620 research outputs found
Proceedings: Pancreatic islet cell and other tumours induced in rats by heliotrine- a mono-ester pyrrolizidine alkaloid; the effects of additional treatment with nicotinamide.
Get PDF
The Mechanisms of Action of the Carcinogenic Nitroso and Related Compounds
Get PDFIt is suggested that the proximate carcinogenic forms of dialkylnitrosamines are their oxidation products, which retain the alkylnitrosamino moiety, but have acquired a carbonyl function as a result of omega or beta oxidation of an alkyl group. Such metabolites resemble the locally acting carcinogenic “nitrosamides” and probably have become multifunctional. Their functional groups, being in close proximity, could ensure binding in a concerted manner with apposite reactive centres of chromatin to form a firm bridge, for example, between an amino group of nucleic acid base and thiols of protein chains
Proceedings: The mode of action of carcinogens which can induce tumours with a single dose: a new hypothesis.
Get PDF
Proceedings: Zearalenone in the diet, podophyllotoxin in the wood shavings bedding, are likely to affect the incidence of "spontaneous" tumours among laboratory animals.
Get PDFProceedings: Is alkylation of nicotinamide the cause of liver necrosis that follows large doses of hepatocarcinogens?
Get PDFNasal and other tumours in rats given 3,4,5-trimethoxy-cinnamaldehyde, a derivative of sinapaldehyde and of other , -unsaturated aldehydic wood lignin constituents.
Get PDF- …
