26 research outputs found
Dynamics in Stationary, Non-Globally Hyperbolic Spacetimes
Classically, the dynamics in a non-globally hyperbolic spacetime is ill
posed. Previously, a prescription was given for defining dynamics in static
spacetimes in terms of a second order operator acting on a Hilbert space
defined on static slices. The present work extends this result by giving a
similar prescription for defining dynamics in stationary spacetimes obeying
certain mild assumptions. The prescription is defined in terms of a first order
operator acting on a different Hilbert space from the one used in the static
prescription. It preserves the important properties of the earlier one: the
formal solution agrees with the Cauchy evolution within the domain of
dependence, and smooth data of compact support always give rise to smooth
solutions. In the static case, the first order formalism agrees with second
order formalism (using specifically the Friedrichs extension). Applications to
field quantization are also discussed.Comment: 18 pages, 1 figure, AMSLaTeX; v2: expanded discussion of field
quantization, new Proposition 3.1, revised Theorem 4.2, corrected typos, and
updated reference
Critical Role of Macrophages and Their Activation via MyD88-NFκB Signaling in Lung Innate Immunity to Mycoplasma pneumoniae
Mycoplasma pneumoniae (Mp), a common cause of pneumonia, is associated with asthma; however, the mechanisms underlying this association remain unclear. We investigated the cellular immune response to Mp in mice. Intranasal inoculation with Mp elicited infiltration of the lungs with neutrophils, monocytes and macrophages. Systemic depletion of macrophages, but not neutrophils, resulted in impaired clearance of Mp from the lungs. Accumulation and activation of macrophages were decreased in the lungs of MyD88−/− mice and clearance of Mp was impaired, indicating that MyD88 is a key signaling protein in the anti-Mp response. MyD88-dependent signaling was also required for the Mp-induced activation of NFκB, which was essential for macrophages to eliminate the microbe in vitro. Thus, MyD88-NFκB signaling in macrophages is essential for clearance of Mp from the lungs
Quantum probes of timelike naked singularities in the weak field regime of f (R) global monopole spacetime
Phenotypes of infiltrating cells in trehalose dimycolate-induced interstitial pneumonitis
On well-posedness of the Cauchy problem for the wave equation in static spherically symmetric spacetimes
Modulation of intra-pulmonary TGF-b expression by mycophenolate mofetil in lupus prone MRL/lpr mice
Elevated Cytokine and Chemokine Levels and Prolonged Pulmonary Airflow Resistance in a Murine Mycoplasma pneumoniae Pneumonia Model: a Microbiologic, Histologic, Immunologic, and Respiratory Plethysmographic Profile
Because Mycoplasma pneumoniae is hypothesized to play an important role in reactive airway disease/asthma, a comprehensive murine model of M. pneumoniae lower respiratory infection was established. BALB/c mice were intranasally inoculated once with M. pneumoniae and sacrificed at 0 to 42 days postinoculation. All mice became infected and developed histologic evidence of acute pulmonary inflammation, which cleared by 28 days postinoculation. By contrast, M. pneumoniae persisted in the respiratory tract for the entire 42 days studied. Tumor necrosis factor alpha, gamma interferon, interleukin-6 (IL-6), KC (functional IL-8), MIP-1α, and MCP-1/JE concentrations were significantly elevated in bronchoalveolar lavage samples, whereas IL-4 and IL-10 concentrations were not significantly elevated. Pulmonary airflow resistance, as measured by plethysmography, was detected 1 day postinoculation and persisted even after pulmonary inflammation had resolved at day 28. Serum anti-M. pneumoniae immunoglobulin G titers were positive in all mice by 35 days. This mouse model provides a means to investigate the immunopathogenesis of M. pneumoniae infection and its possible role in reactive airway disease/asthma