Constraints on extra dimensions from precision molecular spectroscopy

Accurate investigations of quantum level energies in molecular systems are shown to provide a test ground to constrain the size of compactified extra dimensions. This is made possible by the recent progress in precision metrology with ultrastable lasers on energy levels in neutral molecular hydrogen (H$_2$, HD and D$_2$) and the molecular hydrogen ions (H$_2^+$, HD$^+$ and D$_2^+$). Comparisons between experiment and quantum electrodynamics calculations for these molecular systems can be interpreted in terms of probing large extra dimensions, under which conditions gravity will become much stronger. Molecules are a probe of space-time geometry at typical distances where chemical bonds are effective, i.e. at length scales of an \AA. Constraints on compactification radii for extra dimensions are derived within the Arkani-Hamed-Dimopoulos-Dvali framework, while constraints for curvature or brane separation are derived within the Randall-Sundrum framework. Based on the molecular spectroscopy of D$_2$ molecules and HD$^+$ ions, the compactification size for seven extra dimensions (in connection to M-theory defined in 11 dimensions) of equal size is shown to be limited to $R_7 < 0.6 \mu$m. While limits on compactification sizes of extra dimensions based on other branches of physics are compared, the prospect of further tightening constraints from the molecular method is discussed

Transformations among large c conformal field theories

We show that there is a set of transformations that relates all of the 24 dimensional even self-dual (Niemeier) lattices, and also leads to non-lattice objects that however cannot be interpreted as a basis for the construction of holomorphic conformal field theory. In the second part of this paper, we extend our observations to higher dimensional conformal field theories build on extremal partition functions, where we generate c=24k theories with spectra decomposable into the irreducible representations of the Fischer-Griess Monster. We observe interesting periodicities in the coefficients of extremal partition functions and characters of the extremal vertex operator algebras.Comment: 14 pages, minor corrections, new references adde

Interferons, properties and applications

The main theme of this thesis is the clinical evaluation of interferon. From the biology of the interferon system and animal experiments it can be expected that exogenous interferon will exert its optimum effect when used to prevent acute infections or to modulate chronic infections. Therefore, we administered interferon to patients with chronic hepatitis B virus infection (chapter 5) and to renal transplant recipients, in whom viral infections occur frequently in the first months after transplantation (chapter 6). The other studies in this thesis are directly related to the problems we met in the clinical studies. We wanted to study interferon in an animal renal transplantation model. For us the most obvious choice was the rat. However, little was known about the production and characterization of rat interferon. Chapter 2 describes our experiences with rat interferon. While we were well underway with the study in renal transplant recipients, we were contacted by Martin Hirsch, who was conducting a similar trial in Boston. Some of his patients receiving 3 x 106 U HLI every other day showed severe bone marrow depression. We had no such problem in our trial, but we used another type of interferon: HFI. For this reason we started a study on the t'oxicity of interferons for bone marrow in vitro

Poincare Polynomials and Level Rank Dualities in the N=2N=2 Coset Construction

We review the coset construction of conformal field theories; the emphasis is on the construction of the Hilbert spaces for these models, especially if fixed points occur. This is applied to the $N=2$ superconformal cosets constructed by Kazama and Suzuki. To calculate heterotic string spectra we reformulate the Gepner con- struction in terms of simple currents and introduce the so-called extended Poincar\'e polynomial. We finally comment on the various equivalences arising between models of this class, which can be expressed as level rank dualities. (Invited talk given at the III. International Conference on Mathematical Physics, String Theory and Quantum Gravity, Alushta, Ukraine, June 1993. To appear in Theor. Math. Phys.)Comment: 14 pages in LaTeX, HD-THEP-93-4

