU E
- Burckhardt G Bahn A, Wolff NA
- CHA S H
- DANTZLER W H
- ENOMOTO A
- Hosoyamada M Obinata M, Suzuki H, Endou H
- Hosoyamada M Sekine T, Kanai Y, Endou H
- Kellie AE Smith ER
- Moller JV Sheikh MI
- Pritchard JB Miller DS
- Roch-Ramel F Guisan B, Schild L
- Schmitt C Burckhardt G
- Sekine T Cha SH, Endou H
- Sweet DH Chan LM, Walden R, Yang XP, Miller DS, Pritchard JB
- van Aubel RAMH Peters JGP, Masereeuw R, van Os CH, Russel FGM
- Wright K Collins DC, Musey PI, Preedy JRK
- Publication venue
- 'Japanese Pharmacological Society'
- Publication date
- 01/01/2004
- Field of study
Expression of Human Organic Anion Transporters in the Choroid Plexus and Their Interactions With Neurotransmitter Metabolites
- Author
- APIWATTANAKUL N
- CHA S H
- Day R Quinn D, Williams K, Handel M, Brooks P
- GAO B
- Gibbs JE Thomas SA
- Gironi A Seghieri G, Niccolai M, Mammini P
- Hosoyamada M Sekine T, Kanai Y, Endou H
- Reid G Wolff NA, Dautzenberg FM, Burckhardt G
- Safrin S
- Sweet DH Chan LM, Walden R, Yang XP, Miller DS, Pritchard JB
- Tojo A Sekine T, Nakajima N, et al
- Publication venue
- 'Japanese Pharmacological Society'
- Publication date
- 01/01/2003
- Field of study
A Beneficial Interaction between Imipenem and Piperacillin Possibly through Their Renal Excretory Process
- Author
- Burckhardt B. C. Burckhardt G.
- Burgess D. S. Frei C. R.
- Crljen V. Sabolic I., Susac J., Appenroth D., Herak-Kramberger C. M., Ljubojevec M., Anzai N., Antolovic R., Burckhardt G., Fleck C., Sabolic I.
- HAYASHI T
- Hayashi T. Watanabe Y., Kumano K., Kitayama R., Yasuda T., Saikawa I., Katahira J., Kumada T., Shimizu K.
- Hiroko Fujisaki
- Hiroshi Saitoh
- HIROUCHI Y
- Hitoshi Sekikawa
- Jaruratanasirikul S. Raungsri N., Punyo J., Sriwiriyajan S.
- Masako Oda
- Michiya Kobayashi
- MOUTON J W
- Takeda M. Narikawa S., Hosoyamada M., Cha S. H., Sekine T., Endou H.
- Toru Gyotoku
- Wedeen R. P. Weiner B.
- Whitley A. C. Sweet D. H., Walle T.
- Publication venue
- 'Pharmaceutical Society of Japan'
- Publication date
- 01/01/2006
- Field of study
Renal urate handling: Clinical relevance of recent advances
- Author
- A Enomoto
- Atsushi Enomoto
- AY Hung
- D Prabhakaran
- DA Sica
- DC Hooper
- DH Kang
- E Gopal
- F Komoda
- F Roch-Ramel
- F Roch-Ramel
- H Kaur
- H Kimura
- H Kimura
- H Koepsell
- Hitoshi Endou
- I Hisatome
- I Ishikawa
- JK Maesaka
- JY Yeun
- K Ichida
- K Ichida
- K Zandi-Nejad
- KK Dev
- L Rampoldi
- M Hosoyamada
- M Hosoyamada
- M Shichiri
- M Tanaka
- MA Rafey
- MS Lipkowitz
- N Anzai
- N Bakhiya
- N Iwai
- Naohiko Anzai
- O Kocher
- OI Aruoma
- P Jutabha
- RA Aubel Van
- RG Abramson
- RJ Johnson
- RW Berlinger
- S Ekaratanawong
- SH Cha
- SH Cha
- SV Spitsin
- T Igarashi
- T Li
- T Murakami
- T Sekine
- Y Hellsten
- Y Kikuchi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Altered Brain Penetration of Diclofenac and Mefenamic Acid, but Not Acetaminophen, in Shiga-Like Toxin II-Treated Mice
- Author
- Choudhuri S Cherrington NJ, Li N, Klaassen CD
- Emoto A Ushigome F, Koyabu N, Kajiya H, Okabe K, Satoh S, et al
- GAO B
- Graff CL Pollack GM
- Ichiyama T Isumi H, Ozawa H, Matsubara T, Morishima T, Furukawa S
- Kasai T Togashi T, Morishima T
- Kawada J Kimura H, Ito Y, Hara S, Iriyama M, Yoshikawa T, et al
- Kawashima H Watanabe Y, Morishima T, Togashi T, Yamada N, Kashiwagi Y, et al
- Kita E Yunou Y, Kurioka T, Harada H, Yoshikawa S, Mikasa K, et al
- Kitaichi K Nakayama H, Ueyama J, Nadai M, Baba K, Takagi K, et al
- Kojima R Sekine T, Kawachi M, Cha SH, Suzuki Y, Endou H
- Lee W Kim RB
- MORITA N
- Strazielle N Khuth ST, Murat A, Chalon A, Giraudon P, Belin MF, et al
- SUGIYAMA D
- Sun H Dai H, Shaik N, Elmquist WF
- Theron D Barraud de Lagerie S, Tardivel S, Pelerin H, Demeuse P, Mercier C, et al
- Zhao YL Cen XB, Ito M, Yokoyama K, Takagi K, Kitaichi K, et al
- Zhao YL Du J, Kanazawa H, Cen XB, Takagi K, Kitaichi K, et al
- Zhao YL Du J, Kanazawa H, Sugawara A, Takagi K, Kitaichi K, et al
- Publication venue
- 'Japanese Pharmacological Society'
- Publication date
- 01/01/2005
- Field of study
Advances in the Cell Biology of Transport via the Inner Blood-Retinal Barrier: Establishment of Cell Lines and Transport Functions
- Author
- Alm A. Tö
- Alm A. Tö
- Alm A. Tö
- Asashima T. Iizasa H., Terasaki T.
- BenEzra D. Maftzir G.
- Bowman P. D. Betz A. L., Goldstein
- Cogan D. G. Kuwabara T.
- Cornford E.M.
- Cunha-Vaz J. G.
- Cunha-Vaz J. G. Maurice D.
- Dollery C. T. Henkind P., Orme M.
- Engler C. B. Sander B., Larsen M.,
- Ennis S. R. Johnson J. E., Pautler
- Friedman P. A. Zeidel M. L.
- Gao B. Wenzel A., Grimm C., Vavric
- Giles J.
- Goldman E. E.
- Goldstein G. W. Betz A. L.
- Harris A. Bingaman D. P., Ciulla T
- Hosoya K. Takashima T., Tetsuka K.
- Ohtsuki S. Tachikawa M., Takanaga
- Pardridge W. M.
- Philp N. J. Yoon H., Grollman E. F
- Sarthy V. P. Brodjian S. J., Dutt
- Schnaudigel O.
- Sekine T. Cha S. H., Endou H.
- Stewart P. A. Tuor U. I.
- Tö
- Takata K. Kasahara T., Kasahara M.
- Tomi M. Abukawa H., Nagai Y., Hata
- Tomi M. Hosoya K., Takanaga H., Oh
- Vannas-Sulonen K. Sipila I., Vanna
- Walters H. C. Craddock A. L., Fuse
- Woodford B. J. Tso M. O., Lam K. W
- Wyss M. Kaddurah-Daouk R.
- Publication venue
- 'Pharmaceutical Society of Japan'
- Publication date
- 01/01/2005
- Field of study
Uric Acid Causes Vascular Smooth Muscle Cell Proliferation by Entering Cells via a Functional Urate Transporter
- Author
- Alderman MH
- Andrew M. Kahn
- Beck L
- Cha SH
- Culleton BF
- Culleton BF
- Dobson A
- Duk-Hee Kang
- Feng L
- Hitoshi Endou
- Ichida K
- John Kanellis
- Johnson RJ
- Jossa F
- Kanellis J
- Khosla UM
- Kimura H
- Knorr BA
- Leal-Pinto E
- Leal-Pinto E
- Lili Feng
- Lin Han
- Lipkowitz MS
- Makoto Hosoyamada
- Mazzali M
- Mazzali M
- Michael Lipkowitz
- Motohashi H
- Nakagawa T
- Ohno I
- Ping Li
- Race JE
- Rao GN
- Richard J. Johnson
- Roch-Ramel F
- Roch-Ramel F
- Ruth Abramson
- Sanchez-Lozada LG
- Sanchez-Lozada LG
- Sekine T
- Selby JV
- Sundstrom J
- Susumu Watanabe
- Syrjanen J
- Takahiko Nakagawa
- Talbott JH
- Vaccarino V
- Van Aubel RAMH
- Verdecchia P
- Wei Mu
- Xiaosen Ouyang
- Zhang S
- Publication venue
- 'S. Karger AG'
- Publication date
- Field of study
Renal Drug Transporters and Drug Interactions.
