Non-Adaptive Matroid Prophet Inequalities

We consider the problem of matroid prophet inequalities. This problem has been ex- tensively studied in case of adaptive prices, with [KW12] obtaining a tight 2-competitive mechanism for all the matroids. However, the case non-adaptive is far from resolved, although there is a known constant- competitive mechanism for uniform and graphical matroids (see [Cha+20]). We improve on constant-competitive mechanism from [Cha+20] for graphical matroids, present a separate mechanism for cographical matroids, and combine those to obtain constant-competitive mechanism for all regular matroids

RISK FACTORS OF COGNITIVE IMPAIRMENT IN PARKINSON’S DISEASE AND DISCIRCULATORY ENCEPHALOPATHY

The aim of the study was to examine the state of cognitive functions in patients with Parkinson's disease combined with the dyscirculatory encephalopathy and identify their risk factors for cognitive impairment. The results of the study showed that the frequency of cognitive impairment in patients with Parkinson's disease combined with the dyscirculatory encephalopathy was 90.3 %, Parkinson's disease without brain vascular disease - 28.6 %. Patients with concomitant cerebrovascular disease had more severe frontal deficit (mean score on the FAB in the main group -14.86 ± 2.18, in the control -16.93 ± 2.21; p < 0.0001), which manifested itself in the form of difficulty when performing tests for dynamic movements, simple and complicated reactions of choice, had the worst performance of speech and general mental activity, attention. In order to assess the relationship of certain clinical, social and biological factors with indicators of cognitive functions we conducted Spearman rank correlation analysis. Risk factors for the development of cognitive impairment of Parkinson's disease combined with vascular encephalopathy were age of patients, severity of motor impairment, duration and severity of hypertension, coronary heart disease, and the presence of acute cardiovascular events in history

Fixed combinations in modern hypertension treatment algorithms

Modern appropriate treatment of hypertension involves the use of combination antihypertensive therapy. According to updated version of European Society of Cardiology 2018 guidelines, renin-angiotensin-aldosterone system blockers must be used as first-line drugs, including in combination with hydrochlorothiazide. This article presents the algorithms for the management of patients with uncomplicated and asymptomatic (with target lesions) arterial hypertension. It also described the management of patients with concomitant cardiovascular, cerebrovascular, renal pathology and diabetes mellitus, and use of fixed combination of candesartan and hydrochlorothiazide. The article presents research data that confirmed not only the high antihypertensive efficacy of this combination, but also demonstrated its neutral metabolic profile, organ-protective effects, the ability to use in patients with chronic kidney disease, chronic heart failure, prior stroke, as well as high tolerability and treatment adherence

Stroke prevention for non-valvular atrial fibrillation: how to make the right choice of directly acting oral anticoagulants?

Patients with atrial fibrillation have a high risk of developing stroke and death, which requires constant anticoagulant support. In this regard, the physician faces the difficult task of selecting the appropriate oral anticoagulant for patient with individual risk factors and comorbidities. Currently, three non-vitamin K antagonist oral anticoagulants or directly acting oral anticoagulants have been registered in the Russia, which in large randomized clinical trials (RCTs) were compared with warfarin in the prevention of stroke and systemic embolism. The present article analyzes the data of RCTs, postmarketing studies of oral anticoagulants, and presents groups of patients for whom these drugs are preferred. The choice of oral anticoagulants for the prevention of stroke in the following subgroups of patients with atrial fibrillation is discussed: patients with one stroke risk factor (CHA2DS2VASc1 in men or 2 in women), patients of different age groups, patients with concomitant coronary artery disease/acute coronary syndrome, a history of stroke, patients with chronic kidney disease, patients with a high risk of gastrointestinal bleeding, and a group of patients with concomitant arterial hypertension and chronic heart failure. We compared the efficacy and safety of oral non-vitamin K antagonist oral anticoagulants or directly acting oral anticoagulants with vitamin K antagonists in patients with non-valvular atrial fibrillation

Continuing Education as a Teachers’ Professional Culture Component

The relevance of the research problem of modern approaches to forming and development of the teacher’s professional culture in the conditions of informatization and digitalization of the educational environment is caused by the necessity of continuing education and raising its quality.In this connection, the present paper is directed to the study of the potential of modern ICT as a resource of the teachers’ professional development in the process of their continuing education.The leading method in this problem study is the method of generalization of domestic and foreign researches results in the field of continuing education, and analysis of the up-to-date experience, modern pedagogical practices of using innovative technologies making it possible to disclose successfulness of forming the teacher’s informational and communicative culture. Research data and results of questioning 525 pedagogues are expounded supporting the necessity of forming new possible instruments of developing pedagogical culture.The paper deals with some peculiarities of modern approaches to forming and developing the teacher’s professional culture within the frames of supplementary professional education as a component of continuing education. Included are the results of empirical research of an influence of the use by teachers of educational organizations modern informational and communicative technologies aimed at positive interaction in a collective body.Practical significance of the research results, presented in the paper is in the proof of effectiveness of implementing variable module programs aimed at teaching pedagogues the mediation technology and the technology of joint digital model-building electronic aids.As a result of the research, it has been asserted that integration of the informative-communicative component while developing professional culture and orienting educational process to expanding knowledge alongside informational, socio-psychological and upbringing aspects in the teacher’s activity, it is possible to ascertain successfulness of raising the quality of education, a positive motivation for using the competencies acquired and broadening the potentialities of the educational environment

Telmisartan in the hypertension treatment: from pharmacological characteristics to clinical benefits

