23 research outputs found
Ammonia and nutritional therapy in the critically ill: when to worry, when to test and how to treat?
Hyperammonaemia is almost always develops in patients with severe liver failure and this remains the commonest cause of elevated ammonia concentrations in the ICU. Nonhepatic hyperammonaemia in ICU presents diagnostic and management challenges for treating clinicians. Nutritional and metabolic factors play an important role in the cause and management of these complex disorders. Nonhepatic hyperammonaemia causes such as drugs, infection and inborn errors of metabolism may be unfamiliar to clinicians and risk being overlooked. Although cirrhotic patients may tolerate marked elevations in ammonia, other causes of acute severe hyperammonaemia may result in fatal cerebral oedema. Any coma of unclear cause should prompt urgent measurement of ammonia and severe elevations warrant immediate protective measures as well as treatments such as renal replacement therapy to avoid life-threatening neurological injury. The current review explores important clinical considerations, the approach to testing and key treatment principles that may prevent progressive neurological damage and improve outcomes for patients with hyperammonaemia, especially from nonhepatic causes
Existing and emerging therapies for the treatment of invasive candidiasis and candidemia
Inducible metabolic pathway for citrate metabolism in case of major liver dysfunction: fact or fiction?
SCOPUS: le.jinfo:eu-repo/semantics/publishe
Is cortical perfusion a reliable marker for predicting septic acute kidney injury?
SCOPUS: le.jinfo:eu-repo/semantics/publishe
Hyperchloremia-associated acute chronic kidney injury: beware of confounders!
SCOPUS: le.jinfo:eu-repo/semantics/publishe
Hyperammonemia, the Last Indication of High-Volume Hemodiafiltration in Adult and Children: A Structured Review
Compared to NIPPV, HFNC is more dangerous regarding aerosol dispersion and contamination of healthcare personnel: we are not sure
Optimizing micafungin dosing in critically ill patients: what about extracorporeal therapies?
SCOPUS: le.jinfo:eu-repo/semantics/publishe