The Effects of Negative Political Advertising on Young College-Educated Voters

This study examines the effectiveness of negative and positive political advertisements among voters in college. The study builds on past research exploring negative political advertising and demobilization and mobilization theories. Additionally, potential backlash against sponsoring candidates of negative policy-based attack ads is looked at as is whether those who regularly follow politics are affected differently by ads than those who do not. Fifty-three college students participated in an experiment in which they rated two candidates based on any prior knowledge and political party, assessing favorability and the likelihood of voting for each candidate. Students then watched a ten minute newscast with either a positive or negative ad sponsored by the same candidate embedded during the commercial break. They were asked again to assess their favorability and likelihood of voting for each candidate. No results were found in support of either mobilization or demobilization theories. Results did not show backlash after viewing the negative ad. The positive ad, however, proved more effective in increasing both the sponsoring candidate’s favorability and participants’ reported likelihood of voting for him. Additionally, these findings do not support past research claiming differences in effects between those who regularly follow politics and those who do not

Hedge Fund Regulation: The Amended Investment Advisers Act Does Not Protect Investors from the Problems Created by Hedge Funds

Hedge funds are a viable investment alternative for financially sophisticated investors. However, because traditional hedge funds and funds of funds are unsuitable for average investors, these investors should be restricted from making such investments. Regardless of who invests in hedge funds, advisers of these entities must be regulated to assure that they do not commit fraud. In addition to monitoring advisers, the SEC must limit hedge funds\u27 use of leverage to assure that market collapse does not occur. Part II of this Note describes the history and development of hedge funds. Part III illustrates the current problems facing the hedge fund industry. Part IV discusses hedge fund regulation prior to the Amended Investment Advisers Act of 1940. Part V analyzes the amendments to the Investment Advisers Act. Part VI discusses problems with the Amended Advisers Act. Part VII proposes solutions for more effective regulation of hedge funds. Part VIII summarizes the Note and advocates for the proposed solutions. Part IX briefly discusses the case Goldstein v. SEC which struck down the Amended Advisers Act

The Diverse Nature of Optical Emission Lines in Brightest Cluster Galaxies: IFU Observations of the Central Kiloparsecs

We present integral field spectroscopy of the nebular line emission in a sample of 9 brightest cluster galaxies (BCGs). The sample was chosen to probe both cooling flow and non-cooling flow clusters, as well as a range of cluster X-ray luminosities. The line emission morphology and velocity gradients suggest a great diversity in the properties of the line emitting gas. While some BGCs show evidence for filamentary or patchy emission (Abell 1060, Abell 1668 and MKW3s), others have extended emission (Abell 1204, Abell 2199), while still others have centrally concentrated emission (Abell 2052). We examine diagnostic line ratios to determine the dominant ionization mechanisms in each galaxy. Most of the galaxies show regions with AGN-like spectra, however for two BCGs, Abell 1060 and Abell 1204, the emission line diagnostics suggest regions which can be described by the emission from young stellar populations. The diversity of emission line properties in our sample of BCGs suggests that the emission mechanism is not universal, with different ionization processes dominating different systems. Given this diversity, there is no evidence for a clear distinction of the emission line properties between cooling flow and non-cooling flow BCGs. It is not always cooling flow BCGs which show emission (or young stellar populations), and non-cooling flow BCGs which do not.Comment: 23 pages, 23 figures, accepted for publication in MNRAS. Full resolution images are online http://web.ipac.caltech.edu/staff/louis

Elemental ratio measurements of organic compounds using aerosol mass spectrometry: characterization, improved calibration, and implications

