Accelerated ripening in chemically fueled emulsions

Chemically fueled emulsions are solutions with droplets made of phase-separated molecules that are activated and deactivated by a chemical reaction cycle. These emulsions play a crucial role in biology as a class of membrane-less organelles. Moreover, theoretical studies show that droplets in these emulsions can evolve to the same size or spontaneously self-divide when fuel is abundant. All of these exciting properties, i. e., emergence, decay, collective behavior, and self-division, are pivotal to the functioning of life. However, these theoretical predictions lack experimental systems to test them quantitively. Here, we describe the synthesis of synthetic emulsions formed by a fuel-driven chemical cycle, and we find a surprising new behavior, i. e., the dynamics of droplet growth is regulated by the kinetics of the fuel-driven reaction cycle. Consequently, the average volume of these droplets grows orders of magnitude faster compared to Ostwald ripening. Combining experiments and theory, we elucidate the underlying mechanism

Proceedings of the 2nd Workshop on Flavor Symmetries and Consequences in Accelerators and Cosmology (FLASY12)

These are the proceedings of the 2nd Workshop on Flavor Symmetries and Consequences in Accelerators and Cosmology, held 30 June 2012 - 4 July 2012, Dortmund, Germany.Comment: Order 400 pages, several figures including the group picture v2: corrected author list and contributio

Therapeutic targets and microenvironment in sequential biopsies of classical Hodgkin lymphoma at diagnosis and relapse

Classical Hodgkin lymphoma is dominated by the non-neoplastic microenvironment, while the neoplastic Hodgkin-Reed-Sternberg cells compose only a minority of cells in the lymphoma tissue. Both the Hodgkin-Reed-Sternberg cells due to their expression of CD30 and PD-L1 and the microenvironment with abundant T cells and expression of PD1 are specifically targeted by new treatment concepts. We aimed to understand the dynamics of therapeutic targets in patients treated with conventional chemotherapy. We analyzed sequential biopsy specimens obtained at diagnosis and at relapse from the same patient for morphology, immunophenotype, and microenvironmental components. The morphological subtype changed between primary and relapse biopsy in 20% of cases. The immunophenotype was stable with respect to CD30, CD3, and LMP1 but variable with respect to CD15 and CD20 expression. Gene expression revealed 8 upregulated and 20 downregulated genes at relapse (p <= 0.05) with a consistent logarithmic fold change direction in at least 75% of all cases. For PD1, we found discrepant results between gene expression analysis (decrease at relapse) and number of PD1-positive cells assessed by immunohistochemistry (unchanged at relapse). PD-L1 in the neoplastic cells appeared unchanged between primary diagnosis and relapse. The expression of the therapeutic targets CD30, PD1, and PD-L1 can reliably be assessed in tumor specimen at first diagnosis and is unchanged under conventional chemotherapy

Hydraulic engineering in the 21st century: Where to?

For centuries, hydraulic engineers were at the forefront of science. The last forty years marked a change of perception in our society with a focus on environmental sustainability and management, particularly in developed countries. Herein, the writer illustrates his strong belief that the future of hydraulic engineering lies upon a combination of innovative engineering, research excellence and higher education of quality. This drive continues a long tradition established by eminent scholars like Arthur Thomas IPPEN, John Fisher KENNEDY and Hunter ROUSE

Masonry dams : analysis of the historical profiles of Sazilly, Delocre and Rankine

The significant advances in masonry dam design that took place in the second half of the 19th century are analyzed and discussed within the context of the historical development of dam construction. Particular reference is made to the gravity dam profiles proposed by Sazilly, Delocre and Rankine, who pioneered the application of engineering concepts to dam design, basing the dam profile on the allowable stresses for the conditions of empty and full reservoir. These historical profiles are analyzed taking into consideration the present safety assessment procedures, by means of a numerical application developed for this purpose, based on limit analysis equilibrium methods, which considers the sliding failure mechanisms, the most critical for these structures. The study underlines the key role of uplift pressures, which was only addressed by Lévy after the accident of Bouzey dam, and provides a critical understanding of the original design concepts, which is essential for the rehabilitation of these historical structures.This work has been funded by FCT (Portuguese Foundation for Science and Technology) through the PhD grant SFRH/BD/43585/2008, for which the first author is grateful

Trayectorias y desafíos de la historiografía de los museos de historia natural en América Del Sur

Powerful tools of interchange and circulation of data and specimens, Natural History museums constituted themselves in several Latin-American countries, such as Argentine and Brazil as privileged loci of epistemic infrastructure since the nineteenth century. The museums gathered huge amounts of collections of surveys of territories and people, always proposed as comprehensive, ultimate and exhaustive endeavors, which made those institutions face the challenges of not only storing and displayng the collections and specimens but also how to order the latter in archives and catalogues that would make them intelligible. Problematizing issues already present in the nowadays consistent literature, including the Latin-American contribution, on museums, the paper discusses among other themes, the acritical identification between museums and the representation of nations and the recurrent notion of museums as place of memory. It proposes as a challenge to the new generation of scholar to ponder how to write these histories incorporating their human and non-human agents as well as the set of events and circunstances that generated their sucesses and failures.En el siglo XIX los museos de historia natural de América del Sur se constituyeron en instrumentos clave para el intercambio y la circulación de datos y especímenes y, en ese sentido, en loci privilegiados de la infraestructura de las ciencias y del saber. Almacenaron tal cantidad de objetos y colecciones que los organizadores de estas instituciones se enfrentaron al problema de cómo guardarlos y exhibirlos dándoles un orden que pudiera entenderse. Por eso, los museos no pueden separarse de la historia del papel, del archivo y de los catálogos. Este artículo repasa algunas cuestiones de la historiografía producida en las últimas décadas, discutiendo, entre otras cosas, la identificación acrítica entre museos, memoria y representación de la nación. A su vez, propone el desafío de cómo escribir la historia de los museos incorporando los agentes humanos y no humanos y el conjunto de circunstancias que sustentan sus éxitos y fracasos

Matriz de relación primaria en casos de niños y niñas con problemas de aprendizaje

La relación entre las dificultades de aprendizaje (DA) y el contexto relacional primario del niño o niña que las presenta, es un aspecto importante reportado en la literatura y en la práctica clínica, y constituye un factor esencial en la comprensión del fenómeno de las DA. Nuestro objetivo en el estudio fue comprender la historia del desarrollo relacional de nueve niños y niñas con DA en la ciudad de Medellín, Colombia, para encontrar relaciones de sentido entre dicha historia y sus DA. La metodología utilizada fue cualitativa desde el enfoque hermenéutico-fenomenológico. Encontramos una dinámica de relación primaria caracterizada por ansiedad y apoyo constante al niño o niña por parte de la madre, y por un padre por fuera de la relación madre - niño o niña. Esa dinámica se reproduce en las relaciones con otras personas y situaciones, favoreciendo la emergencia de un niño o niña en un lugar de discapacidad.-1. Introducción. -2. Metodología. -3. Marco de Referencia: Matriz de Relación Primaria y Aprendizaje. -4. Situaciones Problemáticas: Una Constante en el Desarrollo. -5. Matriz de Relación Primaria: Vínculo estrecho Madre-hijo o hija y un Padre al Margen. 6. Apoyo: Contexto de Desarrollo. 7. Discusión. Lista de Referencias