- Author
- A Allen
- A Amphoux
- A Aslamkhan
- A Azzariti
- A Brandoni
- A Collett
- A Courtois
- A Crowe
- A Dahan
- A Dahan
- A Dahan
- A Dahlin
- A D’Emanuele
- A Enomoto
- A Enomoto
- A Futatsugi
- A Gaowa
- A Geick
- A Gupta
- A Hamada
- A Horie
- A Kamizono
- A Kawase
- A Koenen
- A Komatsuda
- A Kunze
- A Lazar
- A Lespine
- A Maeda
- A Maeda
- A McCormick
- A Milane
- A Mulgaonkar
- A Nakayama
- A Nies
- A Oka
- A Ose
- A Owen
- A Pawarode
- A Poirier
- A Rizwan
- A Servais
- A Soldner
- A Somogyi
- A Somogyi
- A Somogyi
- A Somogyi
- A Vildhede
- A Yamada
- A Yamada
- A Yonezawa
- A Yonezawa
- AA El-Sheikh
- AA Ela El
- AA Somogyi
- AA Somogyi
- AAK El-Sheikh
- AAK El-Sheikh
- AAK El-Sheikh
- AAK El-Sheikh
- AB Shapiro
- AE Busch
- AE Herwaarden van
- AE Kim
- AG Hotchkiss
- AH Schinkel
- AH Schinkel
- AH Schinkel
- AJ Dudley
- AJ Dudley
- AJ Scheen
- AL Dzierlenga
- AL VanWert
- AL VanWert
- AL Walker
- AM Al-Mohizea
- AM Bergman
- AM Hecken van
- AN Shaik
- Anton Ivanyuk
- AR Asif
- AS Mulato
- AS Ray
- AS Windass
- AS Windass
- AT Nies
- AT Wolman
- B Astorga
- B Feng
- B Feng
- B Fleisher
- B Greiner
- B Grover
- B Grover
- B Haenisch
- B Poller
- B Wenge
- BAC Acker van
- BC Burckhardt
- BC Ferslew
- BG Hardy
- BG Hardy
- BH Long
- BJ Gurley
- BL Lum
- BL Mason
- BM Schmitt
- BP Kearney
- BR Green
- C Chen
- C Chen
- C Chu
- C Fahrmayr
- C Fellner
- C Grammen
- C Hilgendorf
- C Jacobs
- C Jagannath
- C Kasserra
- C Kyrklund
- C Li
- C Luna-Tortós
- C Marzolini
- C Min-Koo
- C Pauli-Magnus
- C Pauli-Magnus
- C Pauli-Magnus
- C Pontier
- C Schmitt
- C Srimaroeng
- C Srimaroeng
- C Wandel
- C Wandel
- C Wang
- C Woodland
- C Xu
- C Zhang
- C Zhang
- C-H Ho
- CA Flynn
- CA Quezada
- CA Stanley
- CB Landersdorfer
- CB Landersdorfer
- CC Bridges
- CC Kuo
- CC Wong
- CC Wong
- CC Wong
- CE Frost
- CF Higgins
- CG Patel
- CGL Lee
- CH Rammelkamp
- CH Storch
- CL Noble
- CL Ronchera
- CO Kim
- Consortium IT
- CR Hill
- CR Yates
- CS Karyekar
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- CV Fletcher
- D Capone
- D Cihalova
- D Devineni
- D Durr
- D Gründemann
- D Gründemann
- D Gründemann
- D Gründemann
- D Iusuf
- D Jung
- D Keppler
- D Lawlor
- D Li
- D Miura
- D Overbosch
- D Schrenk
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- D Wang
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- DH Sweet
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- DJ Tompson
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- DS Miller
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- DW Boulton
- E Babu
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- E Gozalpour
- E Kamiyama
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- E Pasquier
- E Rytting
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- J Yin
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- J Zheng
- J Zong
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- JB Pritchard
- JD Allen
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- Jérôme Biollaz
- K Bleasby
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- S Matsushima
- S Matsushima
- S Micuda
- S Misaka
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- S Neuhoff
- S Noguchi
- S Ohnishi
- S Ohtsuki
- S Ohtsuki
- S Peters
- S Rebello
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- S Sun
- S Takusagawa
- S Tokuhiro
- S Tsuruoka
- S Vaidyanathan
- S Vautier
- S Velamakanni
- S Wada
- S Waldorff
- S Waldorff
- S Watanabe
