Fast and Accurate Pressure-Drop Prediction in Straightened Atherosclerotic Coronary Arteries

Atherosclerotic disease progression in coronary arteries is influenced by wall shear stress. To compute patient-specific wall shear stress, computational fluid dynamics (CFD) is required. In this study we propose a method for computing the pressure-drop in regions

Contrast-enhanced micro-CT imaging in murine carotid arteries: A new protocol for computing wall shear stress

Background: Wall shear stress (WSS) is involved in the pathophysiology of atherosclerosis. The correlation between WSS and atherosclerosis can be investigated over time using a WSS-manipulated atheroscleroti

Geometry-based pressure drop prediction in mildly diseased human coronary arteries

Pressure drop (△. p) estimations in human coronary arteries have several important applications, including determination of appropriate boundary conditions for CFD and estimation of fractional flow reserve (FFR). In this study a △. p prediction was made based on geometrical features derived from patient-specific imaging data.Twenty-two mildly diseased human coronary arteries were imaged with computed tomography and intravascular ultrasound. Each artery was modelled in three consecutive steps: from straight to tapered, to stenosed, to curved model. CFD was performed to compute the additional △. p in each model under steady flow for a wide range of Reynolds numbers. The correlations between the added geometrical complexity and additional △. p were used to compute a predicted △. p. This predicted △. p based on geometry was compared to CFD results.The mean △. p calculated with CFD was 855±666. Pa. Tapering and curvature added significantly to the total △. p, accounting for 31.4±19.0% and 18.0±10.9% respectively at Re=250. Using tap

Functional and anatomical measures for outflow boundary conditions in atherosclerotic coronary bifurcations

The aim of this research was finding the influence of anatomy-based and functional-based outflow boundary conditions for computational fluid dynamics (CFD) on fractional flow reserve (FFR) and wall shear stress (WSS) in mildly diseased coronary bifurcations.For 10 patient-specific bifurcations thr