ADAHELI+: Exploring the fast, dynamic Sun in the X-ray, optical, and near-infrared

Advanced Astronomy for Heliophysics Plus (ADAHELI+) is a project concept for a small solar and space weather mission with a budget compatible with an European Space Agency (ESA) S-class mission, including launch, and a fast development cycle. ADAHELI+ was submitted to the European Space Agency by a European-wide consortium of solar physics research institutes in response to the “Call for a small mission opportunity for a launch in 2017,” of March 9, 2012. The ADAHELI+ project builds on the heritage of the former ADAHELI mission, which had successfully completed its phase-A study under the Italian Space Agency 2007 Small Mission Programme, thus proving the soundness and feasibility of its innovative low-budget design. ADAHELI+ is a solar space mission with two main instruments: ISODY+: an imager, based on Fabry–Pérot interferometers, whose design is optimized to the acquisition of highest cadence, long-duration, multiline spectropolarimetric images in the visible/near-infrared region of the solar spectrum. XSPO: an x-ray polarimeter for solar flares in x-rays with energies in the 15 to 35 keV range. ADAHELI+ is capable of performing observations that cannot be addressed by other currently planned solar space missions, due to their limited telemetry, or by ground-based facilities, due to the problematic effect of the terrestrial atmospher

Treating bipolar depression with esketamine: Safety and effectiveness data from a naturalistic multicentric study on esketamine in bipolar versus unipolar treatment‐resistant depression

© 2023 The Authors. Bipolar Disorders published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives. https://creativecommons.org/licenses/by-nc-nd/4.0/Background: Bipolar depression accounts for most of the disease duration in type I and type II bipolar disorder (BD), with few treatment options, often poorly tolerated. Many individuals do not respond to first‐line therapeutic options, resulting in treatment‐resistant bipolar depression (B‐TRD). Esketamine, the S‐enantiomer of ketamine, has recently been approved for treatment‐resistant depression (TRD), but no data are available on its use in B‐TRD. Objectives: To compare the efficacy of esketamine in two samples of unipolar and bipolar TRD, providing preliminary indications of its effectiveness in B‐TRD. Secondary outcomes included the evaluation of the safety and tolerability of esketamine in B‐TRD, focusing on the average risk of an affective switch. Methods: Thirty‐five B‐TRD subjects treated with esketamine nasal spray were enrolled and compared with 35 TRD patients. Anamnestic data and psychometric assessments (Montgomery‐Asberg Depression Rating Scale/MADRS, Hamilton‐depression scale/HAM‐D, Hamilton‐anxiety scale/HAM‐A) were collected at baseline (T0), at one month (T1), and three months (T2) follow up. Results: A significant reduction in depressive symptoms was found at T1 and T2 compared to T0, with no significant differences in response or remission rates between subjects with B‐TRD and TRD. Esketamine showed a greater anxiolytic action in subjects with B‐TRD than in those with TRD. Improvement in depressive symptoms was not associated with treatment‐emergent affective switch. Conclusions: Our results supported the effectiveness and tolerability of esketamine in a real‐world population of subjects with B‐TRD. The low risk of manic switch in B‐TRD patients confirmed the safety of this treatment.Peer reviewe