7 research outputs found
Randomized Controlled Trial of Fish Oil and Montelukast and Their Combination on Airway Inflammation and Hyperpnea-Induced Bronchoconstriction
- Author
- A Sandrini
- Alyce D. Fly
- B Dahlen
- CR Beasley
- DS Pearlman
- F Grimminger
- FC Thien
- G Philip
- Gregory S. Montgomery
- H Kanazawa
- I Horvath
- J Reisman
- JA Leff
- JD Brannan
- JF Hunt
- JM Drazen
- Joel M. Stager
- JP Finnerty
- JP Parsons
- JW Weiss
- JY Lee
- KW Rundell
- KW Rundell
- L Ghiro
- Louise A. Turner
- M Duong
- M Scollo
- NE Brummel
- P Kippelen
- P Montuschi
- PC Calder
- PC Calder
- PM O'Byrne
- PM O'Byrne
- PM O'Byrne
- R Accordino
- R Gorjao
- R Koczulla
- R Schubert
- RE Martin
- Rory Edward Morty
- S O'Sullivan
- S O'Sullivan
- Sandra Tecklenburg-Lund
- SD Anderson
- SD Anderson
- SE Dahlen
- SE Dahlen
- SL Tecklenburg
- SM ElHalawani
- SM Weldon
- ST Holgate
- TD Mickleborough
- TD Mickleborough
- TD Mickleborough
- TD Mickleborough
- TD Mickleborough
- TH Lee
- Timothy D. Mickleborough
- TK Lund
- TS Hallstrand
- TS Hallstrand
- TS Hallstrand
- WC Willett
- Publication venue
- Public Library of Science
- Publication date
- 01/10/2010
- Field of study
Both fish oil and montelukast have been shown to reduce the severity of exercise-induced bronchoconstriction (EIB). The purpose of this study was to compare the effects of fish oil and montelukast, alone and in combination, on airway inflammation and bronchoconstriction induced by eucapnic voluntary hyperpnea (EVH) in asthmatics.
In this model of EIB, twenty asthmatic subjects with documented hyperpnea-induced bronchoconstriction (HIB) entered a randomized double-blind trial. All subjects entered on their usual diet (pre-treatment, n = 20) and then were randomly assigned to receive either one active 10 mg montelukast tablet and 10 placebo fish oil capsules (n = 10) or one placebo montelukast tablet and 10 active fish oil capsules totaling 3.2 g EPA and 2.0 g DHA (n = 10) taken daily for 3-wk. Thereafter, all subjects (combination treatment; n = 20) underwent another 3-wk treatment period consisting of a 10 mg active montelukast tablet or 10 active fish oil capsules taken daily.
While HIB was significantly inhibited (p0.017) between treatment groups; percent fall in forced expiratory volume in 1-sec was −18.4±2.1%, −9.3±2.8%, −11.6±2.8% and −10.8±1.7% on usual diet (pre-treatment), fish oil, montelukast and combination treatment respectively. All three treatments were associated with a significant reduction (p0.017) in these biomarkers between treatments.
While fish oil and montelukast are both effective in attenuating airway inflammation and HIB, combining fish oil with montelukast did not confer a greater protective effect than either intervention alone. Fish oil supplementation should be considered as an alternative treatment for EIB
A Varying Coefficient Model to Measure the Effectiveness of Mass Media Anti-Smoking Campaigns in Generating Calls to a Quitline
- Author
- Publication venue
- 'Japan Epidemiological Association'
- Publication date
- 01/01/2010
- Field of study
Clinical Experience with New Antiepileptic Drugs: Antiepileptic Drugs in Europe
- Author
- Bonduelle M
- Bourgeois BFD
- Buchthal F
- Buchthal F
- Callaghan N
- Canger R.
- Carraz G
- Cereghino JJ
- Gamstorp I.
- Gastaut H
- Gastaut H.
- Gram L.
- Hauptmann A.
- Heller AJ
- International glossary of antiepileptic drugs
- Jallon P
- Janz D.
- Larkin JG
- Loiseau P
- Lorge M.
- Mattson RH
- Mattson RH
- Merritt HH
- Mikkelsen B
- Parsonage M.
- Passouant P
- Perucca E.
- Reynolds EH
- Richards RK
- Richens A
- Scollo-Lavizzari G.
- Shorvon S.
- Shorvon SD
- Tassinari CA
- Wilder BJ
- Zimmerman FT
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Discontinuation of Clonazepam After Long-Term Treatment
- Author
- Aarli JA.
- Bamett AM.
- Bang F.
- Bensch J.
- Bergamini L.
- Boudin G.
- Browne TR.
- Chandra B.
- D'Onghia AC
- Dreifuss FE
- Dumermuth G.
- Fazio C.
- Froscher W.
- Gamstorp I.
- Gastaut H.
- Gastaut H.
- Groh Ch
- Hanson RA
- Hooshmand H.
- Huang CY
- Kick H.
- Knop HJ
- Kruse R.
- Lund M.
- Martin D.
- Masland RL
- Mikkelsen B.
- Nanda RN
- Negrin P.
- Nogen AG.
- O'Donohoe NV
- Pinder RM
- Rett A.
- Rossi GF
- Roussounis SH
- Schmidt D.
- Schmidt D.
- Scollo-Lavizzari G.
- Shorvon SD
- Vassella F.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Open Trials with Valproate in Epilepsy
- Author
- Bachman DS.
- Barnes SE
- Beaudouin JL
- Beaumanoir A.
- Beran RG
- Bergamini L.
- Bruni J.
- Burton BS.
- Carraz G.
- Chayasirisobhon S.
- Covanis A.
- Covanis A.
- De Biolley D.
- Doose H.
- Dravet C.
- Dulac O.
- Dumon-Radermecker M.
- Feuerstein J.
- Feuerstein J.
- Feuerstein J.
- Forster C.
- Gamstorp I.
- Gastaut H.
- Genio R.
- Grant RHE
- Haigh D.
- Harwood G.
- Hassan MN
- Henriksen O.
- Jeavons PM
- Jeavons PM
- Jeavons PM
- Jeavons PM.
- Kakegawa N.
- Keene DL
- Kerfriden P.
- Kleijn E.
- Kugler J.
- Lairy CG.
- Lugaresi E.
- Mairlot FE.
- Mairlot FE.
- Meinardi H.
- Meinardi H.
- Meunier H.
- Olive D.
- Pavone L.
- Pillen E.
- Pinder RM
- Price DJ.
- Reynolds EH
- Richens A.
- Roger J.
- Roger J.
- Roger J.
- Salzarulo P.
- Schafer J.
- Schmidt D.
- Scollo-Lavizzari G.
- Simon D.
- Suzuki M.
- Timpany M.
- Vajda F.
- Vakil SD
- Viani F.
- Vining EP
- Wilder BJ
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Global impact of the COVID-19 pandemic on stroke volumes and cerebrovascular events: one-year follow-up.
- Author
- Abdalkader M
- Acampa M
- Aguiar de Sousa D
- Alexiev F
- Alpay K
- Barrientos Guerra JD
- Bedekovic MR
- Bernady P
- Bohmann FO
- Bonnet T
- Boskamp S
- Bralic M
- Budincevic H
- Cabal M
- Campbell BCV
- Casenave P
- Catanese L
- Charidimou A
- Chen HS
- Chen Y
- Christensen H
- Conforto AB
- Cora EA
- Corredor-Quintero AB
- Czlonkowska A
- Dan M
- de Oliveira Neves L
- De Raedt S
- Demeestere J
- Drenck N
- Enzinger C
- et al.