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- SP Spina
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- SS Hong
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- T Ando
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- T Cihlar
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- T Giessmann
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- T Hashimoto
- T Hirano
- T Ikegawa
- T Imaoka
- T Ito
- T Ito
- T Ito
- T Itoh
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- T Kosoglou
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- T Maeda
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- T Mikkaichi
- T Mikkaichi
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- T Nakamura
- T Nakamura
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- T Nakatani-Freshwater
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- T Ohtomo
- T Rau
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- T Sato
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- Y Yamasaki
- Y Zhang
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- Y Zhu
- Y-F Cheng
- Y-H Han
- Y-H Zhang
- Y-J Piao
- YA Chen
- YH Oh
- YH Peng
- YR Ma
- Z Cheng
- Z Gai
- Z Li
- Z Shen
- Z Tong
- Z Yang
- Z-J Wang
- ZS Chen
- ZS Chen
- ZS Chen
- ZS Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/08/2017
- Field of study
Transporters in proximal renal tubules contribute to the disposition of numerous drugs. Furthermore, the molecular mechanisms of tubular secretion have been progressively elucidated during the past decades. Organic anions tend to be secreted by the transport proteins OAT1, OAT3 and OATP4C1 on the basolateral side of tubular cells, and multidrug resistance protein (MRP) 2, MRP4, OATP1A2 and breast cancer resistance protein (BCRP) on the apical side. Organic cations are secreted by organic cation transporter (OCT) 2 on the basolateral side, and multidrug and toxic compound extrusion (MATE) proteins MATE1, MATE2/2-K, P-glycoprotein, organic cation and carnitine transporter (OCTN) 1 and OCTN2 on the apical side. Significant drug-drug interactions (DDIs) may affect any of these transporters, altering the clearance and, consequently, the efficacy and/or toxicity of substrate drugs. Interactions at the level of basolateral transporters typically decrease the clearance of the victim drug, causing higher systemic exposure. Interactions at the apical level can also lower drug clearance, but may be associated with higher renal toxicity, due to intracellular accumulation. Whereas the importance of glomerular filtration in drug disposition is largely appreciated among clinicians, DDIs involving renal transporters are less well recognized. This review summarizes current knowledge on the roles, quantitative importance and clinical relevance of these transporters in drug therapy. It proposes an approach based on substrate-inhibitor associations for predicting potential tubular-based DDIs and preventing their adverse consequences. We provide a comprehensive list of known drug interactions with renally-expressed transporters. While many of these interactions have limited clinical consequences, some involving high-risk drugs (e.g. methotrexate) definitely deserve the attention of prescribers
Renal Drug Transporters and Drug Interactions
- Author
- A Allen
- A Amphoux
- A Aslamkhan
- A Azzariti
- A Brandoni
- A Collett
- A Courtois
- A Crowe
- A Dahan
- A Dahan
- A Dahan
- A Dahlin
- A D’Emanuele
- A Enomoto
- A Enomoto
- A Futatsugi
