Impact des Déchets Plastiques sur les Pâturages Urbains et Péri-urbains de la Ville de Dori, Région du Sahel : cas des Ruminants Domestiques

Les pâturages naturels constituent la principale ressource alimentaire des ruminants dans la zone urbaine et péri-urbaine de Dori. Ces pâturages naturels sont non seulement insuffisants pour les animaux mais aussi pollués par les sachets plastiques. Cette insuffisance alimentaire (quantitative et qualitative) amène les ruminants à ingérer des sachets plastiques. Notre étude avait pour objectif général d’étudier la prévalence de l’ingestion des sachets plastiques chez les ruminants (bovins, caprins et ovins). Elle s’est déroulée de février à juin 2021 par une collecte aléatoire de données à l’abattoir sur 600 échantillons de ruminants domestiques : 200 bovins, 200 caprins et 200 ovins. Nos résultats ont révélé que la prévalence de l’ingestion des sachets n’est pas liée à l’espèce: 31,5% chez les ovins, 30% chez les bovins et 23% chez les caprins (p = 0,131). Cette prévalence n’est pas également liée au sexe: 30% chez les femelles contre 26% chez les mâles (p = 0,379). Par ailleurs, les poids des sachets ingérés variaient significativement d’une espèce à l’autre (p < 0,001). Ainsi les bovins et ovins avaient tendance à en consommer plus que les caprins (p < 0,05). Les poids vifs et carcasses des animaux ayant ingérés des sachets plastiques sont sensiblement égaux à ceux qui n’en ont pas ingérés. Notre étude suggère que des dispositions particulières soient prises, notamment l’élevage en stabulation et la sensibilisation à l’usage et gestion des sachets dans les villes.   Natural pastures are the main alimentary resource for ruminants in the urban and peri-urban area of Dori. These natural pastures are not only insufficient for the animals but also polluted by plastic bags. This food insufficiency (quantitative and qualitative) leads ruminants to ingest plastic bags. The general objective of our study was to investigate the prevalence of plastic bag ingestion in ruminants (cattle, goats and sheep). It was conducted from February to June 2021 through random data collection at the abattoir on 600 samples of domestic ruminants: 200 cattle, 200 goats and 200 sheep. Our results revealed that the prevalence of plastic ingestion is not related to species: 31.5% in sheep, 30% in cattle and 23% in goats (p = 0.131). This prevalence was also not linked to sex: 30% in females versus 26% in males (p = 0.379). Furthermore, the weights of the plastic bags ingested varied significantly between species (p < 0.001). Cattle and sheep tended to consume more than goats (p < 0.05). The live and carcass weights of animals that ingested plastic bags were approximately equal to those that did not. Our study suggests that special measures should be taken, including stall breeding and sensitisation on the use and management of bags in cities

Impact des Déchets Plastiques sur les Pâturages Urbains et Péri-urbains de la Ville de Dori, Région du Sahel : cas des Ruminants Domestiques

