1 research outputs found
Intradialytic cycling does not exacerbate microparticles or circulating markers of systemic inflammation in haemodialysis patients
PurposePatients receiving haemodialysis (HD) display elevated circulating microparticle (MP) concentration, tissue factor (TF) expression and markers of systemic inflammation, though regular intradialytic cycling (IDC) may have a therapeutic effect. This study investigated the impact of regular, moderate-intensity IDC on circulating MPs and inflammatory markers in unit-based HD patients.MethodsPatients were cluster-randomised to intervention (nβ=β20, age: 51.4βΒ±β18.1 years, body mass: 77.6βΒ±β18.3 kg, meanβΒ±βSD) or no-exercise control (nβ=β20, 56.8βΒ±β14.0 years, 80.5βΒ±β26.5 kg). Intervention participants completed 30 min of moderate intensity (rating of perceived exertion [RPE] of 12β14) IDC, thrice weekly for 6 months. Pre-dialysis venous blood samples were obtained at 0, 3 and 6 months. Circulating MP phenotypes, cytokines, chemokine and MP TF expression were quantified using flow cytometry and cytometric bead array assays.ResultsDespite high exercise compliance (82%), no IDC-dependent effects were observed for any MP, cytokine or chemokine measure (pββ₯β0.051, Ξ·Ο2ββ€β0.399) other than TNF-Ξ± (pβ=β0.001, Ξ·Ο2β=β0.186), though no significance was revealed upon post hoc analysis.ConclusionSix months of regular, moderate-intensity IDC had no effect on MPs, cytokines or chemokines. This suggests that the exercise did not exacerbate thrombotic or inflammatory status, though further functional assays are required to confirm this.Trial registrationISRCTN1129707, prospectively registered on 05/03/2015.</div