Reporting ethics committee approval and patient consent by study design in five general medical journals.

BACKGROUND: Authors are required to describe in their manuscripts ethical approval from an appropriate committee and how consent was obtained from participants when research involves human participants. OBJECTIVE: To assess the reporting of these protections for several study designs in general medical journals. DESIGN: A consecutive series of research papers published in the Annals of Internal Medicine, BMJ, JAMA, Lancet and The New England Journal of Medicine between February and May 2003 were reviewed for the reporting of ethical approval and patient consent. Ethical approval, name of approving committee, type of consent, data source and whether the study used data collected as part of a study reported elsewhere were recorded. Differences in failure to report approval and consent by study design, journal and vulnerable study population were evaluated using multivariable logistic regression. RESULTS: Ethical approval and consent were not mentioned in 31% and 47% of manuscripts, respectively. 88 (27%) papers failed to report both approval and consent. Failure to mention ethical approval or consent was significantly more likely in all study designs (except case-control and qualitative studies) than in randomised controlled trials (RCTs). Failure to mention approval was most common in the BMJ and was significantly more likely than in The New England Journal of Medicine. Failure to mention consent was most common in the BMJ and was significantly more likely than in all other journals. No significant differences in approval or consent were found when comparing studies of vulnerable and non-vulnerable participants. CONCLUSION: The reporting of ethical approval and consent in RCTs has improved, but journals are less good at reporting this information for other study designs. Journals should publish this information for all research on human participants

CSF lactate dehydrogenase activity in patients with Creutzfeldt-Jakob disease exceeds that in other dementias

The diagnosis of Creutzfeldt- Jakob disease (CJD) is still made by exclusion of other dementias. We now evaluated lactate dehydrogenase (LDH) in the cerebrospinal fluid (CSF) as a possible additional diagnostic tool. CSF LDH levels of patients with CJD ( n = 26) were compared with those in other dementias ( n = 28). LDH isoenzymes were determined in a subset ( n = 9). Total LDH and isoenzyme LDH-1 were significantly higher, whereas the fractions of LDH-2 and LDH-3 were significantly lower in CJD patients. We conclude that in addition to established CSF parameters, LDH and its isoenzymes might serve as a further help to discriminate between CJD and other dementias. Copyright (C) 2004 S. Karger AG, Basel

Computational fluid dynamics benchmark dataset of airflow in tracheas

Computational Fluid Dynamics (CFD) is fast becoming a useful tool to aid clinicians in pre - surgical planning through the ability to provide inform ation that could otherwise be extremely difficult if not impossible to obtain. However, in order to provide clinically relevant metrics, the accuracy of the computational method must be sufficiently high. There are many alternative methods employed in the process of performing CFD simulations within the airways, including different segme ntation and meshing strategies, as well as alternative approaches to solving the Navier - Stokes equations. However, as in vivo validation of the simulated flow patter ns within the airways is not possible, little exists in the way of validation of the various simulation techniques. The data presented here consists of very highly resolved flow data. The degree of resolution is compared to the highest necessary resolution s of the Kolmogorov length and time scales. Therefore this data is ideally suited to act as a benchmark case to which cheaper comput ational methods may be compared. A dataset and solution setup for one such more efficient method, large eddy simulation (LES ), is also presented

Kaon properties and cross sections in nuclear medium

Results for the $\pi + N \to \Lambda, \Sigma + K$ reactions in nuclear matter of Ref. nucl-th/0004011 are presented. To evaluate the in-medium modification of the reaction amplitude as a function of the baryonic density we introduce relativistic, mean-field potentials for the initial, final and intermediate mesonic and baryonic states in the resonance model. These vector and scalar potentials were calculated using the quark meson coupling model. Contrary to earlier work which has not allowed for the change of the cross section in medium, we find that the data for kaon production at SIS energies are consistent with a repulsive $K^+$-nucleus potential.Comment: 5 pages, 3 postscript figures included, uses iopart.cls and iopart10.clo (included), presented by K.T. at the 5th International Conference on Strangeness in Quark Matter, July 20 - 25, 2000, Berkeley, California, to be published in the proceedings, J. Phys. G. An explanation has been added in Sec. 3 with a new figur

The effects of subliminal or supraliminal sadness induction on the sense of body ownership and the role of dissociative symptoms

Previous research has shown that emotions can alter our sense of ownership. Whether this relationship is modulated by differences in emotion experience and awareness, however, remains unclear. We investigated this by comparing the susceptibility to the rubber hand illusion (RHI) between participants who were either exposed to a low-arousing emotion induction (sadness) or placed in a neutral control group. Several factors that might influence this relationship were considered: dissociative symptoms were included to observe if a sadness induction led to a higher RHI score in participants scoring high in dissociation, as a result of detached emotion experience. Whether the level of awareness of the emotion mattered was also tested, as subliminal processing was shown to require less focal attention. Therefore, our sample (N = 122) was divided into three experimental groups: Sad pictures were presented to two of the three groups differing in presentation mode (subliminal: n = 40, supraliminal: n = 41), neutral pictures were presented supraliminally to the control group (n = 41). Additionally, the effects of slow (3 cm/s) and fast (30 cm/s) stroking, applied either synchronously or asynchronously, were examined as the comforting effects of stroking might interfere with the emotion induction. Results showed that the supraliminal sadness induction was associated with a stronger subjective illusion, but not with a higher proprioceptive drift compared to the subliminal induction. In addition, a stronger subjective illusion after fast and synchronous stroking was found compared to slow and asynchronous stroking. A significant proprioceptive drift was detected independent of group and stroking style. Both slow and synchronous stroking were perceived as more comforting than their respective counterparts. Participants with higher dissociative symptoms were more susceptible to the subjective illusion, especially in the supraliminal group in the synchronous condition. We concluded that individual differences in emotion experience are likely to play a role in body ownership. However, we cannot clarify at this stage whether differences in proprioception and the subjective illusion depend on the type of emotion experienced (e.g. different levels of arousal) and on concomitant changes in multisensory integration processes