The current study describes pharmacological features and benefits of using the angiotensin II receptor blocker telmisartan in actual clinical practice. This bifunctional agent has a number of unique pharmacokinetic features: the longest duration of action, high lipophilicity and maximum efficiency in PPARy activation. The results of numerous studies confirmed the high efficacy of telmisartan and the ability to control blood pressure during the day and the early-morning hours compared to other antihypertensive drugs. The main pleutrophic effects of telmisartan have been proven at most stages of the cardiovascular and renal continuum, the main of which are a decrease in insulin resistance, an adiponectin levels increase, an improvement of endothelial function, angioprotective and renoprotective effects, and the regression of left ventricular hypertrophy. The ability of telmisartan to improve prognosis of patients with high cardiovascular risk and to reduce mortality and the number of cardiovascular complications has been proven. Based on the data of large-scale studies, the possibilities of using telmisartan (80 mg/day) were considered, including in combination with hydrochlorothiazide, as the most effective dual fixed-dose combination and one of the main modern antihypertensive strategies

Continuing Education as a Teachers’ Professional Culture Component

The relevance of the research problem of modern approaches to forming and development of the teacher’s professional culture in the conditions of informatization and digitalization of the educational environment is caused by the necessity of continuing education and raising its quality.In this connection, the present paper is directed to the study of the potential of modern ICT as a resource of the teachers’ professional development in the process of their continuing education.The leading method in this problem study is the method of generalization of domestic and foreign researches results in the field of continuing education, and analysis of the up-to-date experience, modern pedagogical practices of using innovative technologies making it possible to disclose successfulness of forming the teacher’s informational and communicative culture. Research data and results of questioning 525 pedagogues are expounded supporting the necessity of forming new possible instruments of developing pedagogical culture.The paper deals with some peculiarities of modern approaches to forming and developing the teacher’s professional culture within the frames of supplementary professional education as a component of continuing education. Included are the results of empirical research of an influence of the use by teachers of educational organizations modern informational and communicative technologies aimed at positive interaction in a collective body.Practical significance of the research results, presented in the paper is in the proof of effectiveness of implementing variable module programs aimed at teaching pedagogues the mediation technology and the technology of joint digital model-building electronic aids.As a result of the research, it has been asserted that integration of the informative-communicative component while developing professional culture and orienting educational process to expanding knowledge alongside informational, socio-psychological and upbringing aspects in the teacher’s activity, it is possible to ascertain successfulness of raising the quality of education, a positive motivation for using the competencies acquired and broadening the potentialities of the educational environment

Statin therapy in patients with high and very high cardiovascular risk: an optimal approach

This article discusses the problems of adequate therapy for dys-lipidemia in patients with high and very high cardiovascular risk in clinical practice. Updated Russian and European guidelines for the treatment of dyslipidemia pick out five categories of cardiovascular risk and clarify goals of prevention and treatment of atherosclerosis. The data of most significant clinical studies on rosuvastatin, highlighting its high lipid-lowering efficacy, the effect on the progression of atherosclerosis and the prognosis in patients with cardiovascular disease, are presented

ANTIAGGREGANT THERAPY AND REDUCTION OF HIGH RESIDUAL PLATELET REACTIVITY

Aim. To assess the levels of residual platelet reactivity (RPR) and its potential correction by antiaggregant therapy in patients with angina. Material and methods. The study included 40 patients with coronary heart disease (CHD), aged under 70 years, with adequate blood pressure control and no contraindications for antiaggregant therapy. All participants underwent general clinical examination, general blood assay, blood biochemistry, and platelet aggregation assessment (blind method). ADP (5 mkmol/l) was used as an aggregation inductor. The patients were randomised into two groups, to compare the antiaggregant activity of aspirin (thrombo ASS 100 mg) vs. plagril (clopidogrel 75 mg), and plavix (75 mg) vs. plagril (75 mg). Platelet aggregation was assessed at baseline and at least three weeks later. After three weeks of the initial therapy, the patients were switched to another therapy arm (cross-over). Finally, all patients were receiving two antiaggregants (thrombo ASS and plagril). Results. During the therapy with enteric coated aspirin (100 mg), RPR above the target level (&gt;46%) was observed in 72,5%. After switching to clopidogrel therapy, target RPR levels were achieved in almost 50% (n=16). Among remaining resistant patients (n=13; 32,5%), 8 achieved target RPR while receiving a combination of aspirin and plagril. Therefore, only 5 patients (12,5%) were resistant to both medications. Clopidogrel monotherapy did not reduce RPR to target levels in 14 patients (35%). In this group, aspirin was effective only in one patient. Conclusion. High RPR levels were more prevalent during the treatment with enteric coated aspirin (72,5%), compared to clopidogrel therapy (plagril or plavix; 35%; p&lt;0,001). Only 12,5% of the participants were resistant to both medications (aspirin and clopidogrel). Overcoming this resistance could be possible with the use of new thienopyridine antiaggregants (prasugrel) or glycoprotein IIb/IIIa inhibitors

QUALITY OF LIFE IN PATIENTS WITH HYPERTENSION, CORONARY HEART DISEASE, AND ATHEROSCLEROTIC LESION OF LOWER EXTREMITY ARTERIES IN THE SECONDARY PREVENTION OF COMPLICATIONS

Atherosclerotic lesion of lower extremity arteries frequently complicates the long-term course of hypertension and it is generally associated with coronary heart disease. Our study has attempted to evaluate the impact of combination antihypertensive therapy involving amlodipine, bisoprolol, and lisinopril on quality of life in this category of patients.</p