Pennsylvania Folklife Vol. 39, No. 3

• The General Store • Pennsylvania German in Public Life • Building a One-Room School: The Dynamics of School Board Decision-Making at the Turn of the 20th Century • Washington Hood: 500th Graduate of the United States Military Academy • Grandmother Schultz • Aldes un Neies (Old and New)https://digitalcommons.ursinus.edu/pafolklifemag/1127/thumbnail.jp

Ursinus College Alumni Journal, August 1962

The President writes • Have gun will travel • The Loyalty Fund committee • Ursinus launches campaign for five million dollars • Alumni must think big • Samuel Bond, Ursinus\u27 architect • Faculty notes • 1962 commencement • Distinguished Teaching • Alumni in the news • \u2762 Loyalty Fund nets $52,942.84 • Results of the 1962 Loyalty Fund campaign • Contributors to the 1962 Loyalty Fund • Best track season in Ursinus history • Baseball • Women\u27s sports • Class notes • Weddings • Births • Necrology • Dr. Eugene H. Miller, \u2733, to speak at Forum • New UCC Church conference • The college sealhttps://digitalcommons.ursinus.edu/alumnijournal/1073/thumbnail.jp

Ursinus College Alumni Journal, August 1964

President\u27s page • The liberal arts curriculum • Commencement 1964 • Dining hall construction • Capital funds campaign contributions total $356,225 • American Alumni Council award • Campus round-up • Sturgis retires • Staiger heads Chem. Dept. • Track team undefeated • Results of 1964 Loyalty Fund campaign • The second mile • Alumni who have paid their pledges in full • Contributors to the 1964 Loyalty Fund • Alumni album: Irwin S. Leinbach, \u2729; Blanch Shirey Wentzel, \u2743; Clarence A. Paine, \u2722; Loretta Podolak Finnegan, \u2760; Jean Bonkoski, \u2768; Jean Ewen Trend, \u2743 • 1914-1964 • Class Notes • Valedictory • Weddings • Births • Necrology • Oldest alumnus dies • The face of the new alumnushttps://digitalcommons.ursinus.edu/alumnijournal/1080/thumbnail.jp

Ursinus College Alumni Journal, August 1965

First words • From the President • Storm warnings from the ancient world • Ferment: Change comes to Ursinus against a backdrop of widespread concern about higher education • A federal tax credit plan for expenses of higher education • The higher mathematics of public education • Pieces of mind, \u2765 • Class of \u2765: An end, a beginning • Grads return to campus on Alumni Day • 1965 Alumni Award • The Evening School breed • George S. Spohn, \u2742, will lead the Alumni Centennial Fund • 1965 Loyalty Fund annual report • This is not a drill!: Ursinus men play key roles in air strikes on North Vietnam communists • Art is a search • Letters: A gift that lives; Amman adventure • Campus clippings • The will to give • Sporting scene • Hydrologist studies the rise and fall of water supply • Class notebook • Weddings • Births • In memoriam • End quotes: Can we be equal and excellent too?https://digitalcommons.ursinus.edu/alumnijournal/1084/thumbnail.jp

Ursinus College Alumni Journal, November 1963

The President writes • A kaleidoscopic view of the student • The student looks at himself • The faculty comments • Modern German literature • Founders\u27 Day • Spangler portrait unveiled • Dr. Helfferich\u27s remarks • Board elects two members • Campaign receipts total $223,416 • Eshbach resigns • Loyalty Fund vis-a-vis capital funds campaign • Wills • Ursinus: 1963-64 • Staiger\u27s latest publication • Mr. and Mrs. Ursinus visit U.C. • Rothenberger honored • Howard listed • Ursinus entertains neighbors • Travel seminar • Student teachers rank high • They carry big sticks • 1963-64 winter sports schedules • Homecoming • Football • Hockey all-stars • G. Sieber Pancoast, \u2737 • Class notes • Weddings • Births • Necrologyhttps://digitalcommons.ursinus.edu/alumnijournal/1078/thumbnail.jp

