The Epidemics of Injecting Drug Use and Blood-Borne Disease: A Public Health Perspective

In this article, the author first examines the mechanism by which blood-borne disease is transmitted through sharing of injection equipment. Thereafter, he presents a public health strategy for reducing multi-person use of contaminated injection equipment. This strategy includes: repealing or modifying current laws and regulations making possession and distribution of sterile injection equipment a criminal offense; implementing syringe exchange programs to expand access to new syringes for users of injection drugs; and counseling, education, and treatment targeted to injecting drug users (IDUs), including those in the prison and health care system. The objective of a public health approach is not to encourage or enable IDUs to obtain and use drugs; public health strategies actively seek to reduce drug use due to its profound adverse effects on physical and mental health. Rather, the public health approach seeks to substantially improve health outcomes for IDUs who cannot or will not stop using drugs

Evaluating and optimizing computational protein design force fields using fixed composition-based negative design

An accurate force field is essential to computational protein design and protein fold prediction studies. Proper force field tuning is problematic, however, due in part to the incomplete modeling of the unfolded state. Here, we evaluate and optimize a protein design force field by constraining the amino acid composition of the designed sequences to that of a well behaved model protein. According to the random energy model, unfolded state energies are dependent only on amino acid composition and not the specific arrangement of amino acids. Therefore, energy discrepancies between computational predictions and experimental results, for sequences of identical composition, can be directly attributed to flaws in the force field's ability to properly account for folded state sequence energies. This aspect of fixed composition design allows for force field optimization by focusing solely on the interactions in the folded state. Several rounds of fixed composition optimization of the 56-residue β1 domain of protein G yielded force field parameters with significantly greater predictive power: Optimized sequences exhibited higher wild-type sequence identity in critical regions of the structure, and the wild-type sequence showed an improved Z-score. Experimental studies revealed a designed 24-fold mutant to be stably folded with a melting temperature similar to that of the wild-type protein. Sequence designs using engrailed homeodomain as a scaffold produced similar results, suggesting the tuned force field parameters were not specific to protein G

Apocalypse - 2002

Contributers include: Danny Byzantine, Corey Emory, Stone Abang, James Nguyen, John Desjarlais, Michael L. Johnson, John Grey, Eric Shapiro, Melissa K. Simmons, Dennis Van Wey, Daniel Green, Jenene O. Ravesloot, Jane McClellan, Diana Smith, Corey Emory, Chris-Marie Ware, Mike Catalano, B.Z. Niditchhttps://neiudc.neiu.edu/apocalypse/1005/thumbnail.jp

1972 Statistics

1972 Men\u27s Cross Country Statistics, George Fox College

Exploring a shared history : Indian-White relations between Fishing Lake First Nation and Wadena, 1882-2002

A great deal of literature exists that documents the nature and development of relations between Native and Newcomer groups in what is today the Eastern and Maritime regions of Canada. By comparison, however, studies which examine interaction between these two groups in Canada's prairie region are considerably lacking. Although a sufficient amount has been written about prairie Indian peoples and their experiences with government officials and policy, relatively little is known about relations between Indian reserve communities and neighbouring immigrant communities, particularly during the early years of settlement. A survey of existing sources suggests that during this time Indian people were simply settled on reserves and immigrant towns grew up around them, each, it seems, operating in complete isolation from the other.This thesis aims to fill this gap in the historical literature by attempting to draw out the essence of the integrated and intertwined elements of the history shared by two prairie communities. The basic aim of this study is to trace the nature and development of relations between Fishing Lake First Nation and Wadena, located in the east central portion of Saskatchewan, from the 1880s to the present. Exploring a Shared History seeks to provide a more thorough understanding of and broader perspective on an important, yet much-neglected, facet of the region's history