c-Jun Regulates Eyelid Closure and Skin Tumor Development through EGFR Signaling

AbstractTo investigate the function of c-Jun during skin development and skin tumor formation, we conditionally inactivated c-jun in the epidermis. Mice lacking c-jun in keratinocytes (c-junΔep) develop normal skin but express reduced levels of EGFR in the eyelids, leading to open eyes at birth, as observed in EGFR null mice. Primary keratinocytes from c-junΔep mice proliferate poorly, show increased differentiation, and form prominent cortical actin bundles, most likely because of decreased expression of EGFR and its ligand HB-EGF. In the absence of c-Jun, tumor-prone K5-SOS-F transgenic mice develop smaller papillomas, with reduced expression of EGFR in basal keratinocytes. Thus, using three experimental systems, we show that EGFR and HB-EGF are regulated by c-Jun, which controls eyelid development, keratinocyte proliferation, and skin tumor formation

One Health Education Nexus: enhancing synergy among science-, school-, and teacher education beyond academic silos

IntroductionThe fact that the daily lives of billions of people were affected by the medical, social, and political aspects of the SARS-CoV-2 pandemic shows the need to anchor the understanding of One Health in society. Hence, promoting awareness and deepening the understanding of the interrelation between human health, animal health, and ecosystems must be accomplished through quality education, as advocated by UN Sustainable Development Goal 4. The often-questioned and discussed measures taken by governments to control the global pandemic between 2020 and 2023 can be seen as an opportunity to meet the educational needs of civil society solutions in multi-stakeholder settings between public, universities, and schools.MethodsThis paper focuses on the integration of One Health principles in educational frameworks, particularly within the context of the higher education teaching framework “Teaching Clinic.” This master-level course in the domain of pre-service teacher education serves as a potent vehicle for facilitating One Health Education, bridging the gap between research, higher education, and schools. Through the presentation of two case studies, this article demonstrates how the Teaching Clinic approach fosters interdisciplinary perspectives and provides a dynamic learning environment for pre-service teachers, as well as for pupils involved in the educational process.ResultsIn both cases, the integration of educational One Health school teaching-learning settings effectively enhanced pupils’ understanding of complex topics and engaged them in active learning experiences. Pre-service teachers played a crucial role in developing, implementing, and evaluating these interventions. In Case I, pupils demonstrated proficiency in analyzing data and evaluating mathematical models, while in Case II, the chosen instructional approach facilitated One Health knowledge acquisition and enjoyment among pupils. These results underscore the potential of the One Health Teaching Clinic as a valuable educational framework for enhancing teaching and learning outcomes for pre-service teachers and fostering pupil engagement in socio-scientific One Health-related topics.DiscussionThe discussion delves into the significance of breaking down disciplinary silos and the crucial role of teacher education in promoting a holistic approach to education, emphasizing the intersectionality of One Health Education and Education for Sustainable Development. This article underpins the significance of collaborative efforts across multiple (scientific) disciplines and across secondary and tertiary education levels to reach a nexus. Moreover, it emphasizes the alignment of this approach with the 2030 Agenda, Education for Sustainable Development, and Sustainable Development Goals, highlighting the potential for collective action toward a more sustainable future

„Mehr als nur Bestäubung“ – Schülervorstellungen zur Bestäubungsbiologie und deren Implikationen für den Unterricht

