Population Bulletin, VOL. 75, NO. 1

This is an overview of important demographic processes including fertility, mortality, and migration, and their effects on population growth, decline, and composition. The authors describe changes in the geographic distribution of the world’s population, historical patterns of global

THE EFFECT OF MEDROXYPROGESTERONE ACETATE ON PREMATURE LABOR IN THE SHEEP

The ability of medroxyprogesterone acetate to premature delivery delay was investigated in nine chronically catheterized pregnant sheep (125 to 130 days' gestation). Catheters were placed for measurement of intrauterine pressure and uterine vein concentrations of progesterone,17 beta-estradiol,and 15-keto-13,14-dihydroxyprostaglandin F2a. Premature parturition was induced in all animals by infusion of dexamethasone (1 mg/24 hours) to the fetus. Three ewes served as controls,three ewes received oral medroxyprogesterone acetate (5 mg/kg/day) 48 hours prior to the start of and during dexamethasone (early medroxyprogesterone acetate),and the remaining three animals received oral medroxyprogesterone acetate 12 hours after the onset of dexamethasone infusion (late medroxyprogesterone acetate). The lengths of time from dexamethasone until the onset of labor and from dexamethasone until delivery were compared,and were significantly longer for each group compared to control times. Of all endocrine events analyzed,the fall in plasma progesterone was the most consistent in all groups,showing that animals with rapid falls in progesterone levels (control group) tended to deliver earlier. These results demonstrate that medroxyprogesterone acetate can delay premature parturition in the sheep. Also medroxyprogesterone acetate appears to delay the endocrinologic events that normally occur at this tim

Assessing the role of program suspend operation in 3d nand flash based solid state drives

3D NAND Flash is the preferred storage medium for dense mass storage applications, including Solid State Drives and multimedia cards. Improving the latency of these systems is a mandatory task to narrow the gap between computing elements, such as CPUs and GPUs, and the storage environment. To this extent, relatively time-consuming operations in the storage media, such as data programming and data erasing, need to be prioritized and be potentially suspendable by shorter operations, like data reading, in order to improve the overall system quality of service. However, such benefits are strongly dependent on the storage characteristics and on the timing of the single operations. In this work, we investigate, through an extensive characterization, the impacts of suspending the data programming operation in a 3D NAND Flash device. System-level simulations proved that such operations must be carefully characterized before exercising them on Solid State Drives to eventually understand the performance benefits introduced and to disclose all the potential shortcomings

A nove heterozygous SOX2 mutation causing anophtalmia/microphtalmia with genital anomalies

Anophthalmia/microphthalmia is a rare developmental craniofacial defect, which recognizes a wide range of causes, including chromosomal abnormalities, single-gene mutations as well as environmental factors. Heterozygous mutations in the SOX2 gene are the most common monogenic form of anophthalmia/microphthalmia, as they are reported in up to 10-15% cases. Here, we describe a sporadic patient showing bilateral anophthalmia/microphthalmia and micropenis caused by a novel mutation (c.59_60insGG) in the SOX2 gene. Morphological and endocrinological evaluations excluded any anomaly of the hypothalamus-pituitary axis. Our finding supports the hypothesis that SOX2 is particularly prone to slipped-strand mispairing, which results in a high frequency of point deletions/insertions