HpIMPDH- a potential target for gastric cancer

by Pragati Saxena and Hoime Banerje

Role of kshara (an alkali preparation) in wound healing with special reference to cervical erosion

Cervical erosion is caused by the replacement of the stratified squamous epithelium of the ectocervix with the endocervical columnar epithelium. In Ayurvedic classics, it can be co-related to garbhashayagrivagatavrana. Its management mainly includes destruction of overgrown epithelium by different techniques has its own limitations and side effects. Further observing its prevalence there is a requirement for a treatment modality which is more efficient and cost-effective. Kshara which possesses lekhana (scrapping), vrana-shodhana (wound cleansing), and ropana (wound healing) properties as described in Ayurveda, provides a scientific background of the therapeutic application in the management. Different review works revealed the potential use of kshara on wound healing due to its alkalinity which maintain the body pH within the normal range and thus maintains different cellular and extracellular function. Therefore, kshara is found to be an important preparation that has been investigated for its gynecological uses by different scholars

A Literary Review of Local Application of Palasha kshara (Alkali of Butea monosperma [Lam.] Taub.) in Cervical Erosion: An Ayurvedic Understanding

Objective:(1) To review the studies on Palasha kshara in cervical erosion for better Ayurvedic understanding and (2) Development of a treatment modality that is more efficient and cost-effective at the same time.Data Source:Classical Ayurvedic textbooks Charak Samhita, Sushruta Samhita, Ashtanga Sangraha, Bhavprakash Nighantu, commentaries, modern literature, and research journals available from database PubMed and Google Scholar were searched to interpret the action of Kshara and Palasha.Review Methods:Both Ayurveda classics and recent research on the Palasha kshara and its therapeutic significance in cervical erosion (CE) were explored.Results:It is found that different scholars worked on Palasha kshara and quoted its importance in the management of CE.Conclusion:Understanding the role and action of Palasha kshara is crucial for developing a treatment modality that is efficient and cost-effective simultaneously

To compare the sensory and motor blockade produced by caudal Bupivacaine and Ropivacaine in pediatric patients

Background & Method: The aim of the study is to compare the sensory and motor blockade produced by caudal Bupivacaine and Ropivacaine in pediatric patients. Patients were randomly allocated to 1 of the 2 groups (n = 25) by using a random number table, to receive caudal block with either Inj Bupivacaine (0.25%) 1ml/kg (Group I) or Inj. Ropivacaine (0.25%) 1ml/kg (Group II). Result: The mean age distribution in Group Bupivacaine and Group Ropivacaine were almost the same without any significant difference. Heart rate and systolic arterial pressures measured at specific time intervals showed no significant difference. Conclusion: Present study was designed to compare the effect of bupivacaine versus ropivacaine used in caudal block in pediatric patients, in a prospective randomized controlled study. Mean motor score at different time intervals postoperatively was more for ropivacaine group but Heart rate and systolic arterial pressures measured at specific time intervals were similar

Analysis of 16 Bit Microprocessor Architecture on FPGA Using VHDL

ABSTRACT: This paper involves the design and simulation of 16 bit microprocessor architecture on FPGA using VHDL. Significant features such as the , increased speed ,minimal implementation real-estate, reduction in power and maximum configurability are provided by several FPGAs. Where earlier a design may have included 6 to 10 ASICs, but today the same design can be achieved using only single FPGA.VHDL is used in order to programme FPGA.VHDL is an acronym for very high-speed integrated circuit hardware description language. This model actually represents the textual description of a hardware design or a piece of design which, when simulated mimics the design behavior .The processor contains a number of basic modules. These modules are register array of 8X16 bit register, an ALU, shift register, program counter , an instruction register ,an address register, a comparator and control unit. All of these units or modules are assembled together and communicate through a common 16 bit tristate data bus. KEYWORDS: Register transfer level, Reduced instruction set computer(RISC), Very high speed integrated circuit(VHSIC) hardware description language , Arithmetic logic unit(ALU), Field programmable gate array(FPGA). I. LITEARTURE SURVEY Since the programmable logic technology has been developed highly. It has become feasible that the processors based on FPGA are implemented in the laboratory. Several soft processor cores are being available now days, such as Xilinx, Pico Blaze, Altera Nios. But these processor cores are being provided as black boxes or black box units in which case a user is just unable to monitor internal signals, and the operation process, neither can modify the original structure. FPGAs have especially led to the development of designs in high level description languages like VHDL or Verilog ,which allow the designer to conceive the design at the level of RTL without reference to the final technology or vendor used for the final implementation

To Compare the Sensory and Motor Blockade Produced by Caudal Bupivacaine and Ropivacaine in Pediatric Patients

Background & Method: The aim of the study is to compare the sensory and motor blockade produced by caudal Bupivacaine and Ropivacaine in pediatric patients. Patients were randomly allocated to 1 of the 2 groups (n = 25) by using a random number table, to receive caudal block with either Inj Bupivacaine (0.25%) 1ml/kg (Group I) or Inj. Ropivacaine (0.25%) 1ml/kg (Group II). Result: The mean age distribution in Group Bupivacaine and Group Ropivacaine were almost the same without any significant difference. Heart rate and systolic arterial pressures measured at specific time intervals showed no significant difference. Conclusion: Present study was designed to compare the effect of bupivacaine versus ropivacaine used in caudal block in pediatric patients, in a prospective randomized controlled study. Mean motor score at different time intervals postoperatively was more for ropivacaine group but Heart rate and systolic arterial pressures measured at specific time intervals were similar

Synthesis, Structure–Activity Relationships, and Biological Studies of Chromenochalcones as Potential Antileishmanial Agents

Antileishmanial activities of a library of synthetic chalcone analogues have been examined. Among them, five compounds (<b>11</b>, <b>14</b>, <b>16</b>, <b>17</b>, <b>22</b>, and <b>24</b>) exhibited better activity than the marketed drug miltefosine in in vitro studies against the intracellular amastigotes form of Leishmania donovani. Three promising compounds, <b>16</b>, <b>17</b>, and <b>22</b>, were tested in a L. donovani/hamster model. Oral administration of chalcone <b>16</b>, at a concentration of 100 mg/kg of body weight per day for 5 consecutive days, resulted in >84% parasite inhibition at day 7 post-treatment and it retained the activity until day 28. The molecular and immunological studies revealed that compound <b>16</b> has a dual nature to act as a direct parasite killing agent and as a host immunostimulant. Pharmacokinetics and serum albumin binding studies also suggest that compound <b>16</b> has the potential to be a candidate for the treatment of the nonhealing form of leishmaniasis