Chlamydia pneumoniae, overall and cardiovascular mortality in end-stage renal disease (ESRD)

n/

Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19.

Objectives To evaluate the strength of association between maternal and pregnancy characteristics and the risk of adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Methods Secondary analysis of a multinational, cohort study on all consecutive pregnant women with laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 2020 from 73 centers from 22 different countries. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite adverse fetal outcome, defined as the presence of either abortion (pregnancy loss before 22 weeks of gestations), stillbirth (intrauterine fetal death after 22 weeks of gestation), neonatal death (death of a live-born infant within the first 28 days of life), and perinatal death (either stillbirth or neonatal death). Logistic regression analysis was performed to evaluate parameters independently associated with the primary outcome. Logistic regression was reported as odds ratio (OR) with 95% confidence interval (CI). Results Mean gestational age at diagnosis was 30.6+/-9.5 weeks, with 8.0% of women being diagnosed in the first, 22.2% in the second and 69.8% in the third trimester of pregnancy. There were six miscarriage (2.3%), six intrauterine device (IUD) (2.3) and 5 (2.0%) neonatal deaths, with an overall rate of perinatal death of 4.2% (11/265), thus resulting into 17 cases experiencing and 226 not experiencing composite adverse fetal outcome. Neither stillbirths nor neonatal deaths had congenital anomalies found at antenatal or postnatal evaluation. Furthermore, none of the cases experiencing IUD had signs of impending demise at arterial or venous Doppler. Neonatal deaths were all considered as prematurity-related adverse events. Of the 250 live-born neonates, one (0.4%) was found positive at RT-PCR pharyngeal swabs performed after delivery. The mother was tested positive during the third trimester of pregnancy. The newborn was asymptomatic and had negative RT-PCR test after 14 days of life. At logistic regression analysis, gestational age at diagnosis (OR: 0.85, 95% CI 0.8-0.9 per week increase; pPeer reviewe

Risk Factors Associated with Adverse Fetal Outcomes in Pregnancies Affected by Coronavirus Disease 2019 (COVID-19): A Secondary Analysis of the WAPM study on COVID-19

To evaluate the strength of association between maternal and pregnancy characteristics and the risk of adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Secondary analysis of a multinational, cohort study on all consecutive pregnant women with laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 2020 from 73 centers from 22 different countries. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite adverse fetal outcome, defined as the presence of either abortion (pregnancy loss before 22 weeks of gestations), stillbirth (intrauterine fetal death after 22 weeks of gestation), neonatal death (death of a live-born infant within the first 28 days of life), and perinatal death (either stillbirth or neonatal death). Logistic regression analysis was performed to evaluate parameters independently associated with the primary outcome. Logistic regression was reported as odds ratio (OR) with 95% confidence interval (CI). Mean gestational age at diagnosis was 30.6\ub19.5 weeks, with 8.0% of women being diagnosed in the first, 22.2% in the second and 69.8% in the third trimester of pregnancy. There were six miscarriage (2.3%), six intrauterine device (IUD) (2.3) and 5 (2.0%) neonatal deaths, with an overall rate of perinatal death of 4.2% (11/265), thus resulting into 17 cases experiencing and 226 not experiencing composite adverse fetal outcome. Neither stillbirths nor neonatal deaths had congenital anomalies found at antenatal or postnatal evaluation. Furthermore, none of the cases experiencing IUD had signs of impending demise at arterial or venous Doppler. Neonatal deaths were all considered as prematurity-related adverse events. Of the 250 live-born neonates, one (0.4%) was found positive at RT-PCR pharyngeal swabs performed after delivery. The mother was tested positive during the third trimester of pregnancy. The newborn was asymptomatic and had negative RT-PCR test after 14 days of life. At logistic regression analysis, gestational age at diagnosis (OR: 0.85, 95% CI 0.8-0.9 per week increase; p<0.001), birthweight (OR: 1.17, 95% CI 1.09-1.12.7 per 100 g decrease; p=0.012) and maternal ventilatory support, including either need for oxygen or CPAP (OR: 4.12, 95% CI 2.3-7.9; p=0.001) were independently associated with composite adverse fetal outcome. Early gestational age at infection, maternal ventilatory supports and low birthweight are the main determinants of adverse perinatal outcomes in fetuses with maternal COVID-19 infection. Conversely, the risk of vertical transmission seems negligible

Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection.

