Gawan MacDowell Über Figurenrede in Wolframs Parzival und in Joyces Ulysses

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Transient but not permanent benefit of neuronal progenitor cell therapy after traumatic brain injury: potential causes and translational consequences

Background:: Numerous studies have reported a beneficial impact of neural progenitor cell transplantation on functional outcome after traumatic brain injury (TBI) during short and medium follow-up periods. However, our knowledge regarding long-term functional effects is fragmentary while a direct comparison between local and systemic transplantation is missing so far. Objectives:: This study investigated the long-term (12 week) impact of human fetal neuronal progenitor cell (hNPC) transplantation 24 h after severe TBI in rats. Methods:: Cells were either transplanted stereotactically (1 × 105) into the putamen or systemically (5 × 105) via the tail vein. Control animals received intravenous transplantation of vehicle solution. Results: An overall functional benefit was observed after systemic, but not local hNPC transplantation by area under the curve analysis (p < 0.01). Surprisingly, this effect vanished during later stages after TBI with all groups exhibiting comparable functional outcomes 84 days after TBI. Investigation of cell-mediated inflammatory processes revealed increasing microglial activation and macrophage presence during these stages, which was statistically significant after systemic cell administration (p < 0.05). Intracerebral hNPC transplantation slightly diminished astrogliosis in perilesional areas (p < 0.01), but did not translate into a permanent functional benefit. No significant effects on angiogenesis were observed among the groups. Conclusion: Our results suggest the careful long-term assessment of cell therapies for TBI, as well as to identify potential long-term detrimental effects of such therapies before moving on to clinical trials. Moreover, immunosuppressive protocols, though widely used, should be rigorously assessed for their applicability in the respective setup

Asymmetrische Polanordnung als fertigungsoptimierte Methode der Nutrastmomentreduzierung am Beispiel eines permanentmagnetisch erregten Synchrongenerators für Kleinwindenergieanlagen

In diesem Beitrag wird eine fertigungsoptimierte Methode der Nutrastmomentreduzierung durch Magnetverschiebung am Beispiel eines Synchrongenerators für Kleinwindenergieanlagen mit in die Läuferoberfläche eingelassenen Permanentmagneten vorgestellt. Auf Grundlage der Drehfeldtheorie wird ein analytisches Berechnungsmodell unter Einbezug der Magnetverschiebung zur Bestimmung des Nutrastmoments entwickelt und mit FEM-Simulationen verifiziert. Durch experimentelle Untersuchung eines gefertigten Prototyps wird der optimierende Effekt der Magnetverschiebung nachgewiesen und mit einem Referenzläufer mit ungeschrägt, symmetrisch verteilten Polen verglichen. Abschließend werden mögliche Ursachen für die verbleibenden Abweichungen identifiziert und Ansätze für die weiteren Betrachtungen abgeleitet.A production-optimized method of reducing cogging torque by magnet shifting using the example of a synchronous generator for small wind turbines with a rotor with inset surface magnets is proposed in this paper. On the basis of rotating field theory an analytical calculation model is developed taking into account the magnet shifting for determination of cogging torque. The analytical results are verified with FEM simulations. By experimental investigation of a manufactured prototype, the optimizing effect of magnet shifting is verified and compared to a rotor with symmetrically distributed poles. Finally, possible reasons for remaining discrepancies are identified and approaches for further considerations are presented

Cerebrovascular Insult as Presenting Symptom of Neurofibromatosis Type 2 in Children, Adolescents, and Young Adults

Background and Purpose: Neurofibromatosis Type 2 (NF2) is an autosomal-dominant tumor-prone disorder characterized by the manifestations of central nervous system lesions. However, the first clinical signs of disease are often non-tumorous. Cerebrovascular insults are known in NF2, however, not yet described as first symptom in young NF2 patients.Methods: Magnetic resonance image scans of 298 NF2 patients treated in our neurofibromatosis center in Tübingen from 2003 to 2017 were retrospectively evaluated focusing on presence of aneurysms and ischemic stroke. Clinical data were used to clarify whether or not ischemic stroke or aneurysm rupture were the first presentation of disease. Blood of the patients were subjected to genetic screening for constitutional NF2 mutations.Results: We identified 5 cases under age of 25 years with aneurysms or ischemic stroke. Among them three had ischemic strokes of the brain stem and one aneurysmal subarachnoid hemorrhage as the first symptom of the disease. Incidental finding of 2 intracranial aneurysm occurred in one patient. All aneurysms were clipped. Patients with ischemia suffered from dysarthria, gait disturbances, dizziness, and hemiparesis. Residual signs of hemiparesis and dysarthria persisted in one patient. All others fully recovered from the cerebrovascular insult. Bilateral vestibular schwannomas and intracranial meningiomas were found in all five patients.Conclusions: A cerebrovascular insult in the vertebrobasilar territory may occur as first symptom of disease in young NF2 patients. The brain stem seems to be especially prone to ischemic stroke. Multicenter studies on large NF2 cohorts are needed to determine the prevalence and pattern of cerebrovascular insults and disease in NF2 patients

