The Ursinus Weekly, January 13, 1947

Ruby staff offers 10% commission for ads obtained • Students receive pledge for F.T.A. Wednesday night • Nominating committee selected by major campus organizations • Thespians raised in club status by Players and Stars • Speaker discusses life\u27s foundation • Debaters continue activities with Temple and Rider • Souerwine appointed president of Cub and Key for next term • Ursinus delegates support measures adopted by Urbana student assembly • Joseph Jones elected to lead newly organized legal society • Dr. Brown selects a drop of blood for pre-med talk • The sudden guest discussed at English Club meeting tonight • French Club elects W. Johnson, M. Hewitt, v.-pres., secretary • C. Garber elected head of YMCA to replace Newlin • Bears topple Dragons, 60-50; Moore, Snyder share honors • Jay Vees drop initial tilt to Drexel scrubs in overtime contest • Footballers name Parks, Detwiler 1946 co-captains • Bears capture second victory; down Fords in spine tingler, 48-46 • Sextet practices for opening game against Albright • Ursinus independents win over Collegeville Commodores, 43-37 • Fire causes slight damage when sparks ignite Fircroft roofhttps://digitalcommons.ursinus.edu/weekly/1650/thumbnail.jp

The Ursinus Weekly, April 21, 1947

Nominations made for YM, MSG heads; men students to ballot on Thursday • Dr. N. McClure names Kurt Wieneke coach of football, wrestling • D. Marple elected WSGA president; other organization leaders chosen • N. Mancini to play for prom on May 2 • Orders for corsages taken until May 2 • Model UN attracts forty-one colleges; Ursinus attends • Pageant based on nutcracker suite selected for May 10 • Princeton captures debating crown at annual tournament • Hilarious show nears final rehearsals as Ronnie Sare directs Very Good Eddie • French movie to be shown • Dr. Brown to speak to pre-meds • A. Souerwine cast as The man ; practice schedule is announced • Dr. Frey addresses German Club on topic of Pennsylvania Dutch • FTA to meet Wednesday night • J. Lownes to speak at banquet; Rosicrucians accept six members • Delegation attends model legislature • Resolution on the death of Dr. Bancroft • Attorney to address legal group • Rev. Platts addresses club • Bears trounce Haverford in opener; bow to LaSalle • Haverford tripped by bears\u27 base-hit barrage in opener • Penn relays to test track stars in first bid to alter marks • Intramurals begin with softball tilts in campus flag race • Explorers\u27 late rally nips bears in home contest • Softball squad prepares for opening tussle with Albright • Dr. Edgar Cale outlines background, presents aspects of U.S. foreign policy • IRC hears report on work of model United Nations\u27 assembly • H. Conner reviews Seeing Things by J. M. Brown for English Club • Total of $146.32 received as coeds\u27 contribution to Red Crosshttps://digitalcommons.ursinus.edu/weekly/1658/thumbnail.jp

The Ursinus Weekly, February 24, 1947

Students schedule spring activities at meeting Monday • Twenty-two make B list of college for spring term • Summer term to run for eight week period from July 7- August 29 • Fifty-six men accept fraternity bids as climax to week of rushing parties • Students to get snowball tickets in supply store • FTA panel gives problems facing beginning teacher • Colors presented to freshman girls by junior advisors • Temptation is topic at vesper gathering • 746 Main St opened to students; M. Hewitt to head dormitory • L. Oddo elected to MSG vacancy • Y to conduct Religion in Life Week from March 12 to 16; speakers engaged • Dr. Dressler to address pre-meds on subject of human monsters • Debaters to meet Gettysburg in return match on labor question • Curtain Club to hold tryouts for The Man who Came to Dinner • Mermaids defeat Bryn Mawr girls in close 30-27 meet • WSSF appeals for material aid to foreign students • Library is location for colorful exhibition of Penna.-Germania items • Swarthmore rips bear title aspirations with 58-49 win in key Middle Atlantics conference hardwood contest • Unbeaten Curtis sets pace in intramural basketball loop race • Sextet wins 24-13 over Penn coeds for third victory • Drexel five dumps bruins in lengthy cage fray, 70-61 • Gurzynski appointed new coach; heads track, assists in football • Drexel jayvees brush cub five, 39-28, in near-brawl cage tilthttps://digitalcommons.ursinus.edu/weekly/1653/thumbnail.jp

The Lantern Vol. 16, No. 3, Spring 1948

• Not So Light • Babba\u27s Luck • Winter Night • God Hath Wrought • Less Than Trivia • What is Progress? • Betrayal • The Key • Journey From a Star • War and Peace • Experiment in Prose Poetry • Dawn • Eternal Question • My Gift • Jazz Fantasy • M.W. Witmerhttps://digitalcommons.ursinus.edu/lantern/1045/thumbnail.jp

AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis

Myotubular myopathy (XLMTM, OMIM 310400) is a severe congenital muscular disease due to mutations in the myotubularin gene (MTM1) and characterized by the presence of small myofibers with frequent occurrence of central nuclei. Myotubularin is a ubiquitously expressed phosphoinositide phosphatase with a muscle-specific role in man and mouse that is poorly understood. No specific treatment exists to date for patients with myotubular myopathy. We have constructed an adeno-associated virus (AAV) vector expressing myotubularin in order to test its therapeutic potential in a XLMTM mouse model. We show that a single intramuscular injection of this vector in symptomatic Mtm1-deficient mice ameliorates the pathological phenotype in the targeted muscle. Myotubularin replacement in mice largely corrects nuclei and mitochondria positioning in myofibers and leads to a strong increase in muscle volume and recovery of the contractile force. In addition, we used this AAV vector to overexpress myotubularin in wild-type skeletal muscle and get insight into its localization and function. We show that a substantial proportion of myotubularin associates with the sarcolemma and I band, including triads. Myotubularin overexpression in muscle induces the accumulation of packed membrane saccules and presence of vacuoles that contain markers of sarcolemma and T-tubules, suggesting that myotubularin is involved in plasma membrane homeostasis of myofibers. This study provides a proof-of-principle that local delivery of an AAV vector expressing myotubularin can improve the motor capacities of XLMTM muscle and represents a novel approach to study myotubularin function in skeletal muscle

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment