Baseline geochemistry of Devonian low-grade metasedimentary rocks in Cornwall: preliminary data and environmental significance.

Geochemical baseline data provide information on the state of the environment before modification by mining and other anthropogenic activities. A summary of the analyses of 41 elements on 100 samples from Devonian metasedimentary rocks away from areas of mineralization and granite intrusions in Cornwall are presented. The data show a remarkable consistency. Differences in major elements can be related largely to changes in mineral proportion expected from grain size variations within the sedimentary rocks. The trace element data indicate that similar types of sediment accumulated in the Gramscatho, Looe and Trevone basins and that subsequent metamorphism has not significantly re-distributed elements. Compared with an average UK Lower Palaeozoic shale and the North American Shale Composite, the Devonian metasedimentary rocks of Cornwall appear to be marginally depleted in many trace elements. Values for As, Ni and Cr frequently exceed published soil guideline values, especially in mudstones, which brings into question the issue of the identification of land, which is considered to be polluted

Gene-flow between populations of cotton bollworm Helicoverpa armigera (Lepidoptera: Noctuidae) is highly variable between years

Both large and small scale migrations of Helicoverpa armigera Hübner in Australia were investigated using AMOVA analysis and genetic assignment tests. Five microsatellite loci were screened across 3142 individuals from 16 localities in eight major cotton and grain growing regions within Australia, over a 38-month period (November 1999 to January 2003). From November 1999 to March 2001 relatively low levels of migration were characterized between growing regions. Substantially higher than average gene-flow rates and limited differentiation between cropping regions characterized the period from April 2001 to March 2002. A reduced migration rate in the year from April 2002 to March 2003 resulted in significant genetic structuring between cropping regions. This differentiation was established within two or three generations. Genetic drift alone is unlikely to drive genetic differentiation over such a small number of generations, unless it is accompanied by extreme bottlenecks and/or selection. Helicoverpa armigera in Australia demonstrated isolation by distance, so immigration into cropping regions is more likely to come from nearby regions than from afar. This effect was most pronounced in years with limited migration. However, there is evidence of long distance dispersal events in periods of high migration (April 2001–March 2002). The implications of highly variable migration patterns for resistance management are considered.K.D. Scott, K.S. Wilkinson, N. Lawrence, C.L. Lange, L.J. Scott, M.A. Merritt, A.J. Lowe and G.C Graha

The curious nonexistence of Gaussian 2-designs

2-designs -- ensembles of quantum pure states whose 2nd moments equal those of the uniform Haar ensemble -- are optimal solutions for several tasks in quantum information science, especially state and process tomography. We show that Gaussian states cannot form a 2-design for the continuous-variable (quantum optical) Hilbert space L2(R). This is surprising because the affine symplectic group HWSp (the natural symmetry group of Gaussian states) is irreducible on the symmetric subspace of two copies. In finite dimensional Hilbert spaces, irreducibility guarantees that HWSp-covariant ensembles (such as mutually unbiased bases in prime dimensions) are always 2-designs. This property is violated by continuous variables, for a subtle reason: the (well-defined) HWSp-invariant ensemble of Gaussian states does not have an average state because the averaging integral does not converge. In fact, no Gaussian ensemble is even close (in a precise sense) to being a 2-design. This surprising difference between discrete and continuous quantum mechanics has important implications for optical state and process tomography.Comment: 9 pages, no pretty figures (sorry!

Case report of whole genome sequencing in the XY female: identification of a novel SRY mutation and revision of a misdiagnosis of androgen insensitivity syndrome

Background: The 46,XY female is characterised by a male karyotype and female phenotype arising due to any interruption in the sexual development pathways in utero. The cause is usually genetic and various genes are implicated. Case presentation: Herein we describe a 46,XY woman who was first diagnosed with androgen insensitivity syndrome (testicular feminisation) at 18 years; however, this was later questioned due to the presence of intact Müllerian structures. The clinical phenotype suggested several susceptibility genes including SRY, DHH, NR5A1, NR0B1, AR, AMH, and AMHR2. To study candidate genes simultaneously, we performed whole genome sequencing. This revealed a novel and likely pathogenic missense variant (p.Arg130Pro, c.389G>C) in SRY, one of the major genes implicated in complete gonadal dysgenesis, hence securing this condition over androgen insensitivity syndrome as the cause of the patient’s disorder of sexual development. Conclusion: This case highlights the emerging clinical utility of whole genome sequencing as a tool in differentiating disorders of sexual development.Sunita M. C. De Sousa, Karin S. Kassahn, Liam C. McIntyre, Chan-Eng Chong, Hamish S. Scott and David J. Torp

