Performance Evaluation for Cost-Efficient Public Infrastructure Cloud Use

In this paper, we discuss the nature of variability in compute performance in Infrastructure Clouds and how this presents opportunities for Cloud Service Brokers (CSB) in relation to pricing. Performance variation in virtual machines of the same type and price raises specific issues for end users: (i) the time taken to complete a task varies with performance, and therefore costs also vary (ii) the number of instances required to meet a certain problem scale within a given time being variable, so costs depend on variations in scale needed to meet the requirement; (iii) different computational requirements are better satisfied by different hardware, and understanding the relationship between instance types and available resources implies further costs. We demonstrate such variability problems empirically in a Public Infrastructure Cloud, and use the data gathered to discuss performance price issues, and how a CSB may re-price instances based on their performance

Word frequency in fast priming: Evidence for immediate cognitive control of eye movements during reading

Numerous studies have demonstrated effects of word frequency on eye movements during reading, but the precise timing of this influence has remained unclear. The fast priming paradigm (Sereno & Rayner, 1992) was previously used to study influences of related versus unrelated primes on the target word. Here, we used this procedure to investigate whether the frequency of the prime word has a direct influence on eye movements during reading when the prime-target relation is not manipulated. We found that with average prime intervals of 32 ms readers made longer single fixation durations on the target word in the low than in the high frequency prime condition. Distributional analyses demonstrated that the effect of prime frequency on single fixation durations occurred very early, supporting theories of immediate cognitive control of eye movements. Finding prime frequency effects only 207 ms after visibility of the prime and for prime durations of 32 ms yields new time constraints for cognitive processes controlling eye movements during reading. Our variant of the fast priming paradigm provides a new approach to test early influences of word processing on eye movement control during reading

Observation of magnetic vortex pairs at room temperature in a planar {\alpha}-Fe2O3/Co heterostructure

Vortices are among the simplest topological structures, and occur whenever a flow field `whirls' around a one-dimensional core. They are ubiquitous to many branches of physics, from fluid dynamics to superconductivity and superfluidity, and are even predicted by some unified theories of particle interactions, where they might explain some of the largest-scale structures seen in today's Universe. In the crystalline state, vortex formation is rare, since it is generally hampered by long-range interactions: in ferroic materials (ferromagnetic and ferroelectric), vortices are only observed when the effects of the dipole-dipole interaction is modified by confinement at the nanoscale, or when the parameter associated with the vorticity does not couple directly with strain. Here, we present the discovery of a novel form of vortices in antiferromagnetic (AFM) hematite ($\alpha$-Fe$_2$O$_3$) epitaxial films, in which the primary whirling parameter is the staggered magnetisation. Remarkably, ferromagnetic (FM) topological objects with the same vorticity and winding number of the $\alpha$-Fe$_2$O$_3$ vortices are imprinted onto an ultra-thin Co ferromagnetic over-layer by interfacial exchange. Our data suggest that the ferromagnetic vortices may be merons (half-skyrmions, carrying an out-of-plane core magnetisation), and indicate that the vortex/meron pairs can be manipulated by the application of an in-plane magnetic field, H$_{\parallel}$, giving rise to large-scale vortex-antivortex annihilation.Comment: 16 pages, 4 figure

Coronagraphic observations of Si X 1430 nm acquired by DKIST/Cryo-NIRSP with methods for telluric absorption correction

We report commissioning observations of the Si X 1430 nm solar coronal line observed coronagraphically with the Cryogenic Near-Infrared Spectropolarimeter (Cryo-NIRSP) at the National Science Foundation's Daniel K. Inouye Solar Telescope (DKIST). These are the first known spatially resolved observations of this spectral line, which has strong potential as a coronal magnetic field diagnostic. The observations target a complex active region located on the solar northeast limb on 4 March 2022. We present a first analysis of this data, which extracts the spectral line properties through a careful treatment of the variable atmospheric transmission that is known to impact this spectral window. Rastered images are created and compared with EUV observations from the SDO/AIA instrument. A method for estimating the electron density from the Si X observations is then demonstrated that makes use of the forbidden line's density-sensitive emissivity and an emission-measure analysis of the SDO/AIA bandpass observations. In addition, we derive an effective temperature and non-thermal line width across the region. This study informs the calibration approaches required for more routine observations of this promising diagnostic line.Comment: 12 pages, 9 figures, Accepted for publication in Ap