Constraints on extra dimensions from precision molecular spectroscopy

9 págs.; 2 figs.; 2 tabs.; Open Access funded by Creative Commons Atribution Licence 3.0Accurate investigations of quantum-level energies in molecular systems are shown to provide a testing ground to constrain the size of compactified extra dimensions. This is made possible by recent progress in precision metrology with ultrastable lasers on energy levels in neutral molecular hydrogen (H2, HD, and D2) and molecular hydrogen ions (H2+, HD+, and D2+). Comparisons between experiment and quantum electrodynamics calculations for these molecular systems can be interpreted in terms of probing large extra dimensions, under which conditions gravity will become much stronger. Molecules are a probe of spacetime geometry at typical distances where chemical bonds are effective (i.e., at length scales of an Å). Constraints on compactification radii for extra dimensions are derived within the Arkani-Hamed-Dimopoulos-Dvali framework, while constraints for curvature or brane separation are derived within the Randall-Sundrum framework. Based on the molecular spectroscopy of D2 molecules and HD+ ions, the compactification size for seven extra dimensions (in connection to M-theory defined in 11 dimensions) of equal size is shown to be limited to R7 < 0.6 mμ . While limits on compactification sizes of extra dimensions based on other branches of physics are compared, the prospect of further tightening constraints from the molecular method is discussed. © 2015 IOP Publishing Ltd and Deutsche Physikalische GesellschaftThis work was supported by the Netherlands Foundation for Fundamental Research of Matter (FOM) through the program ‘Broken Mirrors & Drifting Constants’. B Gato-Rivera and A N Schellekens have been partially supported by funding from the Spanish Ministerio de Economia y Competitividad, Research Project FIS2012- 38816, and by the Project CONSOLIDER-INGENIO 2010, Programme CPAN (CSD2007-00042).Peer Reviewe

Changes in fMRI BOLD dynamics reflect anticipation to moving objects

The human brain is thought to respond differently to novel versus predictable neural input. In human visual cortex, neural response amplitude to visual input might be determined by the degree of predictability. We investigated how fMRI BOLD responses in human early visual cortex reflect the anticipation of a single moving bar's trajectory. We found that BOLD signals decreased linearly from onset to offset of the stimulus trajectory. Moreover, decreased amplitudes of BOLD responses coincided with an increased initial dip as the stimulus moved along its trajectory. Importantly, motion anticipation effects were absent, when motion coherence was disrupted by means of stimulus contrast reversals. These results show that human early visual cortex anticipates the trajectory of a coherently moving object at the initial stages of visual motion processing. The results can be explained by suppression of predictable input, plausibly underlying the formation of stable visual percepts

Quality of Original and Biosimilar Epoetin Products

# The Author(s) 2010. This article is published with open access at Springerlink.com Purpose To compare the quality of therapeutic erythropoietin (EPO) products, including two biosimilars, with respect to content, aggregation, isoform profile and potency. Methods Two original products, Eprex (epoetin alfa) and Dynepo (epoetin delta), and two biosimilar products, Binocrit (epoetin alfa) and Retacrit (epoetin zeta), were compared using (1) high performance size exclusion chromatography, (2) ELISA, (3) SDS-PAGE, (4) capillary zone electrophoresis and (5) in-vivo potency. Results Tested EPO products differed in content, isoform composition, and potency. Conclusion Of the tested products, the biosimilars have the same or even better quality as the originals. Especially, the potency of originals may significantly differ from the value on the label

The non-compact elliptic genus: mock or modular

We analyze various perspectives on the elliptic genus of non-compact supersymmetric coset conformal field theories with central charge larger than three. We calculate the holomorphic part of the elliptic genus via a free field description of the model, and show that it agrees with algebraic expectations. The holomorphic part of the elliptic genus is directly related to an Appell-Lerch sum and behaves anomalously under modular transformation properties. We analyze the origin of the anomaly by calculating the elliptic genus through a path integral in a coset conformal field theory. The path integral codes both the holomorphic part of the elliptic genus, and a non-holomorphic remainder that finds its origin in the continuous spectrum of the non-compact model. The remainder term can be shown to agree with a function that mathematicians introduced to parameterize the difference between mock theta functions and Jacobi forms. The holomorphic part of the elliptic genus thus has a path integral completion which renders it non-holomorphic and modular.Comment: 13 page

On Heterotic/Type I Duality in d=8

We discuss heterotic corrections to quartic internal U(1) gauge couplings and check duality by calculating one-loop open string diagrams and identifying the D-instanton sum in the dual type I picture. We also compute SO(8)^4 threshold corrections and finally R^2 corrections in type I theory.Comment: 9 pages, Latex, To appear in the proceedings of "Quantum Aspects of Gauge Theories, Supersymmetries and Unification", Corfu, September 199

Theory for a Hanbury Brown Twiss experiment with a ballistically expanding cloud of cold atoms

We have studied one-body and two-body correlation functions in a ballistically expanding, non-interacting atomic cloud in the presence of gravity. We find that the correlation functions are equivalent to those at thermal equilibrium in the trap with an appropriate rescaling of the coordinates. We derive simple expressions for the correlation lengths and give some physical interpretations. Finally a simple model to take into account finite detector resolution is discussed