Le bailliage de l'eau à Arnemude au Moyen Age

Scherft P. Le bailliage de l'eau à Arnemude au Moyen Age. In: Revue du Nord, tome 57, n°224, Janvier-mars 1975. p. 109

Le bailliage de l'eau à Arnemude au Moyen Age

Scherft P. Le bailliage de l'eau à Arnemude au Moyen Age. In: Revue du Nord, tome 57, n°224, Janvier-mars 1975. p. 109

Het sterfhuis van Willem van Oranje /

Diss. doct

Morphologic features of bone in human osteopetrosis

Trabecular bone biopsies obtained from six patients with malignant osteopetrosis, one patient with benign osteopetrosis, and two controls were examined by light and electron microscopy. Osteopetrotic osteoclasts showed little to no signs of active involvement in bone resorption. Ruffled borders and clear zones were absent in most cells. In all patients there were large numbers of osteoclasts. Numbers of osteoblasts, bone lining cells, and bone marrow stromal cells were extremely low in all patients with malignant osteopetrosis. In six of the patients a mineralized layer of amorphous organic material lacking collagen fibrils was seen covering large areas of the bone or cartilage matrix. We suggest that this layer represents a pathological calcification on which subsequently organic material has accumulated. The abnormalities in osteopetrotic bone are discussed in the light of the pathogenesis of this diseas