Modulation of GSK-3β activity in Venezuelan equine encephalitis virus infection

Alphaviruses, including Venezuelan Equine Encephalitis Virus (VEEV), cause disease in both equine and humans that exhibit overt encephalitis in a significant percentage of cases. Features of the host immune response and tissue-specific responses may contribute to fatal outcomes as well as the development of encephalitis. It has previously been shown that VEEV infection of mice induces transcription of pro-inflammatory cytokines genes (e.g., IFN-γ, IL-6, IL-12, iNOS and TNF-α) within 6 h. GSK-3β is a host protein that is known to modulate pro-inflammatory gene expression and has been a therapeutic target in neurodegenerative disorders such as Alzheimer\u27s. Hence inhibition of GSK-3β in the context of encephalitic viral infections has been useful in a neuroprotective capacity. Small molecule GSK-3β inhibitors and GSK-3β siRNA experiments indicated that GSK-3β was important for VEEV replication. Thirty-eight second generation BIO derivatives were tested and BIOder was found to be the most potent inhibitor, with an IC50 of ~0.5 µM and a CC50 of \u3e100 µM. BIOder was a more potent inhibitor of GSK-3β than BIO, as demonstrated through in vitro kinase assays from uninfected and infected cells. Size exclusion chromatography experiments demonstrated that GSK-3β is found in three distinct complexes in VEEV infected cells, whereas GSK-3β is only present in one complex in uninfected cells. Cells treated with BIOder demonstrated an increase in the anti-apoptotic gene, survivin, and a decrease in the pro-apoptotic gene, BID, suggesting that modulation of pro- and anti-apoptotic genes contributes to the protective effect of BIOder treatment. Finally, BIOder partially protected mice from VEEV induced mortality. Our studies demonstrate the utility of GSK-3β inhibitors for modulating VEEV infection

Ursinus College Alumni Journal, March 1962

President\u27s page • Pennsylvania Female College • College souvenirs: Class of 1862 • Inside India • James E. Wagner elected Vice-President of Ursinus • New power plant begun • New offices • Bequests committee formed • Has America neglected her creative minority? • Announcing the second annual Alumni Seminar • Jessie Royer Greaves, \u2792, recipient of first alumni award • Nominees for Alumni Association offices • Mid-year report of 1962 Loyalty Fund campaign • From grey flannel to Alaskan seal • Ursinus homecoming in Alaska • Wrestling • Girls\u27 basketball • Basketball • Ursinus ambassadors abroad • Class notes • Weddings • Births • Necrology • Ursinus Women\u27s Club • Regionals • Alumni Dayhttps://digitalcommons.ursinus.edu/alumnijournal/1074/thumbnail.jp

Ursinus College Alumni Journal, November 1962

The President\u27s page • When the shades of evening gather • The frontier Dr. Toynbee forgot • Founders\u27 Day • Ralph F. Wismer dies • Ursinus: The man and his work • New professors • Maurice O. Bone • Nine foreign students at Ursinus • Forums • Report from the Admissions Office • Freshmen Whose Parents are Alumni • Homecoming • News of preceptresses • Summer maintenance • Co-eds work with Indians • Parents\u27 Day • The bread and wine mission • Progress report • How scholarships are founded • Capital funds campaign • Dr. Helfferich says Thank you • Area dinners • Dr. Wagner reports on his trip to Nigeria • Football • Hockey • Lacrosse • Basketball • Wrestling • New wrestling coach • Vernon Morgan \u2761 • New mascot • Allen C. Harman \u2726 • Craig R. Reckard \u2762 • Kenneth S. Kauffman \u2724 • Dorothy J. Marple \u2748 • James J. Peifer \u2748 • Constitution changes proposed • Class notes • Births • Necrology • Weddings • The Innkeepershttps://digitalcommons.ursinus.edu/alumnijournal/1075/thumbnail.jp