- Farhoudi M
- Faucheux JM
- Fibrich P
- Gattringer T
- Gentric JC
- Ghoreishi A
- Goyal M
- Goyal N
- Haussen DC
- Herzig R
- Hidalgo RCT
- Hill MD
- Hlaváčová H
- Hlinovsky D
- Hokmabadi ES
- Hrabanovska E
- Huded V
- Huo X
- Inoa V
- Iversen HK
- Jurak L
- Kadlcikova J
- Kalmanovich SA
- Kalpachki R
- Karapanayiotides T
- Kargiotis O
- Karpowicz I
- Kelly ME
- Khosravani H
- Klecka L
- Klein P
- Koutroulou I
- Kovar M
- Krishna Pramana NA
- Kristoffersen ES
- Lameirinhas da Silva I
- Lara-Sarabia OE
- Lauer D
- Lavoie P
- Lemmens R
- Lereis VP
- Lesaine E
- Ligot N
- Lo HC
- Loochtan AI
- Ma A
- Magro E
- Mansour OY
- Martins RT
- Martins RT
- Mbroh J
- Menon B
- Miao Z
- Mikulik R
- Mohammaden M
- Mora Cuervo DL
- Nagel S
- Nagendra S
- Neumann J
- Nguyen TN
- Nolte C
- Palaiodimou L
- Palouskova H
- Parsons MW
- Peeling L
- Pikula A
- Poli S
- Prajapati C
- Qureshi MM
- Rahman A
- Raya TA
- Rebello LC
- Reiner P
- Reiser M
- Rekova P
- Ringleb PA
- Rivera R
- Rohan V
- Ronen L
- Rosenkranz M
- Rouanet F
- Sabben C
- Sabetay SI
- Sakelarova T
- Sani AF
- Santiago IB
- Sathya A
- Scollo SD
- Sedova P
- Siegler JE
- Singhal S
- Skoda O
- Slater LA
- Sobh K
- Sobotková L
- Sramek M
- Strbian D
- Sylaja PN
- Škorňa M
- Tenora D
- Thomalla G
- Thomas JO
- Truelsen TC
- Tsivgoulis G
- Uchino K
- Vanacker P
- Vandervorst F
- Vanguru HR
- Wienecke T
- Yaghi S
- Yamagami H
- Yang S
- Ylikotila P
- Zakova L
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background and objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020).
Methods: We conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases.
Results: There were 148,895 stroke admissions in the 1 year immediately before compared with 138,453 admissions during the 1-year pandemic, representing a 7% decline (95% CI [95% CI 7.1-6.9]; p < 0.0001). ICH volumes declined from 29,585 to 28,156 (4.8% [5.1-4.6]; p < 0.0001) and IVT volume from 24,584 to 23,077 (6.1% [6.4-5.8]; p < 0.0001). Larger declines were observed at high-volume compared with low-volume centers (all p < 0.0001). There was no significant change in mechanical thrombectomy volumes (0.7% [0.6-0.9]; p = 0.49). Stroke was diagnosed in 1.3% [1.31-1.38] of 406,792 COVID-19 hospitalizations. SARS-CoV-2 infection was present in 2.9% ([2.82-2.97], 5,656/195,539) of all stroke hospitalizations.
Discussion: There was a global decline and shift to lower-volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared with the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year
A second update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar MS
- Abdel-Aziz M
- Abdelrazik M
- Abdullah MS
- Abe R
- Abe S
- Abel L
- Abel L
- Abernathy C
- Abraham R
- Abraheem A
- Abu Alragheb BO
- Abulail JA
- Acklery A
- Acosta-Herrera M
- Adachi T
- Adachi Y
- Adam R
- Adams C
- Adams K
- Adams N
- Adanini O
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agravante K
- Agrawal A
- Agrawal S
- Aguado JM
- Aguilar C
- Aguilar SEV
- Aguilar-Salinas CA
- Aguilera-Albesa S
- Agüero D
- Ahmad HF
- Ahmad N
- Ahmadhaider N
- Ahmed A
- Ahmed C
- Ahram M
- Ai M
- Ain Q
- Aitkin E
- Akeroyd L
- Akhtar MN
- Akinkugbe O
- Al-Ani A
- Al-Ja’afreh MM
- Al-Kadash A
- Al-Kasasbeh MM
- Al-Moasseb H
- Al-Muftah W
- Al-Sarraj Y
- Alamer LM
- Alasdair F
- Alawneh FM
- Alawneh LM
- Albaiceta GM
- Albano G
- Albillos A
- Albrecht W
- Aldridge J
- Alexander P
- Alfonso J
- Alhousani TN
- Ali A
- Ali HH
- Ali IAM
- Ali S
- Aliberti S
- ALjalamdeh M
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen M
- Allen S
- Allen U
- Allibone S
- Allison KS
- Allouzy SK
- Ally SM
- Almadana V
- Almaden-Boyle C
- Almoguera B
- Alpuche-Aranda C
- AlRawashdeh TJ
- Alsafadi DB
- Alshaer W
- Alsoub FS
- Altabaibeh A
- Alvarez N
- Alvaro A
- Alzuraiqi MR
- Amamio M
- Aman NF
- Amin V
- Amiya S
- Ampuero J
- Anan R
- Anastasescu E
- Andersen S
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Ando A
- Andrade V
- Andreou P
- Andreu-Bernabeu Á
- Andrew A
- Andrew B
- Andrew G
- Andrews J
- Andrews S