DKIST unveils the serpentine topology of quiet Sun magnetism in the photosphere

We present the first quiet Sun spectropolarimetric observations obtained with the Visible SpectroPolarimeter (ViSP) at the $4-$m Daniel K. Inouye Solar Telescope (DKIST). We recorded observations in a wavelength range that includes the magnetically sensitive Fe I $6301.5/6302.5$ $\AA$ doublet. With an estimated spatial resolution of 0.08'', this represents the highest spatial resolution full-vector spectropolarimetric observations ever obtained of the quiet Sun. We identified $53$ small-scale magnetic elements, including $47$ magnetic loops and $4$ unipolar magnetic patches, with linear and circular polarisation detected in all of them. Of particular interest is a magnetic element in which the polarity of the magnetic vector appears to change three times in only $400$ km and which has linear polarisation signals throughout. We find complex Stokes $V$ profiles at the polarity inversion lines of magnetic loops and discover degenerate solutions, as we are unable to conclusively determine whether these arise due to gradients in the atmospheric parameters or smearing of opposite polarity signals. We analyse a granule which notably has linear and circular polarisation signals throughout, providing an opportunity to explore its magnetic properties. On this small scale we see the magnetic field strength range from $25$ G at the granular boundary to $2$ kG in the intergranular lane (IGL), and sanity check the values with the weak and strong field approximations. A value of $2$ kG in the IGL is among the highest measurements ever recorded for the internetwork.Comment: Accepted for publication in ApJ

impulsivity and the impact of contextual cues on instrumental behavior in alcohol dependence

Alcohol-related cues acquire incentive salience through Pavlovian conditioning and then can markedly affect instrumental behavior of alcohol-dependent patients to promote relapse. However, it is unclear whether similar effects occur with alcohol-unrelated cues. We tested 116 early-abstinent alcohol- dependent patients and 91 healthy controls who completed a delay discounting task to assess choice impulsivity, and a Pavlovian-to-instrumental transfer (PIT) paradigm employing both alcohol-unrelated and alcohol-related stimuli. To modify instrumental choice behavior, we tiled the background of the computer screen either with conditioned stimuli (CS) previously generated by pairing abstract pictures with pictures indicating monetary gains or losses, or with pictures displaying alcohol or water beverages. CS paired to money gains and losses affected instrumental choices differently. This PIT effect was significantly more pronounced in patients compared to controls, and the group difference was mainly driven by highly impulsive patients. The PIT effect was particularly strong in trials in which the instrumental stimulus required inhibition of instrumental response behavior and the background CS was associated to monetary gains. Under that condition, patients performed inappropriate approach behavior, contrary to their previously formed behavioral intention. Surprisingly, the effect of alcohol and water pictures as background stimuli resembled that of aversive and appetitive CS, respectively. These findings suggest that positively valenced background CS can provoke dysfunctional instrumental approach behavior in impulsive alcohol- dependent patients. Consequently, in real life they might be easily seduced by environmental cues to engage in actions thwarting their long-term goals. Such behaviors may include, but are not limited to, approaching alcohol

Chronicity in Strongyloides stercoralis infections: dichotomy of the protective immune response to infective and autoinfective larvae in a mouse model.