A two-armed bandit based scheme for accelerated decentralized learning

The two-armed bandit problem is a classical optimization problem where a decision maker sequentially pulls one of two arms attached to a gambling machine, with each pull resulting in a random reward. The reward distributions are unknown, and thus, one must balance between exploiting existing knowledge about the arms, and obtaining new information. Bandit problems are particularly fascinating because a large class of real world problems, including routing, QoS control, game playing, and resource allocation, can be solved in a decentralized manner when modeled as a system of interacting gambling machines. Although computationally intractable in many cases, Bayesian methods provide a standard for optimal decision making. This paper proposes a novel scheme for decentralized decision making based on the Goore Game in which each decision maker is inherently Bayesian in nature, yet avoids computational intractability by relying simply on updating the hyper parameters of sibling conjugate priors, and on random sampling from these posteriors. We further report theoretical results on the variance of the random rewards experienced by each individual decision maker. Based on these theoretical results, each decision maker is able to accelerate its own learning by taking advantage of the increasingly more reliable feedback that is obtained as exploration gradually turns into exploitation in bandit problem based learning. Extensive experiments demonstrate that the accelerated learning allows us to combine the benefits of conservative learning, which is high accuracy, with the benefits of hurried learning, which is fast convergence. In this manner, our scheme outperforms recently proposed Goore Game solution schemes, where one has to trade off accuracy with speed. We thus believe that our methodology opens avenues for improved performance in a number of applications of bandit based decentralized decision making

Economic analysis of ethanol production from switchgrass using hybrid thermal/biological processing

The economics of ethanol production from switchgrass using Waterloo fast pyrolysis with a fermentation step is investigated. Standard chemical engineering methods are used to estimate capital investment and operating costs. Order of magnitude method is employed for preliminary approximation of capital investment. The azeotropic ethanol production capacity used in this case study is 189 million liters/year (50 million gallons/year). All cost figures are updated to 1997 US $. Total capital investment is estimated to be$142 million, while the annual operating cost is about $118 million with an ethanol selling price of$0.62/l ($2.35/gal). This compares to$0.58/l ($2.20/gal) for ethanol from popular wood as determined in a previous study of the Waterloo fast pyrolysis process. Conservation of energy, especially, in the separation and purification steps, and generation of steam from lignin to meet energy requirements are evaluated in terms of energy saving costs. Additional steam has to be purchased, at$0.30 million/year, in order to meet the heat energy requirement of the process. Sensitivity analyses of feedstock cost and yield of sugar fermentation on the selling price of ethanol show that feedstock cost is positively related to ethanol selling price, while the yield has a negative relationship with selling price

The role of aerodynamic forces in a mathematical model for suspension bridges

In a fish-bone model for suspension bridges studied by us in a previous paper we introduce linear aerodynamic forces. We numerically analyze the role of these forces and we theoretically show that they do not influence the onset of torsional oscillations. This suggests a new explanation for the origin of instability in suspension bridges: it is a combined interaction between structural nonlinearity and aerodynamics and it follows a precise pattern. This gives an answer to a long-standing question about the origin of torsional instability in suspension bridges

Evolution of circular, non-equatorial orbits of Kerr black holes due to gravitational-wave emission: II. Inspiral trajectories and gravitational waveforms

The inspiral of a ``small'' ($\mu \sim 1-100 M_\odot$) compact body into a ``large'' ($M \sim 10^{5-7} M_\odot$) black hole is a key source of gravitational radiation for the space-based gravitational-wave observatory LISA. The waves from such inspirals will probe the extreme strong-field nature of the Kerr metric. In this paper, I investigate the properties of a restricted family of such inspirals (the inspiral of circular, inclined orbits) with an eye toward understanding observable properties of the gravitational waves that they generate. Using results previously presented to calculate the effects of radiation reaction, I assemble the inspiral trajectories (assuming that radiation reacts adiabatically, so that over short timescales the trajectory is approximately geodesic) and calculate the wave generated as the compact body spirals in. I do this analysis for several black hole spins, sampling a range that should be indicative of what spins we will encounter in nature. The spin has a very strong impact on the waveform. In particular, when the hole rotates very rapidly, tidal coupling between the inspiraling body and the event horizon has a very strong influence on the inspiral time scale, which in turn has a big impact on the gravitational wave phasing. The gravitational waves themselves are very usefully described as ``multi-voice chirps'': the wave is a sum of ``voices'', each corresponding to a different harmonic of the fundamental orbital frequencies. Each voice has a rather simple phase evolution. Searching for extreme mass ratio inspirals voice-by-voice may be more effective than searching for the summed waveform all at once.Comment: 15 pages, 11 figures, accepted for publication in PRD. This version incorporates referee's comments, and is much less verbos

Perturbative Prepotential and Monodromies in N=2 Heterotic Superstring

We discuss the prepotential describing the effective field theory of N=2 heterotic superstring models. At the one loop-level the prepotential develops logarithmic singularities due to the appearance of charged massless states at particular surfaces in the moduli space of vector multiplets. These singularities modify the classical duality symmetry group which now becomes a representation of the fundamental group of the moduli space minus the singular surfaces. For the simplest two-moduli case, this fundamental group turns out to be a certain braid group and we determine the resulting full duality transformations of the prepotential, which are exact in perturbation theory.Comment: 39 pages, LaTeX, no figures; section 6 expanded to include explicit construction of the monodromy group in a (4,0) orbifold exampl