Complex sine-Gordon-2: a new algorithm for multivortex solutions on the plane

We present a new vorticity-raising transformation for the second integrable complexification of the sine-Gordon equation on the plane. The new transformation is a product of four Schlesinger maps of the Painlev\'{e}-V to itself, and allows a more efficient construction of the $n$-vortex solution than the previously reported transformation comprising a product of $2n$ maps.Comment: Part of a talk given at a conference on "Nonlinear Physics. Theory and Experiment", Gallipoli (Lecce), June-July 2004. To appear in a topical issue of "Theoretical and Mathematical Physics". 7 pages, 1 figur

Two-loop Euler-Heisenberg effective actions from charged open strings

We present the multiloop partition function of open bosonic string theory in the presence of a constant gauge field strength, and discuss its low-energy limit. The result is written in terms of twisted determinants and differentials on higher-genus Riemann surfaces, for which we provide an explicit representation in the Schottky parametrization. In the field theory limit, we recover from the string formula the two-loop Euler-Heisenberg effective action for adjoint scalars minimally coupled to the background gauge field.Comment: 32 pages, 3 eps figures, plain LaTeX. References added, minor changes to the text. Published version, affiliation correcte

Efficient Hardware Design Of Iterative Stencil Loops

A large number of algorithms for multidimensional signals processing and scientific computation come in the form of iterative stencil loops (ISLs), whose data dependencies span across multiple iterations. Because of their complex inner structure, automatic hardware acceleration of such algorithms is traditionally considered as a difficult task. In this paper, we introduce an automatic design flow that identifies, in a wide family of bidimensional data processing algorithms, sub-portions that exhibit a kind of parallelism close to that of ISLs; these are mapped onto a space of highly optimized ad-hoc architectures, which is efficiently explored to identify the best implementations with respect to both area and throughput. Experimental results show that the proposed methodology generates circuits whose performance is comparable to that of manually-optimized solutions, and orders of magnitude higher than those generated by commercial HLS tools

Hyaluronan-carnosine conjugates inhibit Aβ aggregation and toxicity

Alzheimer’s disease is the most common neurodegenerative disorder. Finding a pharmacological approach that cures and/or prevents the onset of this devastating disease represents an important challenge for researchers. According to the amyloid cascade hypothesis, increases in extracellular amyloid-β (Aβ) levels give rise to different aggregated species, such as protofibrils, fibrils and oligomers, with oligomers being the more toxic species for cells. Many efforts have recently been focused on multi-target ligands to address the multiple events that occur concurrently with toxic aggregation at the onset of the disease. Moreover, investigating the effect of endogenous compounds or a combination thereof is a promising approach to prevent the side effects of entirely synthetic drugs. In this work, we report the synthesis, structural characterization and Aβ antiaggregant ability of new derivatives of hyaluronic acid (Hy, 200 and 700 kDa) functionalized with carnosine (Car), a multi-functional natural dipeptide. The bioactive substances (HyCar) inhibit the formation of amyloid-type aggregates of Aβ42 more than the parent compounds; this effect is proportional to Car loading. Furthermore, the HyCar derivatives are able to dissolve the amyloid fibrils and to reduce Aβ-induced toxicity in vitro. The enzymatic degradation of Aβ is also affected by the interaction with HyCar

Dynamic modeling of inter-instruction effects for execution time estimation

The market for embedded applications is facing a growing interest in power consumption issues. The work presented is intended to provide a new model to estimate software-level power consumption of 32-bit microprocessors. This model extends previous ones by considering dynamic inter-instruction effects that take place during code execution, providing a static means to characterize their energy consumption. The model is formally sound; it is conceived for a generic architecture and it has been preliminarily validated on the Intel486/sup TM/ architecture

Impact of the abolition of food handler certification on notification rates of foodborne diseases in Italy

to assess the trends of foodborne diseases in respect of the abolition of food handler certification by Italian Regions

hArtes: Hardware-Software Codesign for Heterogeneous Multicore Platforms

Developing heterogeneous multicore platforms requires choosing the best hardware configuration for mapping the application, and modifying that application so that different parts execute on the most appropriate hardware component. The hArtes toolchain provides the option of automatic or semi-automatic support for this mapping. During test and validation on several computation-intensive applications, hArtes achieved substantial speedups and drastically reduced development times

Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds

Basic mechanisms by which cellular barriers sense and respond to integrity disruptions remain poorly understood. Despite its tenuous structure and constitutive exposure to disruptive strains, the vascular endothelium exhibits robust barrier function. We show that in response to micrometer-scale disruptions induced by transmigrating leukocytes, endothelial cells generate unique ventral lamellipodia that propagate via integrins toward and across these “micro-wounds” to close them. This novel actin remodeling activity progressively healed multiple micro-wounds in succession and changed direction during this process. Mechanical probe-induced micro-wounding of both endothelia and epithelia suggests that ventral lamellipodia formed as a response to force imbalance and specifically loss of isometric tension. Ventral lamellipodia were enriched in the Rac1 effectors cortactin, IQGAP, and p47Phox and exhibited localized production of hydrogen peroxide. Together with Apr2/3, these were functionally required for effective micro-wound healing. We propose that barrier disruptions are detected as local release of isometric tension/force unloading, which is directly coupled to reactive oxygen species–dependent self-restorative actin remodeling dynamics