Transitional States and Psychic Change

One of my favorite scenes in literature occurs in D. H. Lawrence\u27s novel The Rainbow (1915). Tom Brangwen\u27s Polish wife Lydia is upstairs in their home giving birth. Tom is downstairs with Anna, Lydia\u27s four-year-old child by her first marriage. Anna is panic-stricken, screaming in terror for her mother, and Tom is responding to her with irritation and mounting anger. Like the child, he too is feeling shut out and abandoned by Lydia. Tom is made particularly furious by the blind and mechanical nature of Anna\u27s crying

Similarities and differences between the E5 oncoproteins of bovine papillomaviruses type 1 and type 4: Cytoskeleton, motility and invasiveness in E5-transformed bovine and mouse cells

Bovine papillomaviruses (BPVs) are oncogenic viruses. In cattle, BPV-1/2 is associated with urinary bladder cancer and BPV-4 with upper GI tract cancer. BPV E5 is a small hydrophobic protein localised in the endoplasmic reticulum (ER) and Golgi apparatus (GA). E5 is the major transforming protein of BPVs, capable of inducing cell transformation in cultured mouse fibroblasts and, in cooperation with E7, in primary bovine cells. E5-induced cell transformation is accompanied by activation of several cellular protein kinases, including growth factor receptors, and alkalinisation of endosomes and GA. We have reported that BPV E5 causes swelling and fragmentation of the GA and extensive vacuolisation of the cytoplasm. We now show that E5 from both BPV-1 and BPV-4 disturbs the actin cytoskeleton and focal adhesions in transformed bovine cells, where these morphological and behavioural characteristics are accompanied by hyperphosphorylation of the cellular phosphotyrosine kinase c-src. Both BPV-1 and BPV-4 E5 increase the motility of transformed mouse cells, but only BPV-1 E5 causes transformed mouse cells to penetrate a matrigel matrix. BPV-1 transformed mouse cells, but not BPV-4 transformed mouse cells, have hyperhpsphorylated c-src

Transitional States and Psychic Change

One of my favorite scenes in literature occurs in D. H. Lawrence\u27s novel The Rainbow (1915). Tom Brangwen\u27s Polish wife Lydia is upstairs in their home giving birth. Tom is downstairs with Anna, Lydia\u27s four-year-old child by her first marriage. Anna is panic-stricken, screaming in terror for her mother, and Tom is responding to her with irritation and mounting anger. Like the child, he too is feeling shut out and abandoned by Lydia. Tom is made particularly furious by the blind and mechanical nature of Anna\u27s crying

Trauma and Sadomasochistic Narrative

This essay applies trauma theory and relational psychoanalysis to a close reading of Mary Gaitskill\u27s short story The Dentist. It argues that the sadomasochistic relationship central to this story, and to much of Gaitskill\u27s fiction, is rooted in trauma and can be illuminated by an understanding of the post-traumatic condition

Psychoanalysis and the Problem of Evil

Since evil has become a term much in vogue in our current political climate, it seems ever more important to explore its psychic meanings and origins. What, first of all, do analysts and therapists mean by the word evil ? The grandiosity of the term, as well as its traditionally religious connotations, perhaps make it unsuited to the therapeutic context. As Ruth Stein (2002) has commented, Evil\u27 may sound too allegorical or too concrete, too essentialist or too objective for psychoanalytic ways of thinking that are oriented towards the study of individual subjectivity (394)

Stories Within Stories: A Passion for Reading Psychoanalytically

https://digitalcommons.ric.edu/av_root/1072/thumbnail.jp

D.H. Lawrence and the paradoxes of psychic life /

Includes bibliographical references (p. 143-149) and index