The Hypanis Valles delta: The last highstand of a sea on early Mars?

One of the most contentious hypotheses in the geological history of Mars is whether the northern lowlands ever contained an oceanic water body. Arguably, the best evidence for an ocean comes from the presence of sedimentary fans around Mars' dichotomy boundary, which separates the northern lowlands from the southern highlands. Here we describe the palaeogeomorphology of the Hypanis Valles sediment fan, the largest sediment fan complex reported on Mars (area >970 km2). This has an extensive catchment (4.6 x 105 km2) incorporating Hypanis and Nanedi Valles, that we show was active during the late-Noachian/early-Hesperian period (∼3.7 Ga). The fan comprises a series of lobe-shaped sediment bodies, connected by multiple bifurcating flat-topped ridges. We interpret the latter as former fluvial channel belts now preserved in inverted relief. Meter-scale-thick, sub-horizontal layers that are continuous over tens of kilometres are visible in scarps and the inverted channel margins. The inverted channel branches and lobes are observed to occur up to at least 140 km from the outlet of Hypanis Valles and descend ∼500 m in elevation. The progressive basinward advance of the channellobe transition records deposition and avulsion at the margin of a retreating standing body of water, assuming the elevation of the northern plains basin floor is stable. We interpret the Hypanis sediment fan to represent an ancient delta as opposed to a fluvial fan system. At its location at the dichotomy boundary, the Hypanis Valles fan system is topographically open to Chryse Planitia – an extensive plain that opens in turn into the larger northern lowlands basin. We conclude that the observed progradation of fan bodies was due to basinward shoreline retreat of an ancient body of water which extended across at least Chryse Planitia. Given the open topography, it is plausible that the Hypanis fan system records the existence, last highstand, and retreat of a large sea in Chryse Planitia and perhaps even an ocean that filled the northern plains of Mars

Making better use of local data in flood frequency estimation

Flood frequency estimates are an essential part of flood risk management. They are an important ingredient of many important decisions, informing the cost-effectiveness, design and operation of flood defences, flood mapping and planning decisions in flood risk areas. They also inform the National Flood Risk Assessment, the setting of insurance premiums and long-term investment planning. Methods described in the Flood Estimation Handbook (FEH) published in 1999, and many subsequent updates, are considered the industry standard for flood estimation in the UK. They are used extensively by hydrologists from both the public and private sectors. Flood frequency estimates – also known as design flood estimates – are associated with many sources of uncertainty. These hydrological uncertainties often constitute the most uncertain component in any flood study. Uncertainty can lead to difficulty in having confidence in the outputs of studies, whether these are for investment planning, insurance, asset design, development planning or other purposes. As a result, there is considerable benefit to be gained from any reduction in the uncertainty of flood frequency estimation. There are many supplementary sources of information that can help to refine estimates of design floods and potentially reduce uncertainty. Examples include long-term flood history, river level records, photographs of floods and information obtained from field visits. These and similar types of information are defined as ‘local data’. The FEH Local research project aimed to: quantify the uncertainty of design floods estimated from FEH methods develop procedures and guidance for incorporating local and historical data into flood estimation to reduce uncertainties The primary objective of this report is to describe the reviews and research carried out during the FEH Local project. Another output from the project was a document giving guidance to practitioners on how to estimate uncertainty in flood frequency and how to find and incorporate local data. The practitioner guidance, ‘Using Local Data to Reduce Uncertainty in Flood Frequency Estimation’, will be disseminated early in 2017. This report aims to avoid duplication with the practitioner guidance and so is intended mainly for those with an interest in the background to the methods presented in the guidance

An amphitropic cAMP-binding protein in yeast mitochondria

ABSTRACT: We describe the first example of a mitochondrial protein with a covalently attached phos-phatidylinositol moiety acting as a membrane anchor. The protein can be metabolically labeled with both stearic acid and inositol. The stearic acid label is removed by phospholipase D whereupon the protein with the retained inositol label is released from the membrane. This protein is a cAMP receptor of the yeast Saccharomyces cereuisiae and tightly associated with the inner mitochondrial membrane. However, it is converted into a soluble form during incubation of isolated mitochondria with Ca2+ and phospholipid (or lipid derivatives). This transition requires the action of a proteinaceous, N-ethylmaleimide-sensitive component of the intermembrane space and is accompanied by a decrease in the lipophilicity of the cAMP receptor. We propose that the component of the intermembrane space triggers the amphitropic behavior of the mitochondrial lipid-modified CAMP-binding protein through a phospholipase activity. Only in recent years specific fatty acids have been recog-nized to play important roles in the association of proteins with membranes. Both noncovalent and covalent interactions be-tween fatty acids and proteins have been reported. Among the latter are GTP-binding proteins (Molenaar et al., 1988)

