Testing the GRACE follow-on triple mirror assembly

We report on the successful testing of the GRACE follow-on triple mirror assembly (TMA) prototype. This component serves to route the laser beam in a proposed follow-on mission to the Gravity Recovery and Climate Explorer (GRACE) mission, containing an optical instrument for space-based distance measurement between satellites. As part of this, the TMA has to meet a set of stringent requirements on both the optical and mechanical properties. The purpose of the TMA prototype testing is to establish the feasibility of the design, materials choice and fabrication techniques. Here we report on co-alignment testing of this device to the arc second (5 μrad) level and thermal alignment stability testing to 1 μ rad {{K}-1}

Complications of Peripherally Inserted Central Venous Catheters: A Retrospective Cohort Study

Background and Aim The use of venous catheters is a widespread practice, especially in oncological and oncohematological units. The objective of this study was to evaluate the complications associated with peripherally inserted central catheters (PICCs) in a cohort of patients. Materials and Methods In this retrospective cohort study, we included all patient carrying PICCs (n = 603) inserted at our institute between October 2010 and December 2013. The main variables collected were medical diagnosis, catheter care, location, duration of catheterization, reasons for catheter removal, complications, and nursing care. Complications were classified as infection, thrombosis, phlebitis, migration, edema, and/or ecchymosis. Results All patients were treated according to the same “nursing care” protocol. The incidence rate of complications was two cases per 1000 days of catheter duration. The most relevant complications were infection and thrombosis, both with an incidence of 0.17 cases per 1000 days of the total catheterization period. The total average duration of catheterization was 170 days [SD 6.06]. Additionally to “end of treatment” (48.42%) and “exitus”, (22.53%) the most frequent cause of removal was migration (displacement towards the exterior) of the catheter (5.80%). Conclusions PICCs are safe devices that allow the administration of long-term treatment and preserve the integrity of the venous system of the patient. Proper care of the catheter is very important to improve the quality life of patients with oncologic and hematologic conditions. Therefore, correct training of professionals and patients as well as following the latest scientific recommendations are particularly relevant

Testing the GRACE follow-on triple mirror assembly

We report on the successful testing of the GRACE follow-on triple mirror assembly (TMA) prototype. This component serves to route the laser beam in a proposed follow-on mission to the Gravity Recovery and Climate Explorer (GRACE) mission, containing an optical instrument for space-based distance measurement between satellites. As part of this, the TMA has to meet a set of stringent requirements on both the optical and mechanical properties. The purpose of the TMA prototype testing is to establish the feasibility of the design, materials choice and fabrication techniques. Here we report on co-alignment testing of this device to the arc second (5 μrad) level and thermal alignment stability testing to 1 μrad K-1

The design and construction of a prototype lateral-transfer retro-reflector for inter-satellite laser ranging

The Gravity Recovery and Climate Experiment (GRACE) mission, launched in 2002, is nearing an end, and a continuation mission (GRACE Follow-on) is on a fast-tracked development. GRACE Follow-on will include a laser ranging interferometer technology demonstrator, which will perform the first laser interferometric ranging measurement between separate spacecraft. This necessitates the development of lightweight precision optics that can operate in this demanding environment. In particular, this beam routing system, called the triple mirror assembly, for the GRACE Follow-on mission presents a significant manufacturing challenge. Here we report on the design and construction of a prototype triple mirror assembly for the GRACE Follow-on mission. Our constructed prototype has a co-alignment error between the incoming and outgoing beams of 9 μrad, which meets the requirement that this error must be less than 10 μrad

Long-term efficacy of T3 analogue triac in children and adults with MCT8 deficiency: a real-life retrospective cohort study

Context Patients with mutations in thyroid hormone transporter MCT8 have developmental delay and chronic thyrotoxicosis associated with being underweight and having cardiovascular dysfunction. Objective Our previous trial showed improvement of key clinical and biochemical features during 1-year treatment with the T3 analogue Triac, but long-term follow-up data are needed. Methods In this real-life retrospective cohort study, we investigated the efficacy of Triac in MCT8-deficient patients in 33 sites. The primary endpoint was change in serum T3 concentrations from baseline to last available measurement. Secondary endpoints were changes in other thyroid parameters, anthropometric parameters, heart rate, and biochemical markers of thyroid hormone action. Results From October 15, 2014 to January 1, 2021, 67 patients (median baseline age 4.6 years; range, 0.5-66) were treated up to 6 years (median 2.2 years; range, 0.2-6.2). Mean T3 concentrations decreased from 4.58 (SD 1.11) to 1.66 (0.69) nmol/L (mean decrease 2.92 nmol/L; 95% CI, 2.61-3.23; P < 0.0001; target 1.4-2.5 nmol/L). Body-weight-for-age exceeded that of untreated historical controls (mean difference 0.72 SD; 95% CI, 0.36-1.09; P = 0.0002). Heart-rate-for-age decreased (mean difference 0.64 SD; 95% CI, 0.29-0.98; P = 0.0005). SHBG concentrations decreased from 245 (99) to 209 (92) nmol/L (mean decrease 36 nmol/L; 95% CI, 16-57; P = 0.0008). Mean creatinine concentrations increased from 32 (11) to 39 (13) µmol/L (mean increase 7 µmol/L; 95% CI, 6-9; P < 0.0001). Mean creatine kinase concentrations did not significantly change. No drug-related severe adverse events were reported. Conclusions Key features were sustainably alleviated in patients with MCT8 deficiency across all ages, highlighting the real-life potential of Triac for MCT8 deficiency