A Time-Variant Value-Focused Methodology for Supporting Pre-Acquisition

Military operations are dynamic in nature, as time-dependent requirements or adversary actions can contribute to differing levels of mission performance among systems. Future military operations commonly use multi-criteria decision analysis techniques that rely on value-focused thinking (VFT) to analyze and ultimately rank alternatives during the Analysis of Alternatives phase of the acquisition process. Traditional VFT approaches are not typically employed with the intention of analyzing time-variant performance of alternatives. In this research, a holistic approach towards integrating fundamental practices such as VFT, systems architecture, and modeling and simulation is used to analyze time-dependent data outputs of an alternative’s performance within an operational environment. Incorporating this approach prior to Milestone A of the acquisition process allows for the identification of time-based capability gaps and additional dynamic analysis of possible alternatives that can be implemented as a flexible means of assessment. As part of this research, the pre-acquisition methodology is implemented with a hypothetical multi-domain Intelligence, Surveillance, and Reconnaissance mission in order to exemplify multiple time-dependent analysis possibilities

The Effect of Varying Levels of Depressive Symptoms on Mindfulness Acquisition: An Exploratory Study

Research and clinical theory increasingly suggest that mindfulness may be an effective clinical intervention for a myriad of mental illnesses. However, there is debate in the field as to whether or not mindfulness-based programs may be beneficial for treatment of active depression. Those cautioning against the use of mindfulness-based programs suggest that the cognitive demands of a meditation practice may be too difficult for those with acute depressive symptoms. The purpose of this study is to investigate whether differences exist between individuals with varying levels of depressive symptoms in the ability to acquire mindfulness skills. Data comes from a two-week, longitudinal study in which undergraduates, with a range of depressive symptoms, engaged in a breath-focused mindfulness exercise every other day. Self-reported trait mindfulness, state mindfulness, depressive symptoms, rumination, and sleep quality were measured at various time points over the two-week study period. Multilevel modeling was used for main analyses. Results suggest individuals with more acute, depressive symptoms may be able to successfully acquire trait mindfulness skills, as well as receive an adjunctive benefit such as a reduction in depressive symptoms over time, and reduced rumination and increased sleep quality. Limitations and future directions are addressed

Now or Later: A Simple Policy for Effective Dual Sourcing in Capacitated Systems

We examine a possibly capacitated, periodically reviewed, single-stage inventory system where replenishment can be obtained either through a regular fixed lead time channel, or, for a premium, via a channel with a smaller fixed lead time. We consider the case when the unsatisfied demands are backordered over an infinite horizon, introducing the easily implementable, yet informationally rich dual-index policy. We show very general separability results for the optimal parameter values, providing a simulation-based optimization procedure that exploits these separability properties to calculate the optimal inventory parameters within seconds. We explore the performance of the dual-index policy under stationary demands as well as capacitated production environments, demonstrating when the dual-sourcing option is most valuable. We find that the optimal dual-index policy mimics the behavior of the complex, globally optimal state-dependent policy found via dynamic programming: the dual-index policy is nearly optimal (within 1% or 2%) for the majority of cases, and significantly outperforms single sourcing (up to 50% better). Our results on optimal dual-index parameters are generic, extending to a variety of complex and realistic scenarios such as nonstationary demand, random yields, demand spikes, and supply disruptions

Cystein-Mutanten der Cu,Zn-Superoxiddismutase und ihre Anwendung in Proteinelektroden für die Detektion von freien Sauerstoffradikalen