ZUSAMMENFASSUNGDer Prozess der Bestäubung stellt einen wichtigen Abschnitt in der sexuellen Vermehrung höherer Pflanzen dar und ist auch essentiell für das Verständnis der Vielfalt der Blütenpflanzen. Darüber hinaus wird  der Bestäubungsbiologie aufgrund der aktuellen Diskussionen rund um das Bienensterben eine besondere Aktualität beigemessen. Eine Erforschung der Schülervorstellungen zu diesem Thema ist somit von großem fachdidaktischem Interesse. In der vorliegenden qualitativen Studie wurden deshalb Schülervorstellungen von sieben Schüler_innen der 5. Schulstufe zur Bestäubungsbiologie mithilfe von leitfadenorientierten Interviews erhoben und in einer qualitativen Inhaltsanalyse ausgewertet. Die Ergebnisse zeigen, dass Lernende nur mangelhaft zwischen Bestäubung und Samenausbreitung unterscheiden und Bestäu-bung häufig als beabsichtigte Handlung der Insekten sehen. Außerdem zeigen die Vorstellungen über den Zusammenhang von Blüten und Besuchern, dass bereits zu Beginn der 5. Schulstufe Vorstellungen zu Anpassung und Angepasstheit vorhanden sind, die im Unterricht zur Evolution berücksichtigt werden müssen. Diese erhobenen Schülervorstellungen werden mit der fachlichen Perspektive in Beziehung gesetzt und daraus ableitbare fachdidaktische Implikationen diskutiert.ABSTRACTThe process of pollination plays a major role in the lifecycle of plants and is important for understanding the variety of flowering plants. Pollination is also a current issue due to the colony collapse disorder of honeybees. Therefore, investigating students’ conceptions about pollination is highly relevant. The present study investigates conceptions of seven students from 5th grade using guided interviews with regard to pollination biology. Results show that students have serious difficulties differentiating between pollination and seed dispersal. Furthermore, there are differences between students’ conceptions and scientific con-ceptions as students often see pollination as a deliberate act of insects. Students’ conceptions about adaptations of flowers and their pollinators indicate that students’ from 5th grade use evolutionary conceptions which have to be considered when teaching evolution. Students’ conceptions will be discussed in relation to the scientific perspective to derive implications for teaching

EuroScitizen Working Group 2 I Identifying needs and opportunities to improve the contribution of formal education to public literacy on evolution

EuroScitizen is a COST Action and involves a research network whose aim is to identify strategies to raise levels of scientific literacy about evolution in Europe. EuroScitizen comprises five working groups (WG) and this poster summarizes the current achievements of WG2 on formal education. WG2 aims to identify the needs and opportunities to improve the teaching of evolution since the first school years in distinct countries and enhance the contribution of formal education to European public scientific literacy on this important topic. To achieve these objectives we are studying: i) the school curricula and ii) textbooks of the participating countries; iii) teachers’ content knowledge, pedagogical content knowledge, attitudes and beliefs about teaching evolution and effective methodologies and strategies to empower teachers about evolution education; and iv) strategies to promote evolution understanding in elementary school students. This poster presents some of the current achievements of WG2, such as: i) publication of a paper about the development and validation of a framework for the assessment of school curricula on the presence of evolutionary concepts (FACE); ii) comparison of the content of most adopted textbooks in the schools of 8 countries, from the 1st to the 9th grade, about the presence of evolution Big Ideas; iii) identification of teachers’ best practices in evolution education and teacher’ training actions about evolution education; and iv) the publication of a study about the evolutionary concepts that elementary school students most often used after a pedagogical intervention. The next steps of the WG2 are also presented.info:eu-repo/semantics/publishedVersio

Forum Studienreform

Das Studienreform-Forum ist eine Initiative von Physik-Studierenden aus verschiedenen Teilen des deutschsprachigen Raumes, das erstmalig im Rahmen der DPG-Frühjahrstagung 2019 des Fachverbandes Didaktiken in Aachen stattfand und hier dokumentiert wird

Forum Studienreform

Das Studienreform-Forum ist eine Initiative von Physik-Studierenden aus verschiedenen Teilen des deutschsprachigen Raumes, das erstmalig im Rahmen der DPG-Frühjahrstagung 2019 des Fachverbandes Didaktiken in Aachen stattfand und hier dokumentiert wird

Animal Welfare Attitudes: Effects of Gender and Diet in University Samples from 22 Countries

Animal Welfare Attitudes (AWA) are defined as human attitudes towards the welfare of animals in different dimensions and settings. Demographic factors, such as age and gender are associated with AWA. The aim of this study was to assess gender differences among university students in a large convenience sample from twenty-two nations in AWA. A total of 7914 people participated in the study (5155 women, 2711 men, 48 diverse). Participants completed a questionnaire that collected demographic data, typical diet and responses to the Composite Respect for Animals Scale Short version (CRAS-S). In addition, we used a measure of gender empowerment from the Human Development Report. The largest variance in AWA was explained by diet, followed by country and gender. In terms of diet, 6385 participants reported to be omnivores, 296 as pescatarian, 637 ate a vegetarian diet and 434 were vegans (n = 162 without answer). Diet was related with CRAS-S scores; people with a vegan diet scored higher in AWA than omnivores. Women scored significantly higher on AWA than men. Furthermore, gender differences in AWA increased as gender inequality decreased

Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks

A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Search for black holes and other new phenomena in high-multiplicity final states in proton-proton collisions at root s=13 TeV

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