抗腫瘍性トロポロン誘導体の創製と作用機序に関する研究

We image the lithospheric and upper asthenospheric structure of western continental Yemen with 24 broadband stations to evaluate the role of the Afar plume on the evolution of the continental margin and its extent eastward along the Gulf of Aden. We use teleseismic tomography to compute relative P wave velocity variations in south-western Yemen down to 300 km depth. Published receiver function analysis suggest a dramatic and localized thinning of the crust in the vicinity of the Red Sea and the Gulf of Aden, consistent with the velocity structure that we retrieve in our model. The mantle part of the model is dominated by the presence of a low-velocity anomaly in which we infer partial melting just below thick Oligocene flood basalts and recent off-axis volcanic events (from 15 Ma to present). This low-velocity anomaly could correspond to an abnormally hot mantle and could be responsible for dynamic topography and recent magmatism in western Yemen. Our new P wave velocity model beneath western Yemen suggests the young rift flank volcanoes beneath margins and on the flanks of the Red Sea rift are caused by focused small-scale diapiric upwelling from a broad region of hot mantle beneath the area. Our work shows that relatively hot mantle, along with partial melting of the mantle, can persist beneath rifted margins after breakup has occurred

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Piece-wise linear function estimation for platelet-based depth maps coding using edge detection

International audienc

Changes in fatty acids profile, monosaccharide profile and protein content during batch growth of<i>Isochrysis galbana</i>(T.iso)

International audienceTo investigate the nutritional value of the marine micro-alga Isochrysis galbana Tahitian Isochrysis strain (T.iso) as an alternative feed for aquaculture during culture age, its biochemical composition was studied under autotrophic and controlled culture conditions at different growth stages: exponential phase, early and late stationary phases and decay phase. Analysis showed that C14:0, C16:0, C16:1, C18:4 (n-3) and C22:6 (n-3) were the most abundant fatty acids in this alga at different growth stages. The highest values of monounsaturated fatty acids were recorded at the late stationary and the decay phases. However, the highest levels of polyunsaturated fatty acids were observed at the early stationary phase. At all growth stages, I. galbana (T.iso) contained arabinose, xylose, mannose, galactose and glucose. Glucose represented the main sugar, and its content per dry alga biomass weight increased with increasing age of the culture and reached about fourfold in the decay phase. The maximum protein content was also observed during this last phase

CHRONIC LINEAR ULCERATIONS OF THE INGUINO-CRURAL AND BUTTOCKS FOLDS

Vulvo-perineal Crohn's disease is a rare condition either when it is isolated or associated with digestive manifestations. In the former condition named metastatic Crohn's disease, it may constitute a diagnostic challenge and may be confused especially with other infectious or inflammatory disorders. We report a case of vulvo-perineal Crohn's disease in a 46-year-old woman. A 46-year-old woman was diagnosed with a vulvo-perineal Crohn's disease without digestive involvement. There was a chronic edema of the vulva with linear ulcerations on the inguino-crural regions and the buttocks fold, of 3 years. Treatment with metronidazole (1 g/day for 6 months) led to almost complete healing of the ulcerations with a sustained result. Physicians must be aware of the diverse manifestations and confusing presentations of vulvo-perineal Crohn's disease

First Report of in vitro Biological Agent to Biocontrol of Date Palm Stipe Rot Affected by Fusarium brachygibbosum by Using Pergularia tomentosa L., Aqueous Extract

Palm (Phoenix dactylifera L.) is a specie cultivated in Mauritania. The present study is focus on the potential of the aqueous extract of the Pergularia tomentosa L., as biological control agent against Fusarium brachygibbosum, the main agent of the date palm stipe rot disease in Mauritania. Fungal pathogen was isolated from symptomatic date palm stipe rot disease in Mauritania. The morphological characterization and the molecular identification by sequencing ITS1, ITS2 5.8 RNAr region showed homology of 98% with Fusarium brachygibbosum strain UOA/HCPF 16982 s during in vitro tests on leaves performed to verify its phytopathogenicity. the inhibitory effect of aqueous extract of Pergularia tomentosa L. on the phytopathogenic isolate (Fusarium brachygibbosum) of date palm, on mycelial growth and spore germination was observed. In fact, in vitro on PDA, mycelial growth ranged from 39.23 to 67.7 %, depending on the concentration of the aqueous extract of P. tomentosa. The aqueous extract showed a reduction of spore germination varying from 5.3 to 23.8 %. The minimum inhibitory concentrations varied from 1 to 100 mg/ml. the various extracts give high antioxidant activities exhibited by DPPH assay. Multivariant analysis by PCA plot and the heatmap were done, to evaluate the correlation between the tested parameters. These results suggest the use of Pergularia tomentosa L., extract as a biological agent to control and reduce damage caused by Fusarium brachygibbosum