262 research outputs found

    The Relationship Between Self-Esteem, Ambivalence, and Relationship Outcomes within Romantic Partnerships

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    The current study analyzes self-esteem and the apparent mood of one’s partner as predictors of perceived responsibility, level of felt rejection, and relationship satisfaction in romantic relationships. The study hypothesizes that ambivalence will act as a moderating variable between self-esteem and romantic relationship outcomes. Previous research on the topic suggests that self-esteem is associated with how participants react to their romantic partner when they are in a specific mood. The current study will be one of the first to examine how ambivalence affects self-esteem’s effect on romantic relationships. The results replicate previous research, showing that self-esteem interacts with partner’s mood to predict perceived responsibility. Results also show that level of rejection and relationship satisfaction are associated with self-esteem. Ambivalence was not a significant moderator of these effects. Additionally, self-concept clarity was a significant predictor of how responsible participants felt when their romantic partner was in a certain mood. Keywords: ambivalence, romantic relationships, self-esteem, self-concept clarity, responsibility, rejection, satisfactio

    Compendium of linear accelerators - 1976

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    Optimal and heuristic policies for lot sizing with learning in setups

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    We develop heuristic and optimal methods for determining lot sizes when setup cost reductions occur over time due to emphasis on continuous improvement, learning effects and incremental process changes. Our heuristic methods are intuitively appealing, easy to implement, require little information about setup costs, and have low computational burden. Computational studies show that choosing the appropriate heuristic yields nearly optimal solutions. Recommendations for choosing the appropriate heuristic are also provided. The optimal method developed in this paper is also useful to managers for evaluating investments in hardware and/or worker training for setup reduction. Concepts and methods are illustrated with numerical examples. Managerial implications of using our policies are discussed.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146803/1/joom229.pd

    The development of a successful satellite bone marrow transplant (BMT) unit as a model for health care outreach

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    A study of FMS part type selection approaches for short-term production planning

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    This research compares seven approaches from the literature to the selection of part types for simultaneous production over the next time horizon. A flexible approach to the selection of part types and the simultaneous determination of their mix ratios so as to balance aggregate machine workloads is presented. Constraints on tool magazine capacity are considered. Simulation studies are conducted on realistic, detailed models of flexible flow systems (FFSs) configured as pooled machines of equal sizes. The simulated settings are constructed to evaluate the impact of such factors as blocking, transportation, buffer utilizations, and fixture requirements and limitations of various types.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45438/1/10696_2004_Article_BF00713157.pd

    High-dose paclitaxel in combination with doxorubicin, cyclophosphamide and peripheral blood progenitor cell rescue in patients with high-risk primary and responding metastatic breast carcinoma: toxicity profile, relationship to paclitaxel pharmacokinetics and short-term outcome

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    We assessed the feasibility and pharmacokinetics of high-dose infusional paclitaxel in combination with doxorubicin, cyclophosphamide, and peripheral blood progenitor cell rescue. Between October 1995 and June 1998, 63 patients with high-risk primary [stage II with ≥ 10 axillary nodes involved, stage IIIA or stage IIIB inflammatory carcinoma (n = 53)] or with stage IV responsive breast cancer (n = 10) received paclitaxel 150–775 mg/m2infused over 24 hours, doxorubicin 165 mg/m2as a continuous infusion over 96 hours, and cyclophosphamide 100 mg kg–1. There were no treatment-related deaths. Dose-limiting toxicity was reversible, predominantly sensory neuropathy following administration of paclitaxel at the 775 mg/m2dose level. Paclitaxel pharmacokinetics were non-linear at higher dose levels; higher paclitaxel dose level, AUC, and peak concentrations were associated with increased incidence of paraesthesias. No correlation between stomatitis, haematopoietic toxicities, and paclitaxel dose or pharmacokinetics was found. Kaplan–Meier estimates of 30-month event-free and overall survival for patients with primary breast carcinoma are 65% (95% CI; 51–83%) and 77% (95% CI; 64–93%). Paclitaxel up to 725 mg/m2infused over 24 hours in combination with with doxorubicin 165 mg/m2and cyclophosphamide 100 mg kg–1is tolerable. A randomized study testing this regimen against high-dose carboplatin, thiotepa and cyclophosphamide (STAMP V) is currently ongoing. © 2001 Cancer Research Campaign http://www.bjcancer.co
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