- A Gaowa
- A Geick
- A Gupta
- A Hamada
- A Horie
- A Kamizono
- A Kawase
- A Koenen
- A Komatsuda
- A Kunze
- A Lazar
- A Lespine
- A Maeda
- A Maeda
- A McCormick
- A Milane
- A Mulgaonkar
- A Nakayama
- A Nies
- A Oka
- A Ose
- A Owen
- A Pawarode
- A Poirier
- A Rizwan
- A Servais
- A Soldner
- A Somogyi
- A Somogyi
- A Somogyi
- A Somogyi
- A Vildhede
- A Yamada
- A Yamada
- A Yonezawa
- A Yonezawa
- AA El-Sheikh
- AA Ela El
- AA Somogyi
- AA Somogyi
- AAK El-Sheikh
- AAK El-Sheikh
- AAK El-Sheikh
- AAK El-Sheikh
- AB Shapiro
- AE Busch
- AE Herwaarden van
- AE Kim
- AG Hotchkiss
- AH Schinkel
- AH Schinkel
- AH Schinkel
- AJ Dudley
- AJ Dudley
- AJ Scheen
- AL Dzierlenga
- AL VanWert
- AL VanWert
- AL Walker
- AM Al-Mohizea
- AM Bergman
- AM Hecken van
- AN Shaik
- Anton Ivanyuk
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- AS Ray
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- AS Windass
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- AT Wolman
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- C Chen
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- SP Pushpakom
- SP Spina
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- SW Yee
- T Ando
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- T Cihlar
- T Cihlar
- T Cihlar
- T Fukuda
- T Giessmann
- T Giessmann
- T Hashida
- T Hashimoto
- T Hirano
- T Ikegawa
- T Imaoka
- T Ito
- T Ito
- T Ito
- T Itoh
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- T Komatsu
- T Kosoglou
- T Kurata
- T Kurata
- T Lan
- T Maeda
- T Makino
- T Mikkaichi
- T Mikkaichi
- T Mikkaichi
- T Minematsu
- T Minematsu
- T Miyama
- T Mizuno
- T Nakada
- T Nakamura
- T Nakamura
- T Nakatani-Freshwater
- T Nakatani-Freshwater
- T Nishijima
- T Ohtomo
- T Rau
- T Saeki
- T Sato
- T Sekine
- T Sekine
- T Shibayama
- T Shiga
- T Shiga
- T Takubo
- T Terada
- T Watanabe
- T Yamazaki
- T Yasujima
- T Yokooji
- T Zoto
- TB Stage
- TB Tjandra-Maga
- TB Tjandramaga
- TF Solbach
- Thierry Buclin
- TJ Urban
- TN Kakuda
- TN Winter
- TS Bekaii-Saab
- TS Tracy
- U Jaehde
- U Roy
- U Schmitt
- V Gorboulev
- V Juhasz
- V Lecureur
- V Lecureur
- V Martin
- V Sikri
- V Vallon
- V Vallon
- VA Eagling
- VC Oliveira Almeida De
- VJ Wacher
- VL Damaraju
- VR Challa
- W Kim
- W Liu
- W Mueck
- W Siegmund
- W Wang
- W Yamashiro
- W Zhang
- W-Q Chen
- WJ Sam
- WM Suhre
- X Bossuyt
- X Chu
- X Huo
- X Jin
- X Li
- X Ming
- X Ming
- X Ming
- X Wang
- X Wu
- X Wu
- X Wu
- X Wu
- X Wu
- X Zhang
- X Zheng
- XJ He
- XY Chu
- Y Adachi
- Y Cheng
- Y Feng
- Y Fujita
- Y Fukuda
- Y Hagos
- Y Hagos
- Y Hagos
- Y Hagos
- Y Hashiguchi
- Y Honda
- Y Imamura
- Y Imamura
- Y Kato
- Y Kido
- Y Kido
- Y Kobayashi
- Y Kurata
- Y Matsuo
- Y Matsuo
- Y Moriyama
- Y Nagasaka
- Y Nozaki
- Y Nozaki
- Y Nozaki
- Y Pan
- Y Shibayama
- Y Shibayama
- Y Shima
- Y Shirasaka
- Y Shirasaka
- Y Shitara
- Y Shitara
- Y Shu
- Y Su
- Y Sugimoto
- Y Tanaka
- Y Tanigawara
- Y Tanihara
- Y Tanihara
- Y Tomita
- Y Tschuppert
- Y Uchida
- Y Urakami
- Y Urakami
- Y Urakami
- Y Urakami
- Y Urakami
- Y Uwai
- Y Uwai
- Y Uwai
- Y Uwai
- Y Uwai
- Y Uwai
- Y Uwai
- Y Uwai
- Y Uwai
- Y Uwai
- Y Uwai
- Y Uwai
- Y Uwai
- Y Yamakawa
- Y Yamasaki
- Y Zhang
- Y Zhang
- Y Zhou
- Y Zhu
- Y-F Cheng
- Y-H Han
- Y-H Zhang
- Y-J Piao
- YA Chen
- YH Oh
- YH Peng
- YR Ma
- Z Cheng
- Z Gai
- Z Li
- Z Shen
- Z Tong
- Z Yang
- Z-J Wang
- ZS Chen
- ZS Chen
- ZS Chen
- ZS Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study