321 research outputs found
Spontaneous abortion as differential diagnosis of intermittent glomerular proteinuria in inactive systemic lupus erythematosus
In women of childbearing age, severe proteinuria in systemic lupus erythematosus raises concern for renal involvement and pregnancy complications. While persisting renal loss of protein is known to culminate in extensive interventions, intermittent proteinuria in inactive disease requires an adjusted approach. Contextual awareness of this urinary finding is thus essential
Purification and analytical characterization of an anti- CD4 monoclonal antibody for human therapy
A purification process for the monclonal anti-CD4 antibody MAX.16H5 was developed on an analytical scale using (NH&SO,
precipitation, anion-exchange chromatography on MonoQ or Q-Sepharose, hydrophobic interaction chromatography on phenyl-
Sepharose and gel filtration chromatography on Superdex 200. The purification schedule was scaled up and gram amounts of
MAX.16H5 were produced on corresponding BioPilot columns. Studies of the identity, purity and possible contamination by a
broad range of methods showed that the product was highly purified and free from contaminants such as mouse DNA, viruses,
pyrogens and irritants. Overall, the analytical data confirm that the monoclonal antibody MAX.16H5 prepared by this protocol is
suitable for human therapy
Radiographic Damage and Disability in Patients with Ra in Relation To Disease Duration in The Era of Biologics. Long-Term Results from The SCQM Cohort
Identification of Genetic Variants Associated with Response to Methotrexate in Patients with Early Rheumatoid Arthritis: Results from the Optima Study
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