Agate Outcomes Analysis: Using the Foundation for SATS

This study explored the policy implications of a specific jointly funded government-industry-academic research and development initiative on future planning. The researcher sought to uncover what trends or patterns of the National Aeronautics and Space Administration (NASA) Advanced General Aviation Transport Experiments (AGATE) had a positive affect on the outcomes of the consortium. By identifying these trends, the research may be able to help foster a more practical transition to follow-on programs. AGATE focused on developing innovative cockpit technologies that highlighted safety, affordability, and ease-of-use based in such areas as flight systems and integrated design and manufacturing. A quantitative analytic methodological approach encompassing qualitative data analysis software and the policy research construct was applied to analyze the organizational policy trends through the application of lessons learned from the AGATE program with reference to the current NASA program-the Small Aircraft Transportation System (SATS). Both NASA programs consist of a similar participant pool. By examining the effects of recommendations from previous studies, this analysis illustrated the transitional effects identified through the analysis. This planning framework illustrated the evolution of program and goal structure and the catalytic effect on the aviation industry and product development through increased interaction

Accreditation of Collegiate Aviation’s Distance Education Programs: Now and in the Future

The purpose of this research endeavor is to benchmark and evaluate the accreditation status of aviation distance education programs in the United States. This study examines both the expanding role of distance education as a delivery method for aviation courses as well as the need for establishing standards. The research methods provide data collection through content analysis, literature review, and a survey tool mailed to aviation professionals nationwide. The findings reveal that, in general, most disciplines are either just beginning to approach the subject of distance education accreditation of programs or do not deal with the issue at all. The results of the research reveal a positive interest in distance education and the accreditation process. Further research is recommended to ensure that the accreditation standards and program guidelines fit the needs of distance education and its students

Comparing hierarchies of total functionals

In this paper we consider two hierarchies of hereditarily total and continuous functionals over the reals based on one extensional and one intensional representation of real numbers, and we discuss under which asumptions these hierarchies coincide. This coincidense problem is equivalent to a statement about the topology of the Kleene-Kreisel continuous functionals. As a tool of independent interest, we show that the Kleene-Kreisel functionals may be embedded into both these hierarchies.Comment: 28 page

Journal of Air Transportation, Volume 10, No. 1

The mission of the Journal of Air Transportation (JA is to provide the global community immediate key resource information in all areas of air transportation. The goal of the Journal is to be recognized as the preeminent scholarly journal in the aeronautical aspects of transportation. As an international and interdisciplinary journal, the JAT will provide a forum for peer-reviewed articles in all areas of aviation and space transportation research, policy, theory, case study, practice, and issues. While maintaining a broad scope, a focal point of the journal will be in the area of aviation administration and policy

An extracellular transglutaminase is required for apple pollen tube growth

An extracellular form of the calcium-dependent protein-crosslinking enzyme TGase (transglutaminase) was demonstrated to be involved in the apical growth of Malus domestica pollen tube. Apple pollen TGase and its substrates were co-localized within aggregates on the pollen tube surface, as determined by indirect immunofluorescence staining and the in situ cross-linking of fluorescently labelled substrates. TGase-specific inhibitors and an anti-TGase monoclonal antibody blocked pollen tube growth, whereas incorporation of a recombinant fluorescent mammalian TGase substrate (histidine-tagged green fluorescent protein:His6– Xpr–GFP) into the growing tube wall enhanced tube length and germination, consistent with a role of TGase as a modulator of cell wall building and strengthening. The secreted pollen TGase catalysed the cross-linking of both PAs (polyamines) into proteins (released by the pollen tube) and His6-Xpr-GFP into endogenous or exogenously added substrates. A similar distribution of TGase activitywas observed in planta on pollen tubes germinating inside the style, consistent with a possible additional role for TGase in the interaction between the pollen tube and the style during fertilization

Wurtzite nanowires strain control by DC electrical stimulation

Nanomechanics is a highly developed area of research, given the significant reported changes in material properties at the nanometer scale, requiring the development of new theories to explain the underlying mechanisms. Such theories must be based on measurements that are as accurate as possible, but unfortunately, conventional experimental techniques do not apply to such small components. Here we present a unique new method to control electro-mechanical forces on quasi −1D nanostructures through static electric fields with multiple ways of control of GaAs nanowires’ strain directly on the growth substrate

Carnobacterium spp. in seafood packaged in modified atmosphere

The composition of lactic acid population in five kinds of seafood (salmon,tuna, shrimps, swordfish and cuttlefish) packaged in two different modified atmospheres,MAP1 (80 O2/20 N2) and MAP2 (40 CO2/60 N2), at 4 \ub0C for 6 days was investigated. The isolates were heterofermentative rods belonging to Carnobacterium, Lactobacillus, and cocci of the Leuconostoc genus. The determination of phenotypical characters and a new polymerase chain reaction primer were used to distinguish Carnobacterium from Lactobacillus. The microorganisms found varied with the kind of seafood and the gas composition of the modified atmospheres: in MAP1, richer of oxygen than MAP2, Carnobacterium spp. represents the prevalent microbial group, especially in tuna, shrimps and swordfish, whereas MAP2 seems to favour Lactobacillus spp. Cocci, belonging to Leuconostoc spp., were dominant in salmon and cuttlefish independently of gas composition

Proteomic profiling reveals the transglutaminase-2 externalization pathway in kidneys after unilateral ureteric obstruction

Increased export of transglutaminase-2 (TG2) by tubular epithelial cells (TECs) into the surrounding interstitium modifies the extracellular homeostatic balance, leading to fibrotic membrane expansion. Although silencing of extracellular TG2 ameliorates progressive kidney scarring in animal models of CKD, the pathway through which TG2 is secreted from TECs and contributes to disease progression has not been elucidated. In this study, we developed a global proteomic approach to identify binding partners of TG2 responsible for TG2 externalization in kidneys subjected to unilateral ureteric obstruction (UUO) using TG2 knockout kidneys as negative controls. We report a robust and unbiased analysis of the membrane interactome of TG2 in fibrotic kidneys relative to the entire proteome after UUO, detected by SWATH mass spectrometry. The data have been deposited to the ProteomeXchange with identifier PXD008173. Clusters of exosomal proteins in the TG2 interactome supported the hypothesis that TG2 is secreted by extracellular membrane vesicles during fibrosis progression. In established TEC lines, we found TG2 in vesicles of both endosomal (exosomes) and plasma membrane origin (microvesicles/ectosomes), and TGF-β1 stimulated TG2 secretion. Knockout of syndecan-4 (SDC4) greatly impaired TG2 exosomal secretion. TG2 coprecipitated with SDC4 from exosome lysate but not ectosome lysate. Ex vivo, EGFP-tagged TG2 accumulated in globular elements (blebs) protruding/retracting from the plasma membrane of primary cortical TECs, and SDC4 knockout impaired bleb formation, affecting TG2 release. Through this combined in vivo and in vitro approach, we have dissected the pathway through which TG2 is secreted from TECs in CKD