Dentin Regeneration

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66570/2/10.1177_08959374950090030501.pd

Методы повышения эффективности работы газотурбинных установок

Объект исследования: газотурбинная установка. Цель работы: аналитический обзор современных направлений повышения эффективности работы ГТУ, сравнительный расчет простой и регенеративной ГТУ при заданных равных условиях. Для достижения поставленной цели рассмотрены следующие задачи: проведение литературного обзора современных направлений повышения эффективности работы газотурбинных установок; сравнительный тепловой расчет простой и регенеративной ГТУ при заданных равных условиях; Определение сметной стоимости работ по монтажу регенератора; анализ вредныхThe object of the study: gas turbine plant. The purpose of the work: analytical review of modern directions of increasing the efficiency of GTP operation, comparative calculation of simple and regenerative GTP under given equal conditions. To achieve this goal, the following tasks are considered: conducting a literature review of modern technologies to increase the efficiency of gas turbine plants; comparative heat calculation of simple and regenerative gas turbine plant (efficiency, specific fuel consumption, heat rate) for given equal conditions; determination of the estimated cost of

HSV Infection Induces Production of ROS, which Potentiate Signaling from Pattern Recognition Receptors: Role for S-glutathionylation of TRAF3 and 6

The innate immune response constitutes the first line of defense against infections. Pattern recognition receptors recognize pathogen structures and trigger intracellular signaling pathways leading to cytokine and chemokine expression. Reactive oxygen species (ROS) are emerging as an important regulator of some of these pathways. ROS directly interact with signaling components or induce other post-translational modifications such as S-glutathionylation, thereby altering target function. Applying live microscopy, we have demonstrated that herpes simplex virus (HSV) infection induces early production of ROS that are required for the activation of NF-κB and IRF-3 pathways and the production of type I IFNs and ISGs. All the known receptors involved in the recognition of HSV were shown to be dependent on the cellular redox levels for successful signaling. In addition, we provide biochemical evidence suggesting S-glutathionylation of TRAF family proteins to be important. In particular, by performing mutational studies we show that S-glutathionylation of a conserved cysteine residue of TRAF3 and TRAF6 is important for ROS-dependent activation of innate immune pathways. In conclusion, these findings demonstrate that ROS are essential for effective activation of signaling pathways leading to a successful innate immune response against HSV infection

Sulforaphane induces neurovascular protection against a systemic inflammatory challenge via both Nrf2-dependent and independent pathways

NIH/NHLBI; German Research Foundation

Understanding and responding to prescribing patterns of sodium valproate-containing medicines in pregnant women and women of childbearing age in Western Cape, South Africa

Growing evidence of the teratogenic potential of sodium valproate (VPA) has changed prescribing practices across the globe; however, the impact of this research and the consequent dissemination of a Dear Health Care Professional Letter (DHCPL) in December 2015, recommending avoidance of the teratogen VPA in women of childbearing age (WOCBA) and pregnant women in South Africa, is unknown. We explored trends and reasons for VPA use among pregnant women and WOCBA in the public sector in Western Cape Province from 1 January 2015 to 31 December 2017. Methods: Using the provincial health information exchange that collates routine electronic health data via unique patient identifiers, we analysed clinical and pharmacy records from 2015 to 2017 to determine prescription patterns of VPA and other antiepileptic drug (AED) and mood-stabilising medicine (MSM) use in WOCBA and pregnant women. Senior clinicians and policy makers were consulted to understand the determinants of VPA use. Results: At least one VPA prescription was dispensed to between 8205 (0.79%) and 9425 (0.94%) WOBCA from a cohort of approximately 1 million WOCBA attending provincial health care facilities per year