Practical recommendations for fertility preservation in women by the FertiPROTEKT network. Part I: Indications for fertility preservation

Purpose Most guidelines about fertility preservation are predominantly focused on scientific evidence, but are less practically orientated. Therefore, practically oriented recommendations are needed to support the clinician in daily practice. Methods A selective literature search was performed based on the clinical and scientific experience of the authors, focussing on the most relevant diseases and gynaecological cancers. This article (Part I) provides information on topics that are essential for the fertility preservation indication, such as disease prognosis, disease therapy and its associated risks to fertility, recommending disease-specific fertility preservation measures. Part II specifically focusses on fertility preservation techniques. Results In breast cancer patients, fertility preservation such as ovarian tissue and oocyte cryopreservation is especially recommended in low-stage cancer and in women < 35 years of age. In Hodgkin's lymphoma, the indication is mainly based on the chemotherapy regime as some therapies have very low, others very high gonadotoxicity. In borderline ovarian tumours, preservation of fertility usually is achieved through fertility sparing surgery, ovarian stimulation may also be considered. In cervical cancer, endometrial cancer, rheumatic diseases and other malignancies such as Ewing sarcoma, colorectal carcinoma, non-Hodgkin lymphoma, leukaemia etc., several other factors must be considered to enable an individual, stage-dependent decision. Conclusion The decision for or against fertility preservation depends on the prognosis, the risks to fertility and individual factors such as prospective family planning

Report and preliminary results of METEOR-cruise M 29/1: Buenos-Aires -Montevideo, 17.6.-13.7.94

During METEOR cruise M 29/1 the shipboard acoustical systems HYDROSWEEP and PARASOUND were used on a 24 hour schedule to record continuous high resolution bathymetric and sediment echosounding profiles. The digitization and storage of the echosounding seismograms were realized by usage of the software package PARADIGMA (Spiess, 1992). The underway geophysical program along several profiles on the Argentine continental margin serves the long term research program Sonderforschungsbereich 261, the complete coverage of the South Atlantic Ocean with a net of sampling stations and geophysical profiles. Along the profiles the recorded data provided valuable information for finding suitable coring stations from different sedimental environments on the continental margin, which can be well discriminated by their different echotypes. (orig.)Available from TIB Hannover: RO 7630(58) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDeutsche Forschungsgemeinschaft (DFG), Bonn (Germany)DEGerman