Les pâturages naturels constituent la principale ressource alimentaire des ruminants dans la zone urbaine et péri-urbaine de Dori. Ces pâturages naturels sont non seulement insuffisants pour les animaux mais aussi pollués par les sachets plastiques. Cette insuffisance alimentaire (quantitative et qualitative) amène les ruminants à ingérer des sachets plastiques. Notre étude avait pour objectif général d’étudier la prévalence de l’ingestion des sachets plastiques chez les ruminants (bovins, caprins et ovins). Elle s’est déroulée de février à juin 2021 par une collecte aléatoire de données à l’abattoir sur 600 échantillons de ruminants domestiques : 200 bovins, 200 caprins et 200 ovins. Nos résultats ont révélé que la prévalence de l’ingestion des sachets n’est pas liée à l’espèce: 31,5% chez les ovins, 30% chez les bovins et 23% chez les caprins (p = 0,131). Cette prévalence n’est pas également liée au sexe: 30% chez les femelles contre 26% chez les mâles (p = 0,379). Par ailleurs, les poids des sachets ingérés variaient significativement d’une espèce à l’autre (p < 0,001). Ainsi les bovins et ovins avaient tendance à en consommer plus que les caprins (p < 0,05). Les poids vifs et carcasses des animaux ayant ingérés des sachets plastiques sont sensiblement égaux à ceux qui n’en ont pas ingérés. Notre étude suggère que des dispositions particulières soient prises, notamment l’élevage en stabulation et la sensibilisation à l’usage et gestion des sachets dans les villes.   Natural pastures are the main alimentary resource for ruminants in the urban and peri-urban area of Dori. These natural pastures are not only insufficient for the animals but also polluted by plastic bags. This food insufficiency (quantitative and qualitative) leads ruminants to ingest plastic bags. The general objective of our study was to investigate the prevalence of plastic bag ingestion in ruminants (cattle, goats and sheep). It was conducted from February to June 2021 through random data collection at the abattoir on 600 samples of domestic ruminants: 200 cattle, 200 goats and 200 sheep. Our results revealed that the prevalence of plastic ingestion is not related to species: 31.5% in sheep, 30% in cattle and 23% in goats (p = 0.131). This prevalence was also not linked to sex: 30% in females versus 26% in males (p = 0.379). Furthermore, the weights of the plastic bags ingested varied significantly between species (p < 0.001). Cattle and sheep tended to consume more than goats (p < 0.05). The live and carcass weights of animals that ingested plastic bags were approximately equal to those that did not. Our study suggests that special measures should be taken, including stall breeding and sensitisation on the use and management of bags in cities

Pregnancy rate and birth outcomes among women receiving antiretroviral therapy in Burkina Faso: a retrospective cohort study

Introduction: In Sub-Saharan Africa, few studies reported pregnancy incidence and outcomes in women taking antiretroviral therapy (ART). This survey aims to estimate the incidence and outcomes of pregnancy in a cohort of HIV positive women initiating ART in Bobo-Dioulasso, Burkina Faso. Methods: We carried out a retrospective cohort study. We selected women in childbearing age initiating ART and followed up in Bobo-Dioulasso teaching hospital between January 2005 and June 2011. The incidence of pregnancies during follow-up was calculated. Childbirth was defined by the expulsion of a fetus after 22 weeks of amenorrhea. Before this term, it is an abortion. Childbirth is said premature if it occurs before 37 weeks of gestation, to term if it occurs between the 38th and the 42nd week. The annual age-standardized fertility rates were calculated using the baseline population from the 2010 demographic and health survey (DHS) in Burkina Faso. Results: A total of 1,763 women of childbearing age under ART were included in the study. They ranged between 18 and 48 years old with a median of 35 years old. A total of 222 pregnancies were observed during 4639 women-years of follow-up, corresponding to an incidence density of 5 pregnancies for 100 women-years (95% CI: 4.2-5.5). Among the 222 pregnancies recorded, 9(4.0%) ended with abortion, 205(92.4%) with childbirth (including 15 premature childbirths); the outcome of 8(3.6 %) pregnancies were unknown abortion. Live birth and stillborn rates were 94.0% (193/205) and 6.0% respectively. The standard fertility rate in our cohort was 45 live births for 1,000 women-years. The general decrease in fertility rates was 66.0% among women infected with HIV compared to the overall population Conclusion: This study shows a low pregnancy incidence among women initiating ART as compared to their peers from the general population. Pregnancies that occurred during ART generally end with live births. Care packages for HIV infected women of childbearing age must include reproductive health services to better address this issue.Pan African Medical Journal 2016; 2

Impact des Déchets Plastiques dans l’Alimentation des Ruminants Domestiques: cas de l’Élevage Urbain et Périurbain de la Ville de Dori, Région du Sahel