- Andrews SJ
- Angelini C
- Ansari AI
- Antcliffe D
- Antoine P
- Antony S
- Anumakonda V
- Anwer M
- Anzai T
- Apetri E
- Aquino M
- Aquino-Gálvez A
- Arai D
- Arakelyan A
- Arana-Arri E
- Arana-Arri E
- Arango C
- Aravindan L
- Arbane G
- Archer K
- Arden T
- Arias SS
- Arif S
- Arimura K
- Armistead J
- Armstrong D
- Armstrong J
- Armstrong L
- Armstrong R
- Arning N
- Arnoldo S
- Arnott A
- Arora J
- Arora M
- Arranz MJ
- Arranz MJ
- Arribas-Rodriguez E
- Artiga M-J
- Arumugam P
- Asakura T
- Asano K
- Aschard H
- Ashby K
- Ashok SR
- Ashraf S
- Ashton L
- Asimakopoulos A
- Aslibekyan S
- Asselta R
- Astin-Chamberlain R
- Atayeva N
- Athanasiou L
- Atkinson EG
- Attwood B
- Atwal I
- Augustin M
- Auld D
- Auld F
- Austin K
- Austin P
- Auton A
- Avetyan D
- Awano N
- Awasthi S
- Ayers A
- Ayo NI
- Ayuso C
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- Azuure C
- Azzolini E
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- Badal B
- Badalamenti S
- Baddeley A
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- Bafitis V
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- Baikady RR
- Bailey L
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- Baines D
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- Baker M
- Bakthavatsalam D
- Balaconis MK
- Baldini M
- Balla D
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- Bamford A
- Bamford A
- Bamford P
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- Banales JM
- Banasik K
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- Bancroft H
- Band G
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- Bani younis FM
- Bano S
- Baptista D
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- Cejudo TG
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- Chang TS
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- Cheatley PL
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- Chiba S
- Chihara Y
- Chikowore P
- Childs D
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- Choudhr O
- Choudhury Y
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- Chung M
- Churchhouse C
- Chwialkowska K
- Chwiałkowska K
- Chávez-Alderete J
- Chávez-Manzanera E
- Ciccarelli M
- Ciesek S
- Cinquina Z
- Cirulli ET
- Citerio G
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- Clamp S
- Clapham M
- Clarey E
- Claridge H
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- Clausen M
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- Clement I
- Clements S
- Coates C
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- Coghlan P
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- Colbert SMC
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- Tanate A
- Tanck A
- Taneski F
- Tani M
- Tanigawa Y
- Tanino Y
- Taniyama D
- Tanudjaja F
- Taracido-Fernandez JC
- Tardif N
- Tariq A
- Tateishi T
- Tateno H
- Tatham K
- Tauekelova A
- Tauro S
- Tavares S
- Taylor B
- Taylor C
- Taylor J
- Taylor J-A
- Taylor K
- Taylor M
- Taylor M
- Tebbutt J
- Tedstone R
- Teles A
- Templeton M
- Tench H
- Tenesa A
- Tenorio-Castaño JA
- Tentorio P
- Teoh PC
- Teper A
- Terai H
- Terranova L
- Tetla D
- Teumer A
- Texeira J
- Thanasi M
- Thani AA
- Thankachen M
- Thibeault C
- Thirlwall Y
- Thirumaran M
- Thiruvahindrapuram B
- Thomas A
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- Thomas V
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- Thompson G
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- Thompson WK
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- Thornton L
- Thorpe C
- Thrasyvoulou L
- Thrush J
- Thwaites V
- Tibke C
- Tiembe N
- Tierney C
- Tilbey S
- Tiller H
- Tilney E
- Timens W
- Timlick E
- Timpson NJ
- Ting L
- Tiongson G
- Tivenan H
- Toapanta D
- Tobar-Calfucoy EA
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- Tohda S
- Tokunaga K
- Tolson M
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- Tomasi M
- Tomkova G
- Tomlinson J
- Tomono K
- Tonby K
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- Toohie J
- Torky MS