Strongyloidiasis is an intestinal disease that can last for decades due to the occurrence of autoinfective larvae (L3a) in an infected person, which contribute to the maintenance of the population of adult worms in the intestine. The goal of the present study was to determine if L3a are susceptible to the protective immunity that targets the infective stage of the worm, the third-stage larvae (L3). Mice immunized and challenged with Strongyloides stercoralis L3 kill more than 90% of challenge larvae contained within diffusion chambers. The L3 do not remain antigenically static in mice, however, but undergo some degree of antigenic change before they are killed, becoming host-activated larvae (L3+). The L3/L3+ are killed in this model system by the combined effects of both parasite-specific IgM and eosinophils. Mice immunized with L3 were able to kill L3/L3+, but did not kill L3a, in challenge infections. Eosinophils were, however, present in diffusion chambers containing L3a, and IgM bound to the surface of L3a. We hypothesized that differential IgM recognition of soluble L3a, L3, and L3+ antigens is the reason why the immune response generated against L3 could not kill L3a. Many common antigens on L3, L3+, and L3a were recognized by serum from mice immunized with L3, as determined by immunoblotting. However, several unique L3, L3+, and L3a antigens were also recognized by immune serum, thus indicating that antigen recognition with IgM antibodies is different between the L3, L3+, and L3a stages. This difference in antigen recognition could explain why L3a are able to evade the immune response that targets L3/L3+ in chronically infected hosts

Exploiting Parallel R in the Cloud with SPRINT

BACKGROUND: Advances in DNA Microarray devices and next-generation massively parallel DNA sequencing platforms have led to an exponential growth in data availability but the arising opportunities require adequate computing resources. High Performance Computing (HPC) in the Cloud offers an affordable way of meeting this need. OBJECTIVES: Bioconductor, a popular tool for high-throughput genomic data analysis, is distributed as add-on modules for the R statistical programming language but R has no native capabilities for exploiting multi-processor architectures. SPRINT is an R package that enables easy access to HPC for genomics researchers. This paper investigates: setting up and running SPRINT-enabled genomic analyses on Amazon’s Elastic Compute Cloud (EC2), the advantages of submitting applications to EC2 from different parts of the world and, if resource underutilization can improve application performance. METHODS: The SPRINT parallel implementations of correlation, permutation testing, partitioning around medoids and the multi-purpose papply have been benchmarked on data sets of various size on Amazon EC2. Jobs have been submitted from both the UK and Thailand to investigate monetary differences. RESULTS: It is possible to obtain good, scalable performance but the level of improvement is dependent upon the nature of algorithm. Resource underutilization can further improve the time to result. End-user’s location impacts on costs due to factors such as local taxation. Conclusions: Although not designed to satisfy HPC requirements, Amazon EC2 and cloud computing in general provides an interesting alternative and provides new possibilities for smaller organisations with limited funds

Insight into the solar plage chromosphere with DKIST

The strongly coupled hydrodynamic, magnetic, and radiation properties of the plasma in the solar chromosphere makes it a region of the Sun's atmosphere that is poorly understood. We use data obtained with the high-resolution Visible Broadband Imager (VBI) equipped with an H$\beta$ filter and the Visible Spectro-Polarimeter (ViSP) at the Daniel K. Inouye Solar Telescope to investigate the fine-scale structure of the plage chromosphere. To aid the interpretation of the VBI imaging data, we also analyze spectra from the CHROMospheric Imaging Spectrometer on the Swedish Solar Telescope. The analysis of spectral properties, such as enhanced line widths and line depths explains the high contrast of the fibrils relative to the background atmosphere demonstrating that H$\beta$ is an excellent diagnostic for the enigmatic fine-scale structure of the chromosphere. A correlation between the parameters of the H$\beta$ line indicates that opacity broadening created by overdense fibrils could be the main reason for the spectral line broadening observed frequently in chromospheric fine-scale structures. Spectropolarimetric inversions of the ViSP data in the Ca II 8542 {\AA} and Fe I 6301/6302 {\AA} lines are used to construct semiempirical models of the plage atmosphere. Inversion outputs indicate the existence of dense fibrils in the Ca II 8542 {\AA} line. The analyses of the ViSP data show that the morphological characteristics, such as orientation, inclination and length of fibrils are defined by the topology of the magnetic field in the photosphere. Chromospheric maps reveal a prominent magnetic canopy in the area where fibrils are directed towards the observer.Comment: 17 pages, 11 figures, accepted in Ap