Benevolent characteristics promote cooperative behaviour among humans

Cooperation is fundamental to the evolution of human society. We regularly observe cooperative behaviour in everyday life and in controlled experiments with anonymous people, even though standard economic models predict that they should deviate from the collective interest and act so as to maximise their own individual payoff. However, there is typically heterogeneity across subjects: some may cooperate, while others may not. Since individual factors promoting cooperation could be used by institutions to indirectly prime cooperation, this heterogeneity raises the important question of who these cooperators are. We have conducted a series of experiments to study whether benevolence, defined as a unilateral act of paying a cost to increase the welfare of someone else beyond one's own, is related to cooperation in a subsequent one-shot anonymous Prisoner's dilemma. Contrary to the predictions of the widely used inequity aversion models, we find that benevolence does exist and a large majority of people behave this way. We also find benevolence to be correlated with cooperative behaviour. Finally, we show a causal link between benevolence and cooperation: priming people to think positively about benevolent behaviour makes them significantly more cooperative than priming them to think malevolently. Thus benevolent people exist and cooperate more

Social media and education: reconceptualizing the boundaries of formal and informal learning

© 2015 Taylor & Francis. It is argued that social media has the potential to bridge formal and informal learning through participatory digital cultures. Exemplars of sophisticated use by young people support this claim, although the majority of young people adopt the role of consumers rather than full participants. Scholars have suggested the potential of social media for integrating formal and informal learning, yet this work is commonly under-theorized. We propose a model theorizing social media as a space for learning with varying attributes of formality and informality. Through two contrasting case studies, we apply our model together with social constructivism and connectivism as theoretical lenses through which to tease out the complexities of learning in various settings. We conclude that our model could reveal new understandings of social media in education, and outline future research directions

Paediatric early warning systems: not a simple answer to a complex question.

Paediatric early warning systems (PEWS) to reduce in-hospital mortality have been a laudable endeavour. Evaluation of their impact has rarely examined the internal validity of the components of PEWS in achieving desired outcomes. We highlight the assumptions made regarding the mode of action of PEWS and, as PEWS become more commonplace, this paper asks whether we really understand their function, process and outcome. [Abstract copyright: © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

Local and regional drivers influence how aquatic community diversity, resistance and resilience vary in response to drying

Disturbance events govern how the biodiversity of ecological communities varies in both space and time. In freshwater ecosystems, there is evidence that local and regional‐scale drivers interact to influence ecological responses to drying disturbances. However, most research provides temporal snapshots at the local scale, whereas few studies encompass a gradient of drying severity spanning multiple years. Using a dataset of rare spatiotemporal extent and detail, we demonstrate how independent and interacting local and regional‐scale factors drive shifts in the α and β diversities of communities in dynamic river ecosystems. We examined aquatic invertebrate assemblage responses to hydrological variability (as characterized by monthly observations of instream conditions) at 30 sites over a 12‐year period encompassing typical years and two severe drought disturbances. Sites varied in their disturbance regimes and hydrological connectivity at both local (i.e. site‐specific) and regional (i.e. river catchment) scales. Whereas α diversity was mainly influenced by local factors including flow permanence and the temporal extent of ponded and dry conditions, both temporal and spatial β diversities also responded to regional‐scale metrics such as the spatial extent of flow and hydrological connectivity. We observed stronger local negative responses for taxa with lower capacities to tolerate drying (i.e. resistance) and/or to recover after flow resumes (i.e. resilience), whereas taxa with functional traits promoting resilience made an increasing contribution to spatial β diversity as hydrological connectivity declined. As droughts increase in extent and severity across global regions, our findings highlight the functional basis of taxonomic responses to disturbance and connectivity, and thus advance understanding of how drying disturbances shape biodiversity in river networks. Our identification of the role of regional hydrological factors could inform catchment‐scale management strategies that support ecosystem resilience in a context of global change