Das Enzym Superoxiddismutase (SOD) bietet wegen seiner hohen Reaktionsrate und seiner extrem hohen Substratspezifi tät große Vorteile für eine Anwendung als Superoxidbiosensor. In dieser Arbeit wurden durch molekularbiologische Methoden Mutanten der humanen Cu,Zn-SOD gewonnen, welche ein oder zwei zusätzliche Cystein-Reste enthielten, die eine einfache Immobilisierung des Proteins durch Bindung des Cystein-Schwefels auf Goldelektroden ermöglichten. Sechs solcher Mutanten wurden entworfen, exprimiert, aufgereinigt und elektrochemisch charakterisiert. Alle Mutanten konnten durch einen einfachen Inkubationsschritt auf Goldelektroden gebunden werden und zeigten ein quasi-reversibles elektrochemisches Ansprechen. Für eine Mutante wurde die Anwendung als Superoxidsensor genauer untersucht und für beide Teilreaktionen der Dismutation ein Ansprechen des Sensors auf das Radikal gefunden. Bei Verwendung einer Teilreaktion konnte die Empfindlichkeit herkömmlicher Monoschichtsensoren um etwa eine Größenordnung übertroffen werden

Image Analysis to Determine Intramuscular Fat in Muscle

The area of intramuscular fat in Holstein steer longissimus was determined using an image analyzing system. Slaughter weights of 500, 636 and 773 kg differed (p \u3c 0.05) for intramuscular fat area, marbling score, and ether extractable lipid . Repeated measurements of intramuscular fat area in a given section showed high accuracy . However, comparing two sections from the same sample, there was often a large difference in fat content between the sections. Fat content determined by the imaging system was correlated significantl y with marbling score (r = 0.49) and ether extractable lipid (r = 0.34). Sampling is critical, and in order to obtain a high correlation several samples would be required from each muscle

Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance

Progression and disease relapse of chronic myeloid leukemia (CML) depends on leukemia-initiating cells (LIC) that resist treatment. Using mouse genetics and a BCR-ABL model of CML, we observed cross talk between Wnt/{beta}-catenin signaling and the interferon-regulatory factor 8 (Irf8). In normal hematopoiesis, activation of {beta}-catenin results in up-regulation of Irf8, which in turn limits oncogenic {beta}-catenin functions. Self-renewal and myeloproliferation become dependent on {beta}-catenin in Irf8-deficient animals that develop a CML-like disease. Combined Irf8 deletion and constitutive {beta}-catenin activation result in progression of CML into fatal blast crisis, elevated leukemic potential of BCR-ABL-induced LICs, and Imatinib resistance. Interestingly, activated {beta}-catenin enhances a preexisting Irf8-deficient gene signature, identifying {beta}-catenin as an amplifier of progression-specific gene regulation in the shift of CML to blast crisis. Collectively, our data uncover Irf8 as a roadblock for {beta}-catenin-driven leukemia and imply both factors as targets in combinatorial therapy

Late‐ but not early‐onset blindness impairs the development of audio‐haptic multisensory integration

Integrating different senses to reduce sensory uncertainty and increase perceptual precision can have an important compensatory function for individuals with visual impairment and blindness. However, how visual impairment and blindness impact the development of optimal multisensory integration in the remaining senses is currently unknown. Here we first examined how audio‐haptic integration develops and changes across the life span in 92 sighted (blindfolded) individuals between 7 to 70 years of age. We used a child‐ friendly task in which participants had to discriminate different object sizes by touching them and/or listening to them. We assessed whether audio‐haptic performance resulted in a reduction of perceptual uncertainty compared to auditory‐only and haptic‐only performance as predicted by maximum‐likelihood estimation model. We then compared how this ability develops in 28 children and adults with different levels of visual experience, focussing on low‐vision individuals and blind individuals that lost their sight at different ages during development. Our results show that in sighted individuals, adult‐like audio‐haptic integration develops around 13‐15 years of age, and remains stable until late adulthood. While early‐blind individuals, even at the youngest ages, integrate audio‐haptic information in an optimal fashion, late‐blind individuals do not. Optimal integration in low‐vision individuals follows a similar developmental trajectory as that of sighted individuals. These findings demonstrate that visual experience is not necessary for optimal audio‐haptic integration to emerge, but that consistency of sensory information across development is key for the functional outcome of optimal multisensory integration