Les pâturages naturels constituent la principale ressource alimentaire des ruminants dans la zone urbaine et péri-urbaine de Dori. Ces pâturages naturels sont non seulement insuffisants pour les animaux mais aussi pollués par les sachets plastiques. Cette insuffisance alimentaire quantitative et qualitative amène les ruminants à ingérer des sachets plastiques. La presente étude avait pour objectif général d’étudier la prévalence de l’ingestion des sachets plastiques chez les ruminants, notamment des bovins, caprins et ovins. Elle s’est déroulée de février à juin 2021 par une collecte aléatoire de données à l’abattoir de Dori lors d’une étude tranversale sur un échantillon de 600 ruminants domestiques : 200 bovins, 200 caprins et 200 ovins. Les résultats ont révélé que la prévalence de l’ingestion des sachets n’est pas liée à l’espèce: 31,5% chez les ovins, 30% chez les bovins et 23% chez les caprins (p = 0,131). Cette prévalence n’est pas également liée au sexe: 30% chez les femelles contre 26% chez les mâles (p = 0,379). Par ailleurs, les poids des sachets ingérés variaient significativement d’une espèce à l’autre (p < 0,001). Ainsi les bovins et ovins avaient tendance à en consommer plus que les caprins (p < 0,05). Les animaux qui ingéraient une quantité de sachets inférieure à 100 g étaient plus nombeux que ceux en consommaient plus (p < 0,001). Ainsi, l’ingestion n’a pas eu d’effet sur les poids vifs et carcasses des animaux ayant ingérés des sachets plastiques. L’étude suggère que des dispositions particulières soient prises, notamment l’élevage en stabulation et la sensibilisation à l’usage et à une meilleure gestion des sachets plastiques dans la commune de Dori.   Natural pastures are the main alimentary resource for ruminants in the urban and peri-urban area of Dori. These natural pastures are not only insufficient for the animals but also polluted by plastic bags. This quantitative and qualitative food insufficiency leads ruminants to ingest plastic bags. The general objective of this study was to investigate the prevalence of plastic bag ingestion in ruminants, including cattle, goats and sheep. It was conducted from February to June 2021 through random data collection at the Dori abattoir during a cross-sectional study on a sample of 600 domestic ruminants: 200 cattle, 200 goats and 200 sheep. The results revealed that the prevalence of plastic ingestion is not related to species: 31.5% in sheep, 30% in cattle and 23% in goats (p = 0.131). This prevalence was also not linked to sex: 30% in females versus 26% in males (p = 0.379). Furthermore, the weights of the plastic bags ingested varied significantly between species (p < 0.001). Cattle and sheep tended to consume more than goats (p < 0.05). Animals that consumed less than 100 g of plastic wastes were more numerous than those that consumed more (p < 0.001). Thus, ingestion had no effect on the live and carcass weights of animals that ingested plastic bags. The study suggests that special measures should be taken, including stall breeding and sensitisation on the use and better management of bags in the Dori commune

Immunologic response in treatment-naïve HIV-2-infected patients:the IeDEA West Africa cohort

Introduction: Response to antiretroviral therapy (ART) among individuals infected with HIV-2 is poorly described. We compared the immunological response among patients treated with three nucleoside reverse-transcriptase inhibitors (NRTIs) to boosted protease inhibitor (PI) and unboosted PI-based regimens in West Africa. Methods: This prospective cohort study enrolled treatment-naïve HIV-2-infected patients within the International Epidemiological Databases to Evaluate AIDS collaboration in West Africa. We used mixed models to compare the CD4 count response to treatment over 12 months between regimens. Results: Of 422 HIV-2-infected patients, 285 (67.5%) were treated with a boosted PI-based regimen, 104 (24.6%) with an unboosted PI-based regimen and 33 (7.8%) with three NRTIs. Treatment groups were comparable with regard to gender (54.5% female) and median age at ART initiation (45.3 years; interquartile range 38.3 to 51.8). Treatment groups differed by clinical stage (21.2%, 16.8% and 17.3% at CDC Stage C or World Health Organization Stage IV for the triple NRTI, boosted PI and unboosted PI groups, respectively, p=0.02), median length of follow-up (12.9, 17.7 and 44.0 months for the triple NRTI, the boosted PI and the unboosted PI groups, respectively, p<0.001) and baseline median CD4 count (192, 173 and 129 cells/µl in the triple NRTI, the boosted PI and the unboosted PI-based regimen groups, respectively, p=0.003). CD4 count recovery at 12 months was higher for patients treated with boosted PI-based regimens than those treated with three NRTIs or with unboosted PI-based regimens (191 cells/µl, 95% CI 142 to 241; 110 cells/µl, 95% CI 29 to 192; 133 cells/µl, 95% CI 80 to 186, respectively, p=0.004). Conclusions: In this observational study using African data, boosted PI-containing regimens had better immunological response compared to triple NRTI combinations and unboosted PI-based regimens at 12 months. A randomized clinical trial is still required to determine the best initial regimen for treating HIV-2 infected patients

