Detection of bronchial preneoplastic lesions and early lung cancer with fluorescence bronchoscopy: A study about its ambulatory feasibility under local anaesthesis

Background: Autofluorescence bronchoscopy (AB) enhances the bronchoscopist's ability to diagnose bronchial preneoplastic lesions and early cancer. We undertook a study to assess its feasibility and performance under local anaesthesia on a real ambulatory mode. Methods: Thirty-four consecutive patients at very high risk for lung cancer were prospectively studied by AB under local anaesthesia, without any sedation. Lidocaine doses, time, oxygen saturation, peak expiratory flow (PEF) and the number of cough episodes were measured. Continuous assessment of the respiratory sensation was obtained with a visual analog scale. A total of 172 biopsies were performed in abnormal and normal areas. Results: The procedure was long-lasting (mean±SD: 26.6±6.0 min), required high total doses of Lidocaine (660±107 mg) without any significant side effect, and was associated with significant decreases in O2 saturation from 98.5±1.4 to 96.1±2.5% and in PEF from 380±96 to 310±78 l/min. However, the cough counts were moderate and the majority of patients reported no respiratory discomfort. 62 hyperplasia, metaplasia, dysplasia and carcinoma in situ (CIS) were detected and the relative sensitivity of AB+white-light bronchoscopy (WLB) versus WLB alone was 3.75 for intraepithelial lesions corresponding to moderate dysplasia or worse. Conclusions: AB, a procedure that increases our ability to recognize preneoplastic lesions and early lung cancer, can be performed under local anaesthesia, without systemic sedation in patients at very high risk for lung cancer. Copyright (C) 1999 Elsevier Science Ireland Ltd.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Characteristics and management of occult carcinomas of the lung: experience of autofluorescence bronchoscopy

info:eu-repo/semantics/publishe

Cancers radio-occultes (CRO) synchrones de cancers pulmonaires primitifs résécables.

4e Congrès de Pneumologie de Langue Française, Nice, Acropolis, 26-29/01/2000info:eu-repo/semantics/publishedsuppl1: 1S37 (62)

Characteristics of occult carcinomas of the lung (OCL): experience of light induced fluorescence bronchoscopy (LIFE)

ERS Annual Congress, Genève, 19-23/09/1998info:eu-repo/semantics/publishedsuppl 28 :392S (2587

Carbonic anhydrase IX antigen differentiates between preneoplastic malignant lesions in non-small cell lung carcinoma.

The MaTu interval (MN)/carbonic anhydrase (CA) IX tumour-associated antigen is a protein that is normally expressed in the gut and belongs to the carbonic anhydrase enzyme family (CA IX). It has been detected in tumour cell lines and in some solid tumours including cervical, oesophageal and clear cell renal carcinoma. This study determined MN/CA IX expression in 65 primary non-small cell lung cancer resected with curative intent and in 38 bronchial preneoplastic lesions, carcinoma in situ or microinvasive carcinoma as well as in normal bronchial tissue. The presence of MN/CA IX was detected using immunohistochemistry and Western blot analysis, whenever frozen material was available. Immunostaining was positive in 52/65 (80%) of the tumour samples. The staining was more often focal than diffuse. The percentage of stained cells in positive tumours was highly variable, ranging 1-85%. The pattern of immunostaining was predominantly cytoplasmic with a membranous reinforcement (87%). The intensity was mainly strong (69%). The presence of the protein in the tumour was confirmed by Western blot analysis in the eight samples tested. All the morphologically normal epithelia, except in close vicinity of tumours in some cases, as well as the preneoplastic bronchial lesions (basal cell hyperplasia, metaplasia and dysplasia) were immunonegative for MN/CA IX expression. In contrast, carcinoma in situ and microinvasive epithelioma showed the presence of MN-immunopositive tumoural cells in 5/7 and 4/5 of the samples, respectively. These data suggest that MN/CA IX is a useful marker for the differentiation between preneoplastic lesions and bronchial non-small cell lung cancer in the lung.Comparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe

Synchronous occult lung carcinoma (OLC) in patients with resectable primary lung cancer

ERS Annual Congress, Madrid, Espagneinfo:eu-repo/semantics/publishedsuppl 30,248s (1689

Correlation between histological examination of bronchi from resected lung specimens and preoperative evaluation with fluorescence bronchoscopy (FB)

ERS Annual Congress, Madrid, Espagneinfo:eu-repo/semantics/publishedsuppl 30,125s-126s (P863

Therapeutic use of granulocyte and granulocyte-macrophage colony-stimulating factors in febrile neutropenic cancer patients: A systematic review of the literature with meta-analysis

SCOPUS: re.jinfo:eu-repo/semantics/publishe