OBJECTIVES: To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. METHODS: This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. RESULTS: In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251 (27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. CONCLUSIONS: SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. © 2020 International Society of Ultrasound in Obstetrics and Gynecology

Gravidanza ectopica istmica: report di un caso raro

Il trattamento della gravidanza ectopica con metotrexate in unica somministrazione ha riscosso molti consensi (1). Gli studi hanno dimostrato che è sicuro ed efficace in pazienti selezionati. Presentiamo un raro caso di gravidanza ectopica, istmica, trattata con successo con metotrexate

Studio retrospettivo sull’efficacia della solifenacina nella terapia dell’urge incontinence come complicanza dell’approccio transotturatorio (TOT) all’incontinenza urinaria da sforzo

Scopo del nostro studio è stato quello di valutare l’efficacia della terapia medica con antimuscarinico selettivo M3 (solifenacina succinato, 5 mg/die) nei casi di urge incontinence (UUI) iatrogena che si manifesta de novo nel corso del follow-up di chirurgia protesica con sling antincontinenza urinaria da stress (IUS) per via transotturatoria (TOT) e sulla valutazione delle sue possibili cause. Sintomi di urgenza e disuria de novo si riscontrano nel 4.7-14.8% delle TOT. Abbiamo selezionato un campione di 300 pazienti affette da IUS e sottoposte a TOT. Dopo averne seguito il decorso post-operatorio, abbiamo selezionato un campione di 44 pazienti con UUI de novo che abbiamo trattato con solifenacina succinato 5 mg/die a partire da un mese dopo l’intervento per via TOT, previa esclusione dei casi di cistite. Abbiamo ottenuto la regressione dell’urgenza-frequenza nel 100% dei casi, con un miglioramento significativo della qualità di vita

Efficacia dell’α-tocoferolo acetato (100% vitamina E) per via vaginale nella prevenzione delle erosioni dopo riparazione protesica del prolasso urogenitale

Scopo del nostro studio è stato quello di testare l’efficacia dell’a-tocoferolo acetato (100% vitamina E), in ovuli vaginali, nella prevenzione delle erosioni vaginali dopo cistopessi con mesh in polipropilene, comparandola con quella somministrata classicamente dopo gli interventi per via vaginale. Abbiamo seguito nel post-operatorio un campione di 85 pazienti di età compresa tra 55 e 74 anni (media 62.3 anni), sottoposte a cistopessi con mesh in polipropilene per la terapia del prolasso della parete vaginale anteriore (cistocele) tra gennaio 2006 e gennaio 2008, e suddiviso il campione in due bracci di trattamento, ciascuno dei quali trattato con 1 applicazione quotidiana per 3 settimane e successivamente con 2 applicazioni settimanali per le successive 20 settimane (periodo complessivo di trattamento: 23 settimane): - gruppo A, costituito da 39 pazienti trattate con estriolo in ovuli per via vaginale; - gruppo B, costituito da 46 pazienti trattate con ovuli di a-tocoferolo acetato al 100% (vitamina E). La prevalenza di erosioni vaginali nel post-operatorio è stata del 5.1% nel gruppo A (2 pazienti su 39) e del 6.5% nel gruppo B (3 pazienti su 46). L’1.1% dei casi (1 paziente su 85) ha necessitato di rimozione chirurgica parziale della mesh. La sintomatologia risulta migliorata già dopo 2 settimane in entrambi i gruppi e a 6 mesi i risultati con i 2 trattamenti sono sovrapponibili, con il 100% di pazienti soddisfatte della terapia. In conclusione, gli ovuli di a-tocoferolo acetato al 100% (vitamina E) possono essere efficacemente usati in alternativa all’estriolo nella prevenzione delle erosioni, oltre che nel trattamento topico sintomatico della vaginite atrofica

Pairwise and high-order dependencies in the cryptocurrency trading network

In this paper we analyse the effects of information flows in cryptocurrency markets. We first define a cryptocurrency trading network, i.e. the network made using cryptocurrencies as nodes and the Granger causality among their weekly log returns as links, later we analyse its evolution over time. In particular, with reference to years 2020 and 2021, we study the logarithmic US dollar price returns of the cryptocurrency trading network using both pairwise and high-order statistical dependencies, quantified by Granger causality and O-information, respectively. With reference to the former, we find that it shows peaks in correspondence of important events, like e.g., Covid-19 pandemic turbulence or occasional sudden prices rise. The corresponding network structure is rather stable, across weekly time windows in the period considered and the coins are the most influential nodes in the network. In the pairwise description of the network, stable coins seem to play a marginal role whereas, turning high-order dependencies, they appear in the highest number of synergistic information circuits, thus proving that they play a major role for high order effects. With reference to redundancy and synergy with the time evolution of the total transactions in US dollars, we find that their large volume in the first semester of 2021 seems to have triggered a transition in the cryptocurrency network toward a more complex dynamical landscape. Our results show that pairwise and high-order descriptions of complex financial systems provide complementary information for cryptocurrency analysis