Decreasing incidence of cryptococcal meningitis in West Africa in the era of highly active antiretroviral therapy.

International audienceCryptococcosis remains a major opportunistic infection in AIDS in sub-Saharan Africa, but few data exist from its western part. We report data from Bobo Dioulasso University Hospital, Bobo-Dioulasso, Burkina Faso, with a steady decline from 14 to two cases per year from 2002 to 2010 which contrasts with the increase (from 147 to 3940) of patients on antiretroviral therapy (ART). Better ART availability decreases the incidence of cryptococcosis in Burkina Faso

Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus.

BACKGROUND: Epidemiologic data suggest that infection with herpes simplex virus type 2 (HSV-2) is associated with increased genital shedding of human immunodeficiency virus type 1 (HIV-1) RNA and HIV-1 transmissibility. METHODS: We conducted a randomized, double-blind, placebo-controlled trial of HSV suppressive therapy with valacyclovir (at a dose of 500 mg twice daily) in Burkina Faso among women who were seropositive for HIV-1 and HSV-2; all were ineligible for highly active antiretroviral therapy. The patients were followed for 24 weeks (12 weeks before and 12 weeks after randomization). Regression models were used to assess the effect of valacyclovir on the presence and quantity of genital and plasma HIV-1 RNA and genital HSV-2 DNA during treatment, adjusting for baseline values, and to evaluate the effect over time. RESULTS: A total of 140 women were randomly assigned to treatment groups; 136 were included in the analyses. At enrollment, the median CD4 cell count was 446 cells per cubic millimeter, and the mean plasma viral load was 4.44 log10 copies per milliliter. With the use of summary-measures analysis, valacyclovir therapy was found to be associated with a significant decrease in the frequency of genital HIV-1 RNA (odds ratio, 0.41; 95% confidence interval [CI], 0.21 to 0.80) and in the mean quantity of the virus (log(10) copies per milliliter, -0.29; 95% CI, -0.44 to -0.15). However, there was no significant decrease in detection of HIV (risk ratio, 0.93; 95% CI, 0.81 to 1.07). HSV suppressive therapy also reduced the mean plasma HIV-1 RNA level by 0.53 log(10) copy per milliliter (95% CI, -0.72 to -0.35). Repeated-measures analysis showed that these effects became significantly stronger during the 3 months of follow-up. CONCLUSIONS: HSV suppressive therapy significantly reduces genital and plasma HIV-1 RNA levels in dually infected women. This finding may have important implications for HIV control. (ClinicalTrials.gov number, NCT00158509 [ClinicalTrials.gov].)

The Day-Hospital of the University Hospital, Bobo Dioulasso: An Example of Optimized HIV Management in Southern Burkina Faso

