1 research outputs found
Ameliorating effects of Raphanus sativus leaves on sodium arsenite-induced perturbation of blood indices in Swiss albino mice
Objective: To evaluate the ameliorating effects of Raphanus sativus leaves (RSL) against sodium arsenite (Sa)-induced adverse effects through mice experiments.
Methods: Swiss albino mice were divided into four equal groups: control, Sa, RSL, RSLÂ +Â Sa. Sa (10Â mg/kg body weight/day), and powder form of RSL (50Â mg/kg body weight/day) were provided as food supplement orallty. Blood indices were measured using commercially available kits through colorimetric methods.
Results: It was observed that lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase activities were significantly (PÂ <Â 0.05) higher in Sa-treated mice than those in the control group. RSL significantly reduced Sa-induced elevation of the activities of these enzymes in serum significantly (PÂ <Â 0.05). Serum butyrylcholinesterase activity and high density lipoproteins cholesterol levels in Sa-treated mice were significantly (PÂ <Â 0.05) lower than the control group, and the food supplementation of RSL could significantly (PÂ <Â 0.05) prevent the reduction of Sa-mediated serum butyryl cholinesterase activity and high density lipoproteins cholesterol levels. RSL could also reduce the Sa-induced elevation of serum urea level significantly (PÂ <Â 0.05).
Conclusions: Results of this study suggest the protective or ameliorating effects of RSL on Sa-induced perturbation of blood indices are related to the hepatic, cardiovascular and kidney dysfunction. Therefore, RSL may be useful to reduce arsenic toxicity in human in the future