23 research outputs found

    ADAMTS13によるvon Willebrand因子の切断増加は、本態性血小板血症患者における後天性von Willebrand症候群の発症に強く寄与する。

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    Background: Patients with essential thrombocythemia (ET) often experience bleeding associated with acquired von Willebrand syndrome (AVWS) when the platelet count is markedly increased. Objective: We investigated whether von Willebrand factor (VWF) degradation is enhanced in patients with ET. Methods: Seventy patients with ET underwent VWF multimer (VWFM) analysis and measurement of VWF-related parameters. We calculated the VWFM index, defined as the ratio of intensities of a patient's molecular weight-categorized VWFMs, and those of a healthy subject's, using densitometric analysis. VWF degradation product (DP) was measured via ELISA using a monoclonal antibody that specifically recognizes Y1605 at the C-terminal boundary, which is exposed following ADAMTS13-mediated cleavage of the Y1605-M1606 bond of the VWF A2 domain. Results: Patients with higher platelet counts had a significantly reduced high molecular weight (HMW)-VWFM index and an increased VWF-DP: VWF antigen (Ag) ratio compared to those with lower platelet counts. On multivariate analysis, the VWF-DP/ VWF:Ag ratio was an independent predictor of the HMW-VWFM index. Patients who underwent cytoreductive therapy had a significantly higher HMW-VWFM index and lower VWF-DP/ VWF:Ag ratio than those who did not. Among individual patients, there was also a significant increase in the HMW-VWFM index and a decrease in the VWF-DP/ VWF:Ag ratio after cytoreductive therapy compared to pre-therapy values. Conclusion: In patients with ET, an increased platelet count is associated with enhanced cleavage of VWF at the Y1605-M1606 bond, primarily by ADAMTS13, leading to AVWS. Cytoreductive therapy reduces the platelet count, prevents excessive VWF cleavage, and improves VWFM distributions.博士(医学)・甲第881号・令和5年3月15

    Development of a Hyperspectral Sensor on UAV for Biomass estimation at Costal Zone

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    Use of spectral reflectance from a compact spectrometer to assess chlorophyll content in Zizania latifolia

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    Hyperspectral remote sensing is frequently used to monitor chlorophyll content, an important characteristic for assessing photosynthetic ability, health and defence against a variety of degenerative diseases. To obtain hyperspectral data, field portable spectroradiometers, such as Ocean Optics Hyperspectral Vis-NIR spectroradiometers and Analytical Spectral Devices FieldSpec series, have been widely used. The development of an affordable hyperspectral remote sensing system would be advantageous. Highly sensitive, affordable and cost-effective finger-tip size spectrometers have recently been released. In this study we investigate the potential of hyperspectral data obtained from such a compact spectrometer (C12880MA-10, Hamamatsu Photonics) for estimating chlorophyll content in Zizania latifolia. We also tested the efficacy of five pre-processing techniques (first derivative reflectance, continuum-removal transformation, de-trending, multiplicative scatter correction and standard normal variate) in conjunction with five machine learning algorithms

    Evaluation of a One-Dimensional Convolution Neural Network for Chlorophyll Content Estimation Using a Compact Spectrometer

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    Leaf chlorophyll content is used as a major indicator of plant stress and growth, and hyperspectral remote sensing is frequently used to monitor the chlorophyll content. Hyperspectral reflectance has been used to evaluate vegetation properties such as pigment content, plant structure and physiological features using portable spectroradiometers. However, the prices of these devices have not yet decreased to consumer-affordable levels, which prevents widespread use. In this study, a system based on a cost-effective fingertip-sized spectrometer (Colorcompass-LF, a total price for the proposed solution was approximately 1600 USD) was evaluated for its ability to estimate the chlorophyll contents of radish and wasabi leaves and was compared with the Analytical Spectral Devices FieldSpec4. The chlorophyll contents per leaf area (cm2) of radish were generally higher than those of wasabi and ranged from 42.20 to 94.39 μg/cm2 and 11.39 to 40.40 μg/cm2 for radish and wasabi, respectively. The chlorophyll content was estimated using regression models based on a one-dimensional convolutional neural network (1D-CNN) that was generated after the original reflectance from the spectrometer measurements was de-noised. The results from an independent validation dataset confirmed the good performance of the Colorcompass-LF after spectral correction using a second-degree polynomial, and very similar estimation accuracies were obtained for the measurements from the FieldSpec4. The coefficients of determination of the regression models based on 1D-CNN were almost same (with R2 = 0.94) and the ratios of performance to deviation based on reflectance after spectral correction using a second-degree polynomial for the Colorcompass-LF and the FieldSpec4 were 4.31 and 4.33, respectively

    Human Detection Based on Active Infrared Illumination

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