- Torrents D
- Torres-Espíndola LM
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- Toxqui-Merchant LE
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- Trankiem A
- Tranter H
- Travers J
- Tregouet D-A
- Trembath RC
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- Treus E
- Tridente A
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- Trotman S
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- Truman N
- Trumper E
- Tse SM
- Tsechoeva T
- Tselios C
- Tsilidis K
- Tsinaslanidis G
- Tsourlos S
- Tsuchida T
- Tsuo K
- Tubiana S
- Tucci A
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- Tutt G
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- Tzoulaki I
- Téllez L
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- Uitterlinden AG
- Ullum H
- Umeda A
- Upadhyay KJ
- Upton J
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- Vadgama N
- Vadla MS
- Vaida M
- Valdeavella K
- Valdés PA
- Valencia-Ramos J
- Valenti L
- Valenzuela-Jorquera H
- Vallerga CL
- Valsecchi MG
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- Van Heel DA
- Van Heel DA
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- Vandernoot I
- Varghese M
- Vasilevska-Ristovska J
- Vassell K
- Vedage D
- Veerapen K
- Vega J
- Vehreschild MJGT
- Velasco DG
- Velázquez-Cruz R
- Venkatesh H
- Verdugo RA
- Verdugo RA
- Vergasova E
- Verlander M
- Vertue M
- Verula J
- Vigueras-Hernández A
- Vigurs C
- Villa A
- Villalonga JM
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- Virgilio E
- Virginia M-RA
- Vitart V
- Vizcaychipi M
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- Von Hohenstaufen Puoti KA
- Voza A
- Vuylsteke A
- Várnai R
- Vázquez-Pérez JA
- Wacker EM
- Wackett T
- Wadams B
- Waddell G
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- Wagner R
- Wagstaff V
- Waite AAC
- Wakabayashi A
- Wakahara K
- Wakefield P
- Wakinshaw F
- Waldron J
- Walker C
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- Walker R
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- Walter J
- Walters RK
- Walton O
- Wang B
- Wang QS
- Wang X
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- Ward D
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- Warrington J
- Washington NL
- Wassall H
- Wasson C
- Watanabe H
- Watanabe K
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- Wendtner CM
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- Whitelaw L
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- Whitton C
- Whyte C
- Wicks SJ
- Wiegrebe S
- Wienbrandt L
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- Wilding L
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- Wilfling S
- Wiliams A
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- Wilkinson B
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- Williams C
- Williams D
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- Winchester J
- Winkler TW
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- Wittig M
- Witzke O
- Wolf-Roberts R
- Wolford BN
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- Wulandari R
- Wylie K
- Wyllie DH
- Wynter I
- Xavier K
- Xue X
- Yagi K
- Yamada M
- Yamada Y
- Yamagata K
- Yamasaki M
- Yang J
- Yaspan B
- Yassen AM
- Yasui Y
- Yates B
- Yatomi M
- Ye C
- Yermakovich D
- Yeung RSM
- Yi X
- Yonekawa A
- Yoo S
- Yoon K
- Yoshida K
- Yoshida S
- Yoshida S
- Yoshida T
- Yoshihara T
- Yoshiya K
- Yoshiyama T
- Young M
- Yue F
- Yun N
- Yáñez CE
- Yáñez Z
- Zainulabid UA
- Zainy T
- Zak A
- Zaki A
- Zamikula J
- Zamudio IPM
- Zanella A
- Zapata-Contreras D
- Zapatamartinez M
- Zarate R
- Zarei N
- Zavaleta DAF
- Zawadzki P
- Zawati MH
- Zborowski AC
- Zeberg H
- Zechner M
- Zhang Q
- Zhao X
- Zheng C
- Zheng T
- Zhlawi HJ
- Zhlawi MWJ
- Zholdybayeva E
- Zhou W
- Zhu W
- Zitter L
- Zoller H
- Zongo O
- Zorloni C
- Zuñiga-Pacheco P
- Zárate RN
- Zúñiga-Ramos J
- Álvarez BG
- Ávila-Arcos MA
- Ávila-Arcos MC
- Özer O
- Überla K
- Þorsteinsdóttir U
- Publication venue
- Nature Research
- Publication date
- 21/06/2023
- Field of study