Elemental compositions of organic aerosol (OA) particles provide useful constraints on OA sources, chemical evolution, and effects. The Aerodyne high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS) is widely used to measure OA elemental composition. This study evaluates AMS measurements of atomic oxygen-to-carbon (O : C), hydrogen-to-carbon (H : C), and organic mass-to-organic carbon (OM : OC) ratios, and of carbon oxidation state ([bar over OS][subscript C]) for a vastly expanded laboratory data set of multifunctional oxidized OA standards. For the expanded standard data set, the method introduced by Aiken et al. (2008), which uses experimentally measured ion intensities at all ions to determine elemental ratios (referred to here as "Aiken-Explicit"), reproduces known O : C and H : C ratio values within 20% (average absolute value of relative errors) and 12%, respectively. The more commonly used method, which uses empirically estimated H[subscript 2]O[superscript +] and CO[superscript +] ion intensities to avoid gas phase air interferences at these ions (referred to here as "Aiken-Ambient"), reproduces O : C and H : C of multifunctional oxidized species within 28 and 14% of known values. The values from the latter method are systematically biased low, however, with larger biases observed for alcohols and simple diacids. A detailed examination of the H[subscript 2]O[superscript +], CO[superscript +], and CO[subscript 2][superscript +] fragments in the high-resolution mass spectra of the standard compounds indicates that the Aiken-Ambient method underestimates the CO[superscript +] and especially H[subscript 2]O[superscript +] produced from many oxidized species. Combined AMS–vacuum ultraviolet (VUV) ionization measurements indicate that these ions are produced by dehydration and decarboxylation on the AMS vaporizer (usually operated at 600 °C). Thermal decomposition is observed to be efficient at vaporizer temperatures down to 200 °C. These results are used together to develop an "Improved-Ambient" elemental analysis method for AMS spectra measured in air. The Improved-Ambient method uses specific ion fragments as markers to correct for molecular functionality-dependent systematic biases and reproduces known O : C (H : C) ratios of individual oxidized standards within 28% (13%) of the known molecular values. The error in Improved-Ambient O : C (H : C) values is smaller for theoretical standard mixtures of the oxidized organic standards, which are more representative of the complex mix of species present in ambient OA. For ambient OA, the Improved-Ambient method produces O : C (H : C) values that are 27% (11%) larger than previously published Aiken-Ambient values; a corresponding increase of 9% is observed for OM : OC values. These results imply that ambient OA has a higher relative oxygen content than previously estimated. The [bar over OS][subscript C] values calculated for ambient OA by the two methods agree well, however (average relative difference of 0.06 [bar over OS][subscript C] units). This indicates that [bar over OS][subscript C] is a more robust metric of oxidation than O : C, likely since [bar over OS][subscript C] is not affected by hydration or dehydration, either in the atmosphere or during analysis.National Science Foundation (U.S.) (CHE-1012809)National Science Foundation (U.S.) (ATM-1238109

Safety of lenadogene nolparvovec gene therapy over 5 years in 189 patients with Leber hereditary optic neuropathy

Purpose: Evaluate the safety profile of lenadogene nolparvovec (Lumevoq®) in patients with Leber hereditary optic neuropathy. Design: Pooled analysis of safety data from 5 clinical studies. Methods: A total of 189 patients received single unilateral or bilateral intravitreal injections of a recombinant adeno-associated virus 2 (rAAV2/2) vector encoding the human wild-type ND4 gene. Adverse events (AEs) were collected throughout the studies, up to 5 years. Intraocular inflammation and increased intraocular pressure (IOP) were ocular AEs of special interest. Other assessments included ocular examinations, vector bio-dissemination and systemic immune responses against rAAV2/2. Results: Almost all patients (95.2%) received 9 × 1010 viral genomes and 87.8% had at least 2 years of follow-up. Most patients (75.1%) experienced at least one systemic AE, but systemic treatment-related AEs occurred in 3 patients, none was serious. Intraocular inflammation was reported in 75.6% of lenadogene nolparvovec-treated eyes. Almost all intraocular inflammations occurred in the anterior chamber (58.8%) or in the vitreous (40.3%) and was of mild (90.3%) or moderate (8.8%) intensity; most resolved with topical corticosteroids alone. All IOP increases were mild to moderate in intensity. No AE led to study discontinuation. Bio-dissemination of lenadogene nolparvovec and systemic immune response were limited. The safety profile was comparable for patients treated bilaterally and unilaterally. Conclusions: Lenadogene nolparvovec has a good overall safety profile with excellent systemic tolerability, consistent with limited bio-dissemination. The product is well tolerated, with mostly mild ocular side effects responsive to conventional ophthalmologic treatments

The Relationship of Age and Other Baseline Factors to Outcome of Initial Surgery for Intermittent Exotropia

Purpose: To determine whether age at surgery is associated with surgical outcome of intermittent exotropia (IXT) at 3 years. Design: Secondary analysis of pooled data from a randomized trial. Methods: A total of 197 children 3 to <11 years of age with basic-type IXT of 15-40 prism diopters (Δ) were randomly assigned to 1 of 2 surgical procedures for treatment of intermittent exotropia. Masked examinations were conducted every 6 months for 3 years. The primary outcome was suboptimal surgical outcome by 3 years, defined as constant or intermittent exotropia of ≥10 Δ at distance or near by simultaneous prism and cover test (SPCT); constant esotropia of ≥6 Δ at distance or near by SPCT; or decrease in near stereoacuity of ≥2 octaves, at any masked examination; or reoperation without meeting any of these criteria. Results: The cumulative probability of a suboptimal surgical outcome by 3 years was 28% (19 of 72) for children 3 to <5 years of age, compared with 50% (57 of 125) for children 5 to <11 years of age (adjusted hazard ratio = 2.05; 95% confidence interval = 1.16 to 3.60). No statistically significant associations were found between suboptimal outcome and other baseline factors (magnitude of deviation, control score, fixation preference, or near stereoacuity) (P values ≥ .20). Conclusions: This analysis suggests that in children with IXT, younger age at surgery (3 to <5 years) is associated with better surgical outcomes; however, further evidence from a randomized trial comparing immediate with delayed surgery is needed for confirmation

Applications of Partial Depth Precast Concrete Deck Panels on Horizontally Curved Steel and Concrete Bridges

0-6816Horizontally curved bridges are commonly used for direct connectors at highway intersections as well as other applications. The majority of curved bridges utilize continuous steel curved I-girder or tub girder systems. In recent years, isolated applications of spliced prestressed concrete U-beams have been successfully used for curved bridge applications in Colorado and are currently being considered for use in Texas bridges. One of the most critical construction stages from a stability perspective is placement of the wet concrete deck at which point the girders must support the full construction load of the system until the deck stiffens and acts compositely. Bridges with a curved geometry experience significant torsional forces and require a substantial amount of bracing to control deformation during construction. Bracing in the form of cross frames for steel I-girder systems, top lateral trusses for steel tub girder systems, and lid slabs for concrete U-beams are provided to improve the girder behavior. While partial depth precast concrete panels (PCPs) are commonly used as stay-in-place formwork for straight bridges, the panels are not currently permitted on horizontally curved girder systems in Texas. TxDOT would like to extend the use of PCPs to bridges with curved girders. This report focuses on the stability of PCPs that rest on polystyrene bedding strips. The project studied the behavior for PCPs with and without a positive connection to steel girders and also considered the behavior of the current TxDOT reinforcing details for PCPs with concrete U-beam systems. The experimental portion of this study consists of large-scale PCP shear tests and large-scale combined bending and torsion tests on both a twin steel I-girder system and on a single steel tub girder. The PCP shear tests were used to develop a simple and effective connection between the PCPs and the girder, as well as to empirically determine the in-plane stiffness and strength of the PCP/connection system. The large-scale girder tests were used to investigate the performance of PCPs and their connection to a system that simulates the load experienced in a realistic construction situation. Also, parametric finite element modeling of the PCPs and the curved girder systems were performed and validated with the results from the experimental tests. The finite element models were used to develop an understanding of the fundamental behavior of the steel girder systems in combination with the PCP systems. In addition to focusing on connection methods to the PCPs, guidelines were also developed for cases where the panels can be used on horizontally curved girder systems without a positive connection to the girders