Detection of volatiles undergoing sublimation from 67P/Churyumov-Gerasimenko coma particles using ROSINA/COPS. II. The nude gauge

In an earlier study, we reported that the ram gauge of the COmet Pressure Sensor (COPS), one of the three instruments of the Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA), could be used to obtain information about the sublimating content of icy particles, made up of volatiles and conceivably refractories coming from comet 67P/Churyumov-Gerasimenko. In this work, we extend the investigation to the second COPS gauge, the nude gauge. In particular, we analyse the volume of the volatile content of coma particles, along with a search for possible dependencies between the nude gauge detection rate (i.e. the rate at which icy particles are detected by the nude gauge) and the position of the Rosetta spacecraft. We also investigate the correlations of the nude gauge detection rate with the quantities associated with cometary activity. Although it was not originally designed for such a purpose, the COPS nude gauge has been able to detect $\sim$67000 features generated by the sublimation of the volatile content of icy particles. The nude gauge detection rate follows a trend that is inversely proportional to the heliocentric distance. This result is interpreted as a confirmation of a possible relation between the nude gauge detection rate and cometary activity. Thus, we compared the former with parameters related to cometary activity and obtained significant correlations, indicating that the frequency of icy particle detection is driven by cometary activity. Furthermore, by representing the volatile part of the icy particles as equivalent spheres with a density of 1 g cm$^{-3}$, we obtained a range of diameters between 60 and 793 nanometres, with the smaller ones ($<390\,\mathrm{nm}$ in diameter) having a size distribution power index of $-4.79\pm 0.26$.Comment: 12 pages, 10 figures, accepted for publication in A&

Detection of volatiles undergoing sublimation from 67P/Churyumov-Gerasimenko coma particles using ROSINA/COPS. I. The ram gauge

The ESA Rosetta mission has allowed an extensive in-situ study of comet 67P/Churyumov-Gerasimenko. In measurements performed by the ram gauge of the on-board COmet Pressure Sensor (COPS), features have been observed that deviate from the nominal ram gauge signal. These are attributable to the sublimation of the volatile fraction of cometary icy particles containing volatiles and refractories. The objective of this work is the investigation of the volatile content of icy particles that entered the COPS ram gauge. The ram gauge measurements are inspected for features that we associate to the sublimation of the volatile component of cometary particles impacting the instrument. All sublimation features with high enough signal to noise ratio are modelled by fitting one or more exponential decay functions. The parameters of these fits are used to categorise different compositions of the sublimating component. From features attributable to ice sublimation, we infer the detection of 73 icy particles containing volatiles. 25 detections have enough volatile content for an in-depth study. From the values of the exponential decay constants, we classified the 25 inferred icy particles into three types, interpreted as different volatile compositions, possibly further complicated by different morphologies. Available data do not give indication as to which molecules compose the different types. Nevertheless, we can estimate the total volume of volatiles, expressed as the diameter of an equivalent sphere of water (density of 1 g cm$^{-3}$). This was found to be on the order of hundreds of nanometres.Comment: 9 pages, 8 figures, 2 tables, published in A&A, figures with better resolutio

PEDOT–CNT Composite Microelectrodes for Recording and Electrostimulation Applications: Fabrication, Morphology, and Electrical Properties

Composites of carbon nanotubes and poly(3,4-ethylenedioxythiophene, PEDOT) and layers of PEDOT are deposited onto microelectrodes by electropolymerization of ethylenedioxythiophene in the presence of a suspension of carbon nanotubes and polystyrene sulfonate. Analysis by FIB and SEM demonstrates that CNT–PEDOT composites exhibit a porous morphology whereas PEDOT layers are more compact. Accordingly, capacitance and charge injection capacity of the composite material exceed those of pure PEDOT layers. In vitro cell culture experiments reveal excellent biocompatibility and adhesion of both PEDOT and PEDOT–CNT electrodes. Signals recorded from heart muscle cells demonstrate the high S/N ratio achievable with these electrodes. Long-term pulsing experiments confirm stability of charge injection capacity. In conclusion, a robust fabrication procedure for composite PEDOT–CNT electrodes is demonstrated and results show that these electrodes are well suited for stimulation and recording in cardiac and neurophysiological research