International audienceObjectivesTo evaluate the epidemiological evolution of patients with HIV (PtHIV), between 2002 and 2012, in a day-hospital that became an HIV reference centre for south-west Burkina Faso.Materials and MethodsThis was a retrospective study of PtHIV followed in the Bobo Dioulasso university hospital since 2002. The study was based on clinical data recorded using ESOPE software and analysed using Excel and SAS.ResultsA total of 7320 patients have been treated at the centre since 2002; the active file of patients increased from 147 in 2002 to 3684 patients in 2012. Mean age was stable at 38.4 years and the majority were female (71%). The delay to initiation of antiretroviral (ARV) treatment after HIV diagnosis decreased from 12.9 months in 2002 to 7.2 months in 2012. The percentage of PtHIV lost to follow-up, untreated for HIV and deaths all decreased after 2005. Voluntary anonymous screening and/or an evocative clinical picture were the main reasons for HIV diagnosis, usually at a late stage (41.1% at WHO stage 3). Virological success increased due to a decrease in time to initiation of ARV treatment and an increase in percentage of patients treated (90.5% in 2012, mainly with 1st line drugs). However, there was also a slight increase in the rate of therapeutic failures and the percentage of patients who progressed to 2nd or 3rd line-ARVs.ConclusionOur day-hospital is a good example of the implementation of a specialist centre for the management of PtHIV in a resource-limited country (Burkina Faso)

Chronic kidney disease and HIV in the era of antiretroviral treatment : findings from a 10-year cohort study in a west African setting

International audienceBACKGROUND:It has been reported that people living with HIV in West Africa exhibited the highest risks for chronic kidney disease (CKD) in the world. Here, we aimed at determining the CKD frequency and changes in kidney function during antiretroviral treatment (ART) in a large cohort of HIV-patients followed in Burkina Faso.METHODS:We included ART-naive adults who initiated ART at the Day Care Unit of the Souro Sanou University Hospital between 01/01/2007 and 12/31/2016. We assessed the estimated glomerular filtration rate (eGFR) by serum creatinine using the Modification of Diet in Renal Disease (MDRD) equation. Following the K/DOQI recommendations, CKD was defined as eGFR < 60 ml/min/1.73m2 at two consecutive measurements at least 3 months apart. The factors associated with eGFR decline or CKD were identified by mixed linear regression and Cox regression, respectively.RESULTS:Three thousand, one hundred and thirty-eight patients (72% women) were followed for a median (IQR) of 4.5(2.2-6.9) years. At baseline, median eGFR (IQR) was 110.7(94.4-128.4) ml/min/1.73m2 and 93 (3%) patients exhibited eGFR < 60 ml/min/1.73m2. The lowest-performing progressions of eGFR during the first year of ART were observed in patients with 40-49 yr. age range (- 8.3[- 11.7;-5.0] ml/min/1.73m2, p < 0.001), age ≥ 50 yr. (- 6.2[- 10.7;-1.8] ml/min/1.73m2, p = 0.006) and high blood pressure (HBP) (- 28.4[- 46.9;-9.9] ml/min/1.73m2, p = 0.003) at ART initiation. Regarding the ART exposure in patients with normal baseline eGFR, zidovudine (AZT) with protease inhibitor (PI) (- 4.7[- 7.7;-1.6] ml/min/1.73m2, p = 0.002), tenofovir (TDF) + PI (- 13.1[- 17.4;-8.7] ml/min/1.73m2, p < 0.001), TDF without PI (- 3.2[- 5.0;-1.4] ml/min/1.73m2, p < 0.001), stavudine (d4T) + PI (- 8.5[- 14.6-2.4] ml/min/1.73m2, p = 0.006) and d4T without PI (- 5.0[- 7.6-2.4] ml/min/1.73m2, p < 0.001) were associated with poorer eGFR progression. The prevalence of CKD was 0.5% and the incidence was 1.9 [1.3; 2.7] cases/1000 person-years. The risk of CKD was higher in patients with HBP (4.3[1.8;9.9], p = 0.001), 40-49 yr. patients (4.2[1.6;11.2], p = 0.004), ≥50 yr. patients (4.5[1.5;14.1], p = 0.009) and patients exposed to abacavir (ABC) or didanosine (ddI) based ART (13.1[4.0;42.9], p < 0.001).CONCLUSIONS:Our findings do not confirm the high risk of CKD reported in previous studies of West Africans with HIV, but support the recommendations for early initiation of ART and close kidney function monitoring in patients with HBP or aged ≥40 yr